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Childhood Malignant Central Nervous System Neoplasm

MedGen UID:
233149
•Concept ID:
C1334573
•
Neoplastic Process
Synonyms: Childhood Malignant Central Nervous System Neoplasms; Childhood Malignant Central Nervous System Tumors; Malignant Central Nervous System Neoplasms of Childhood; Malignant Central Nervous System Tumors of Childhood; Malignant Childhood Central Nervous System Neoplasms; Malignant Childhood Central Nervous System Tumor; Malignant Childhood Central Nervous System Tumors; Malignant Childhood CNS Neoplasm; Malignant Childhood CNS Tumor; Malignant Childhood Neoplasm of Central Nervous System; Malignant Childhood Neoplasm of CNS; Malignant Childhood Neoplasm of the Central Nervous System; Malignant Childhood Neoplasm of the CNS; Malignant Childhood Tumor of Central Nervous System; Malignant Childhood Tumor of CNS; Malignant Childhood Tumor of the Central Nervous System; Malignant Childhood Tumor of the CNS; Malignant Pediatric Central Nervous System Neoplasm; Malignant Pediatric Central Nervous System Tumor; Malignant Pediatric CNS Neoplasm; Malignant Pediatric CNS Tumor; Malignant Pediatric Neoplasm of Central Nervous System; Malignant Pediatric Neoplasm of CNS; Malignant Pediatric Neoplasm of the Central Nervous System; Malignant Pediatric Neoplasm of the CNS; Malignant Pediatric Tumor of Central Nervous System; Malignant Pediatric Tumor of CNS; Malignant Pediatric Tumor of the Central Nervous System; Malignant Pediatric Tumor of the CNS

Definition

A primary or metastatic malignant neoplasm that affects the central nervous system and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Malignant Central Nervous System Neoplasm

Professional guidelines

PubMed

National UK guidelines for the management of paediatric craniopharyngioma.
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Recent clinical studies

Etiology

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Epidemiology of Brain and Other CNS Tumors.
Ostrom QT, Francis SS, Barnholtz-Sloan JS
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):68. doi: 10.1007/s11910-021-01152-9. PMID: 34817716Free PMC Article
Brain and other central nervous system tumor statistics, 2021.
Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, Fuchs HE, Waite KA, Jemal A, Siegel RL, Barnholtz-Sloan JS
CA Cancer J Clin 2021 Sep;71(5):381-406. Epub 2021 Aug 24 doi: 10.3322/caac.21693. PMID: 34427324
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Radiation-induced meningioma.
Umansky F, Shoshan Y, Rosenthal G, Fraifeld S, Spektor S
Neurosurg Focus 2008;24(5):E7. doi: 10.3171/FOC/2008/24/5/E7. PMID: 18447746

Diagnosis

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Brain and other central nervous system tumor statistics, 2021.
Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, Fuchs HE, Waite KA, Jemal A, Siegel RL, Barnholtz-Sloan JS
CA Cancer J Clin 2021 Sep;71(5):381-406. Epub 2021 Aug 24 doi: 10.3322/caac.21693. PMID: 34427324
Pediatric Neuro-Oncology.
Malbari F
Neurol Clin 2021 Aug;39(3):829-845. Epub 2021 Jun 10 doi: 10.1016/j.ncl.2021.04.005. PMID: 34215389
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW
Neuro Oncol 2021 Aug 2;23(8):1231-1251. doi: 10.1093/neuonc/noab106. PMID: 34185076Free PMC Article
Pediatric Brain Tumors.
Udaka YT, Packer RJ
Neurol Clin 2018 Aug;36(3):533-556. doi: 10.1016/j.ncl.2018.04.009. PMID: 30072070

Therapy

Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety.
Vitanza NA, Wilson AL, Huang W, Seidel K, Brown C, Gustafson JA, Yokoyama JK, Johnson AJ, Baxter BA, Koning RW, Reid AN, Meechan M, Biery MC, Myers C, Rawlings-Rhea SD, Albert CM, Browd SR, Hauptman JS, Lee A, Ojemann JG, Berens ME, Dun MD, Foster JB, Crotty EE, Leary SES, Cole BL, Perez FA, Wright JN, Orentas RJ, Chour T, Newell EW, Whiteaker JR, Zhao L, Paulovich AG, Pinto N, Gust J, Gardner RA, Jensen MC, Park JR
Cancer Discov 2023 Jan 9;13(1):114-131. doi: 10.1158/2159-8290.CD-22-0750. PMID: 36259971Free PMC Article
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Craniopharyngioma.
Müller HL
Endocr Rev 2014 Jun;35(3):513-43. Epub 2014 Jan 27 doi: 10.1210/er.2013-1115. PMID: 24467716
Radiation-induced meningioma.
Umansky F, Shoshan Y, Rosenthal G, Fraifeld S, Spektor S
Neurosurg Focus 2008;24(5):E7. doi: 10.3171/FOC/2008/24/5/E7. PMID: 18447746

Prognosis

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Epidemiology of Brain and Other CNS Tumors.
Ostrom QT, Francis SS, Barnholtz-Sloan JS
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):68. doi: 10.1007/s11910-021-01152-9. PMID: 34817716Free PMC Article
EANO-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours.
Le Rhun E, Guckenberger M, Smits M, Dummer R, Bachelot T, Sahm F, Galldiks N, de Azambuja E, Berghoff AS, Metellus P, Peters S, Hong YK, Winkler F, Schadendorf D, van den Bent M, Seoane J, Stahel R, Minniti G, Wesseling P, Weller M, Preusser M; EANO Executive Board and ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Nov;32(11):1332-1347. Epub 2021 Aug 6 doi: 10.1016/j.annonc.2021.07.016. PMID: 34364998
Pediatric Neuro-Oncology.
Malbari F
Neurol Clin 2021 Aug;39(3):829-845. Epub 2021 Jun 10 doi: 10.1016/j.ncl.2021.04.005. PMID: 34215389
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Clinical prediction guides

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Diagnostic criteria for constitutional mismatch repair deficiency syndrome: suggestions of the European consortium 'care for CMMRD' (C4CMMRD).
Wimmer K, Kratz CP, Vasen HF, Caron O, Colas C, Entz-Werle N, Gerdes AM, Goldberg Y, Ilencikova D, Muleris M, Duval A, Lavoine N, Ruiz-Ponte C, Slavc I, Burkhardt B, Brugieres L; EU-Consortium Care for CMMRD (C4CMMRD)
J Med Genet 2014 Jun;51(6):355-65. Epub 2014 Apr 15 doi: 10.1136/jmedgenet-2014-102284. PMID: 24737826
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Recent systematic reviews

Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.
Onyije FM, Dolatkhah R, Olsson A, Bouaoun L, Deltour I, Erdmann F, Bonaventure A, Scheurer ME, Clavel J, Schüz J
Cancer Epidemiol 2024 Feb;88:102510. Epub 2023 Dec 5 doi: 10.1016/j.canep.2023.102510. PMID: 38056243Free PMC Article
Delay in the diagnosis of paediatric brain tumours: a systematic review.
Kehoe K, Sivaguru H, Coulter I, Cowie C
Childs Nerv Syst 2023 Aug;39(8):2053-2063. Epub 2023 Jun 19 doi: 10.1007/s00381-023-06022-y. PMID: 37336792
Giant prolactinoma in children and adolescents: a single-center experience and systematic review.
Kumar S, Sarathi V, Lila AR, Sehemby M, Memon SS, Karlekar M, Sankhe S, Patil VA, Shah N, Bandgar T
Pituitary 2022 Dec;25(6):819-830. Epub 2022 Jul 18 doi: 10.1007/s11102-022-01250-y. PMID: 35851929
Anthropometrics at birth and risk of a primary central nervous system tumour: A systematic review and meta-analysis.
Georgakis MK, Kalogirou EI, Liaskas A, Karalexi MA, Papathoma P, Ladopoulou K, Kantzanou M, Tsivgoulis G; NARECHEM-BT Working Group, Petridou ET
Eur J Cancer 2017 Apr;75:117-131. Epub 2017 Feb 20 doi: 10.1016/j.ejca.2016.12.033. PMID: 28219020
Neuropsychiatric presentations and outcomes in children and adolescents with primary brain tumours: Systematic review.
Zyrianova Y, Alexander L, Faruqui R
Brain Inj 2016;30(1):1-9. Epub 2015 Nov 5 doi: 10.3109/02699052.2015.1075590. PMID: 26536821

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