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Liver and intrahepatic bile duct neoplasm

MedGen UID:
232599
•Concept ID:
C1333976
•
Neoplastic Process
Synonyms: epithelial hepatic and intrahepatic bile duct neoplasm; Hepatic and Intrahepatic Bile Duct Neoplasm; hepatic and intrahepatic bile duct neoplasm; liver and intrahepatic bile duct epithelial neoplasm; Liver and Intrahepatic Bile Duct Neoplasm; liver and intrahepatic bile duct neoplasm; Liver Neoplasm; liver neoplasm; liver neoplasm (disease); liver tumor; liver tumour; neoplasm of liver; tumor of liver; tumour of liver
 
Monarch Initiative: MONDO:0024477

Definition

A benign or malignant neoplasm that affects the liver parenchyma or intrahepatic bile ducts. Representative examples of benign neoplasms include hepatocellular adenoma, and bile duct adenoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver and intrahepatic bile duct neoplasm

Professional guidelines

PubMed

Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and future therapeutic landscape for clinicians.
Moris D, Palta M, Kim C, Allen PJ, Morse MA, Lidsky ME
CA Cancer J Clin 2023 Mar;73(2):198-222. Epub 2022 Oct 19 doi: 10.3322/caac.21759. PMID: 36260350
Clinical treatment of cholangiocarcinoma: an updated comprehensive review.
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

Pathology of Cholangiocarcinomas.
Guedj N
Curr Oncol 2022 Dec 26;30(1):370-380. doi: 10.3390/curroncol30010030. PMID: 36661679Free PMC Article
Clinical treatment of cholangiocarcinoma: an updated comprehensive review.
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Cholangiocellular Carcinoma.
Vogel A, Saborowski A
Digestion 2017;95(3):181-185. Epub 2017 Mar 14 doi: 10.1159/000454763. PMID: 28288474
Transplantation for cholangiocarcinoma.
Masuoka HC, Rosen CB
Clin Liver Dis 2011 Nov;15(4):699-715. doi: 10.1016/j.cld.2011.08.004. PMID: 22032524
Pathophysiology of cholangiopathies.
Strazzabosco M, Fabris L, Spirli C
J Clin Gastroenterol 2005 Apr;39(4 Suppl 2):S90-S102. doi: 10.1097/01.mcg.0000155549.29643.ad. PMID: 15758666

Diagnosis

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.
Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587Free PMC Article
Pathology of Cholangiocarcinomas.
Guedj N
Curr Oncol 2022 Dec 26;30(1):370-380. doi: 10.3390/curroncol30010030. PMID: 36661679Free PMC Article
How I treat biliary tract cancer.
Lamarca A, Edeline J, Goyal L
ESMO Open 2022 Feb;7(1):100378. Epub 2022 Jan 13 doi: 10.1016/j.esmoop.2021.100378. PMID: 35032765Free PMC Article
Intrahepatic cholangiocarcinoma.
Brown KM, Parmar AD, Geller DA
Surg Oncol Clin N Am 2014 Apr;23(2):231-46. doi: 10.1016/j.soc.2013.10.004. PMID: 24560108Free PMC Article
TRANSHEPATIC CHOLANGIOGRAPHY.
BIRCH JR, SHEA J, CURRIE DJ
Can Med Assoc J 1964 Jun 27;90(26):1442-9. PMID: 14158553Free PMC Article

Therapy

Integrating cytotoxic, targeted and immune therapies for cholangiocarcinoma.
Merters J, Lamarca A
J Hepatol 2023 Mar;78(3):652-657. Epub 2022 Nov 15 doi: 10.1016/j.jhep.2022.11.005. PMID: 36400328
Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and future therapeutic landscape for clinicians.
Moris D, Palta M, Kim C, Allen PJ, Morse MA, Lidsky ME
CA Cancer J Clin 2023 Mar;73(2):198-222. Epub 2022 Oct 19 doi: 10.3322/caac.21759. PMID: 36260350
Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing-Assisted Multiomics Analysis.
Bao X, Li Q, Chen J, Chen D, Ye C, Dai X, Wang Y, Li X, Rong X, Cheng F, Jiang M, Zhu Z, Ding Y, Sun R, Liu C, Huang L, Jin Y, Li B, Lu J, Wu W, Guo Y, Fu W, Langley SR, Tano V, Fang W, Guo T, Sheng J, Zhao P, Ruan J
Cancer Immunol Res 2022 Jul 1;10(7):811-828. doi: 10.1158/2326-6066.CIR-21-1101. PMID: 35604302
The Landmark Series: Hilar Cholangiocarcinoma.
Soares KC, Jarnagin WR
Ann Surg Oncol 2021 Aug;28(8):4158-4170. Epub 2021 Apr 7 doi: 10.1245/s10434-021-09871-6. PMID: 33829358Free PMC Article
Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer.
Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, Kleiner DE, Hewitt SM, Ylaya K, Wood BJ, Greten TF, Wang XW
Cancer Cell 2019 Oct 14;36(4):418-430.e6. Epub 2019 Oct 3 doi: 10.1016/j.ccell.2019.08.007. PMID: 31588021Free PMC Article

Prognosis

Cholangiocarcinoma: Epidemiology and risk factors.
Khan SA, Tavolari S, Brandi G
Liver Int 2019 May;39 Suppl 1:19-31. Epub 2019 Mar 24 doi: 10.1111/liv.14095. PMID: 30851228
Cholangiocellular Carcinoma.
Vogel A, Saborowski A
Digestion 2017;95(3):181-185. Epub 2017 Mar 14 doi: 10.1159/000454763. PMID: 28288474
Epidemiology of cholangiocarcinoma.
Bergquist A, von Seth E
Best Pract Res Clin Gastroenterol 2015 Apr;29(2):221-32. Epub 2015 Feb 16 doi: 10.1016/j.bpg.2015.02.003. PMID: 25966423
Transplantation for cholangiocarcinoma.
Masuoka HC, Rosen CB
Clin Liver Dis 2011 Nov;15(4):699-715. doi: 10.1016/j.cld.2011.08.004. PMID: 22032524
Intrahepatic cholangiocarcinoma.
Poultsides GA, Zhu AX, Choti MA, Pawlik TM
Surg Clin North Am 2010 Aug;90(4):817-37. doi: 10.1016/j.suc.2010.04.011. PMID: 20637950

Clinical prediction guides

Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy.
O'Rourke CJ, Salati M, Rae C, Carpino G, Leslie H, Pea A, Prete MG, Bonetti LR, Amato F, Montal R, Upstill-Goddard R, Nixon C, Sanchon-Sanchez P, Kunderfranco P, Sia D, Gaudio E, Overi D, Cascinu S, Hogdall D, Pugh S, Domingo E, Primrose JN, Bridgewater J, Spallanzani A, Gelsomino F, Llovet JM, Calvisi DF, Boulter L, Caputo F, Lleo A, Jamieson NB, Luppi G, Dominici M, Andersen JB, Braconi C
Gut 2024 Feb 23;73(3):496-508. doi: 10.1136/gutjnl-2023-330748. PMID: 37758326Free PMC Article
High endothelial venule is a prognostic immune-related biomarker in patients with resected intrahepatic cholangiocarcinoma.
Zhou Y, Gu Q, Zhu L, Zhang S, Wu H, Pu X, Jiang C, Chen J
Cell Prolif 2023 Dec;56(12):e13513. Epub 2023 Jul 3 doi: 10.1111/cpr.13513. PMID: 37401015Free PMC Article
Tertiary lymphoid structures predict the prognosis and immunotherapy response of cholangiocarcinoma.
Shang T, Jiang T, Lu T, Wang H, Cui X, Pan Y, Xu M, Pei M, Ding Z, Feng X, Lin Y, Li X, Tan Y, Feng F, Dong H, Wang H, Dong L
Front Immunol 2023;14:1166497. Epub 2023 May 10 doi: 10.3389/fimmu.2023.1166497. PMID: 37234171Free PMC Article
Development and validation of a new prognostic immune-inflammatory-nutritional score for predicting outcomes after curative resection for intrahepatic cholangiocarcinoma: A multicenter study.
Zhu J, Wang D, Liu C, Huang R, Gao F, Feng X, Lan T, Li H, Wu H
Front Immunol 2023;14:1165510. Epub 2023 Mar 31 doi: 10.3389/fimmu.2023.1165510. PMID: 37063918Free PMC Article
IgG4-related autoimmune liver disease.
Capurso G, Pedica F, Palumbo D, Della-Torre E
Minerva Gastroenterol (Torino) 2023 Mar;69(1):23-49. Epub 2020 Dec 3 doi: 10.23736/S2724-5895.20.02794-4. PMID: 33267565

Recent systematic reviews

Circular RNA in cholangiocarcinoma: A systematic review and bibliometric analysis.
Zhou Z, Chen C, Han B, Wang Y, Liu Y, Liu Q, Xu X, Yin Y, Sun B
Pathol Res Pract 2023 Sep;249:154755. Epub 2023 Aug 9 doi: 10.1016/j.prp.2023.154755. PMID: 37651837
Lacking Immunotherapy Biomarkers for Biliary Tract Cancer: A Comprehensive Systematic Literature Review and Meta-Analysis.
Frega G, Cossio FP, Banales JM, Cardinale V, Macias RIR, Braconi C, Lamarca A
Cells 2023 Aug 19;12(16) doi: 10.3390/cells12162098. PMID: 37626908Free PMC Article
Major complications and mortality after resection of intrahepatic cholangiocarcinoma: A systematic review and meta-analysis.
van Keulen AM, Büttner S, Erdmann JI, Hagendoorn J, Hoogwater FJH, IJzermans JNM, Neumann UP, Polak WG, De Jonge J, Olthof PB, Koerkamp BG
Surgery 2023 Apr;173(4):973-982. Epub 2022 Dec 27 doi: 10.1016/j.surg.2022.11.027. PMID: 36577599
Epidemiology, Natural History, and Outcomes of Primary Sclerosing Cholangitis: A Systematic Review of Population-based Studies.
Trivedi PJ, Bowlus CL, Yimam KK, Razavi H, Estes C
Clin Gastroenterol Hepatol 2022 Aug;20(8):1687-1700.e4. Epub 2021 Aug 30 doi: 10.1016/j.cgh.2021.08.039. PMID: 34474162
Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis.
Clements O, Eliahoo J, Kim JU, Taylor-Robinson SD, Khan SA
J Hepatol 2020 Jan;72(1):95-103. Epub 2019 Sep 16 doi: 10.1016/j.jhep.2019.09.007. PMID: 31536748

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