NABEC: North American Brain Expression Consortium

This study utilized neurologically normal control samples deposited in North American Brain Expression Consortium (NABEC). This top-level study, phs001300, makes available all phenotype data of the NABEC study participants.
In addition, molecular data of six sub-studies are available through dbGaP:

1. NABEC Genome-Wide Genotyping - phs000249
2. NABEC Exome Sequencing - phs001301
3. NABEC CAGE Sequencing of Human Cerebral Frontal Cortex - phs001302
4. NABEC mRNA Sequencing of human Cerebral Frontal Cortex - phs001353
5. NABEC Total RNA Sequencing of human Cerebral Frontal Cortex - phs001354
6. NABEC Neurochip Genotyping - phs001462
7. NABEC Whole-Genome Sequencing - phs002636

• Study Design:
  • Control Set
• Study Type:
  • Control Set
• Total number of consented subjects: 432
• Subject Sample Telemetry Report (SSTR)

Neurologically normal control individuals only.

• Primary Phenotype: Gene Expression Profiling

• Principal Investigators
  • J. Raphael Gibbs. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA and Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, London, UK.
  • Marcel P. van der Brug. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA and Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, Jupiter, FL, USA.
  • Dena G. Hernandez. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA and Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, London, UK.
  • Bryan J. Traynor. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Michael A. Nalls. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Shiao-Lin Lai. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA and Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, London, UK.
  • Sampath Arepalli. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Allissa Dillman. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Ian P. Rafferty. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Juan Troncoso. Division of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  • Robert Johnson. NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, MD, USA.
  • H. Ronald Zielke. NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, MD, USA.
  • Luigi Ferrucci. Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA.
  • Dan L. Longo. Lymphocyte Cell Biology Unit, Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
  • Mark R. Cookson. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Andrew B. Singleton. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
• Institutes
  • National Institute on Aging, Bethesda, MD, USA.
  • Institute of Neurology, University College London, London, UK.
  • The Scripps Research Institute, Jupiter, FL, USA.
  • Johns Hopkins University, Baltimore, MD, USA.
  • University of Maryland Medical School, Baltimore, MD, USA.
• Funding Sources
  • Z01 AG000949-02. National Institutes of Health, Bethesda, MD, USA.
  • Z01 AG000015-49. National Institutes of Health, Bethesda, MD, USA.