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Hepatocellular adenoma

MedGen UID:
61655
•Concept ID:
C0206669
•
Neoplastic Process
Synonyms: Adenoma, Hepatocellular; Adenoma, Liver Cell; Adenomas, Hepatocellular; Adenomas, Liver Cell; Benign Hepatoma; Benign Hepatomas; Hepatocellular Adenoma; Hepatocellular Adenomas; Hepatoma, Benign; Hepatomas, Benign; Liver Cell Adenoma; Liver Cell Adenomas
SNOMED CT: HCA - Hepatocellular adenoma (78058005); Benign hepatoma (78058005); Liver cell adenoma (78058005); Hepatocellular adenoma (78058005); Hepatoma, benign (78058005); Adenoma of liver (424263008); Hepatocellular adenoma (1156419009)
 
HPO: HP:0012028
Monarch Initiative: MONDO:0018902
Orphanet: ORPHA54272

Definition

A benign tumor of the liver of presumably epithelial origin. [from HPO]

Conditions with this feature

Hepatic adenomas, familial
MedGen UID:
374515
•Concept ID:
C1840646
•
Disease or Syndrome
See: Condition Record
Hepatic adenomas, familial

Professional guidelines

PubMed

ACG Clinical Guideline: Focal Liver Lesions.
Frenette C, Mendiratta-Lala M, Salgia R, Wong RJ, Sauer BG, Pillai A
Am J Gastroenterol 2024 Jul 1;119(7):1235-1271. Epub 2024 Jan 26 doi: 10.14309/ajg.0000000000002857. PMID: 38958301
Focal Nodular Hyperplasia and Hepatic Adenoma: Evaluation and Management.
Myers L, Ahn J
Clin Liver Dis 2020 Aug;24(3):389-403. Epub 2020 Jun 3 doi: 10.1016/j.cld.2020.04.013. PMID: 32620279
ACG clinical guideline: the diagnosis and management of focal liver lesions.
Marrero JA, Ahn J, Rajender Reddy K; Americal College of Gastroenterology
Am J Gastroenterol 2014 Sep;109(9):1328-47; quiz 1348. Epub 2014 Aug 19 doi: 10.1038/ajg.2014.213. PMID: 25135008

Recent clinical studies

Etiology

Hepatocellular adenoma: Where are we now?
Wang X, Zhang X
World J Gastroenterol 2022 Apr 14;28(14):1384-1393. doi: 10.3748/wjg.v28.i14.1384. PMID: 35582672Free PMC Article
Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Focal Nodular Hyperplasia and Hepatic Adenoma: Evaluation and Management.
Myers L, Ahn J
Clin Liver Dis 2020 Aug;24(3):389-403. Epub 2020 Jun 3 doi: 10.1016/j.cld.2020.04.013. PMID: 32620279
Advances in molecular classification and precision oncology in hepatocellular carcinoma.
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
Nault JC, Couchy G, Balabaud C, Morcrette G, Caruso S, Blanc JF, Bacq Y, Calderaro J, Paradis V, Ramos J, Scoazec JY, Gnemmi V, Sturm N, Guettier C, Fabre M, Savier E, Chiche L, Labrune P, Selves J, Wendum D, Pilati C, Laurent A, De Muret A, Le Bail B, Rebouissou S, Imbeaud S; GENTHEP Investigators, Bioulac-Sage P, Letouzé E, Zucman-Rossi J
Gastroenterology 2017 Mar;152(4):880-894.e6. Epub 2016 Dec 7 doi: 10.1053/j.gastro.2016.11.042. PMID: 27939373

Diagnosis

ACG Clinical Guideline: Focal Liver Lesions.
Frenette C, Mendiratta-Lala M, Salgia R, Wong RJ, Sauer BG, Pillai A
Am J Gastroenterol 2024 Jul 1;119(7):1235-1271. Epub 2024 Jan 26 doi: 10.14309/ajg.0000000000002857. PMID: 38958301
Focal Benign Liver Lesions and Their Diagnostic Pitfalls.
Reizine E, Mulé S, Luciani A
Radiol Clin North Am 2022 Sep;60(5):755-773. Epub 2022 Jul 4 doi: 10.1016/j.rcl.2022.05.005. PMID: 35989043
Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Application of Immunohistochemistry in the Pathological Diagnosis of Liver Tumors.
Takahashi Y, Dungubat E, Kusano H, Ganbat D, Tomita Y, Odgerel S, Fukusato T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115780. PMID: 34071338Free PMC Article
Focal Nodular Hyperplasia and Hepatic Adenoma: Evaluation and Management.
Myers L, Ahn J
Clin Liver Dis 2020 Aug;24(3):389-403. Epub 2020 Jun 3 doi: 10.1016/j.cld.2020.04.013. PMID: 32620279

Therapy

Large size and haemorrhage are not contraindications to laparoscopic resection of hepatocellular adenoma.
McKay B, Webber L, Manoharan B, Miller G, Clouston A, Bryant R, Cavallucci D, O'Rourke N
ANZ J Surg 2020 Jun;90(6):1099-1103. Epub 2020 Jan 26 doi: 10.1111/ans.15702. PMID: 31983071
Advances in molecular classification and precision oncology in hepatocellular carcinoma.
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Hepatocellular adenoma: An unsolved diagnostic enigma.
Renzulli M, Clemente A, Tovoli F, Cappabianca S, Bolondi L, Golfieri R
World J Gastroenterol 2019 May 28;25(20):2442-2449. doi: 10.3748/wjg.v25.i20.2442. PMID: 31171888Free PMC Article
Hepatocellular adenomatosis: what should the term stand for!
Frulio N, Chiche L, Bioulac-Sage P, Balabaud C
Clin Res Hepatol Gastroenterol 2014 Apr;38(2):132-6. Epub 2013 Oct 11 doi: 10.1016/j.clinre.2013.08.004. PMID: 24126236
Systematic review of hepatocellular adenoma in China and other regions.
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

Prognosis

The Human GP130 Cytokine Receptor and Its Expression-an Atlas and Functional Taxonomy of Genetic Variants.
Chen YH, van Zon S, Adams A, Schmidt-Arras D, Laurence ADJ, Uhlig HH
J Clin Immunol 2023 Dec 22;44(1):30. doi: 10.1007/s10875-023-01603-7. PMID: 38133879Free PMC Article
Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Hepatocellular adenoma in the paediatric population: Molecular classification and clinical associations.
Hahn E, Putra J
World J Gastroenterol 2020 May 21;26(19):2294-2304. doi: 10.3748/wjg.v26.i19.2294. PMID: 32476794Free PMC Article
Advances in molecular classification and precision oncology in hepatocellular carcinoma.
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Space Occupying Lesions in the Liver.
Thyagarajan MS, Sharif K
Indian J Pediatr 2016 Nov;83(11):1291-1302. Epub 2016 Oct 25 doi: 10.1007/s12098-016-2240-x. PMID: 27783314

Clinical prediction guides

Sonic hedgehog hepatocellular adenoma: magnetic resonance imaging features and correlation with histology.
Ducatel A, Trillaud H, Reizine E, Vilgrain V, Sempoux C, Schmidt-Kobbe S, Gouw ASH, de Haas RJ, Julien C, Paradis V, Blanc JF, Chiche L, Balabaud C, Bioulac-Sage P, Frulio N
Eur Radiol 2024 Jul;34(7):4649-4662. Epub 2023 Nov 28 doi: 10.1007/s00330-023-10344-5. PMID: 38012454
Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Hepatocellular adenomas: review of pathological and molecular features.
Beaufrère A, Paradis V
Hum Pathol 2021 Jun;112:128-137. Epub 2020 Dec 9 doi: 10.1016/j.humpath.2020.11.016. PMID: 33307077
Advances in molecular classification and precision oncology in hepatocellular carcinoma.
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Systematic review of hepatocellular adenoma in China and other regions.
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

Recent systematic reviews

Behavior and complications of hepatocellular adenoma during pregnancy and puerperium: a retrospective study and systematic review.
Haring MPD, Spijkerboer CS, Cuperus FJC, Duiker EW, de Jong KP, de Haas RJ, de Meijer VE
HPB (Oxford) 2021 Aug;23(8):1152-1163. Epub 2021 Apr 28 doi: 10.1016/j.hpb.2021.04.019. PMID: 33985906
Systematic review of transarterial embolization for hepatocellular adenomas.
van Rosmalen BV, Coelen RJS, Bieze M, van Delden OM, Verheij J, Dejong CHC, van Gulik TM
Br J Surg 2017 Jun;104(7):823-835. doi: 10.1002/bjs.10547. PMID: 28518415
Focal Nodular Hyperplasia and Hepatocellular Adenoma: Accuracy of Gadoxetic Acid-enhanced MR Imaging--A Systematic Review.
McInnes MD, Hibbert RM, Inácio JR, Schieda N
Radiology 2015 Nov;277(2):413-23. Epub 2015 May 26 doi: 10.1148/radiol.2015142986. PMID: 26020440
Systematic review of haemorrhage and rupture of hepatocellular adenomas.
van Aalten SM, de Man RA, IJzermans JN, Terkivatan T
Br J Surg 2012 Jul;99(7):911-6. Epub 2012 May 22 doi: 10.1002/bjs.8762. PMID: 22619025
Systematic review of hepatocellular adenoma in China and other regions.
Lin H, van den Esschert J, Liu C, van Gulik TM
J Gastroenterol Hepatol 2011 Jan;26(1):28-35. doi: 10.1111/j.1440-1746.2010.06502.x. PMID: 21175790

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