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Autoimmune disorder of the nervous system

MedGen UID:
155946
Concept ID:
C0751871
Disease or Syndrome
Synonym: Autoimmune disease of the nervous system
 
Monarch Initiative: MONDO:0002977

Definition

A disorder characterized by the degeneration of the nervous system due to autoimmunity. Representative examples include multiple sclerosis, Guillain-Barre syndrome, and myasthenia gravis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAutoimmune disorder of the nervous system

Professional guidelines

PubMed

van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol 2023 Dec;30(12):3646-3674. Epub 2023 Oct 10 doi: 10.1111/ene.16073. PMID: 37814552
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977

Recent clinical studies

Etiology

Kaur D, Tiwana H, Stino A, Sandroni P
Muscle Nerve 2021 Jan;63(1):10-21. Epub 2020 Sep 14 doi: 10.1002/mus.27048. PMID: 32926436
Geis C, Planagumà J, Carreño M, Graus F, Dalmau J
J Clin Invest 2019 Mar 1;129(3):926-940. Epub 2019 Feb 4 doi: 10.1172/JCI125178. PMID: 30714986Free PMC Article
Cotsapas C, Mitrovic M, Hafler D
Handb Clin Neurol 2018;148:723-730. doi: 10.1016/B978-0-444-64076-5.00046-6. PMID: 29478610
Toussirot É, Bereau M
Inflamm Allergy Drug Targets 2015;14(2):94-8. doi: 10.2174/1871528114666160105113046. PMID: 26728772
Compston A, Coles A
Lancet 2002 Apr 6;359(9313):1221-31. doi: 10.1016/S0140-6736(02)08220-X. PMID: 11955556

Diagnosis

Cacciaguerra L, Flanagan EP
Neurol Clin 2024 Feb;42(1):77-114. Epub 2023 Aug 7 doi: 10.1016/j.ncl.2023.06.009. PMID: 37980124Free PMC Article
Dalmau J, Graus F
Lancet Neurol 2023 Jun;22(6):529-540. doi: 10.1016/S1474-4422(23)00083-2. PMID: 37210100
Steck AJ
J Neuroimmunol 2021 Dec 15;361:577725. Epub 2021 Sep 28 doi: 10.1016/j.jneuroim.2021.577725. PMID: 34610502
Dade M, Berzero G, Izquierdo C, Giry M, Benazra M, Delattre JY, Psimaras D, Alentorn A
Int J Mol Sci 2020 May 24;21(10) doi: 10.3390/ijms21103701. PMID: 32456344Free PMC Article
Husari KS, Dubey D
Neurotherapeutics 2019 Jul;16(3):685-702. doi: 10.1007/s13311-019-00750-3. PMID: 31240596Free PMC Article

Therapy

Yang J, Liu X
Front Immunol 2021;12:790962. Epub 2021 Dec 16 doi: 10.3389/fimmu.2021.790962. PMID: 34975890Free PMC Article
Steck AJ
J Neuroimmunol 2021 Dec 15;361:577725. Epub 2021 Sep 28 doi: 10.1016/j.jneuroim.2021.577725. PMID: 34610502
Kaur D, Tiwana H, Stino A, Sandroni P
Muscle Nerve 2021 Jan;63(1):10-21. Epub 2020 Sep 14 doi: 10.1002/mus.27048. PMID: 32926436
Abel A, McClelland C, Lee MS
Surv Ophthalmol 2019 Nov-Dec;64(6):770-779. Epub 2019 Jun 20 doi: 10.1016/j.survophthal.2019.06.001. PMID: 31229520
Compston A, Coles A
Lancet 2002 Apr 6;359(9313):1221-31. doi: 10.1016/S0140-6736(02)08220-X. PMID: 11955556

Prognosis

Wu D, Luo Y, Li T, Zhao X, Lv T, Fang G, Ou P, Li H, Luo X, Huang A, Pang Y
Front Immunol 2022;13:1051082. Epub 2022 Dec 22 doi: 10.3389/fimmu.2022.1051082. PMID: 36618407Free PMC Article
Dade M, Berzero G, Izquierdo C, Giry M, Benazra M, Delattre JY, Psimaras D, Alentorn A
Int J Mol Sci 2020 May 24;21(10) doi: 10.3390/ijms21103701. PMID: 32456344Free PMC Article
Husari KS, Dubey D
Neurotherapeutics 2019 Jul;16(3):685-702. doi: 10.1007/s13311-019-00750-3. PMID: 31240596Free PMC Article
Abel A, McClelland C, Lee MS
Surv Ophthalmol 2019 Nov-Dec;64(6):770-779. Epub 2019 Jun 20 doi: 10.1016/j.survophthal.2019.06.001. PMID: 31229520
McKeon A, Tracy JA
Muscle Nerve 2017 Jul;56(1):15-27. Epub 2017 Apr 11 doi: 10.1002/mus.25565. PMID: 28063151

Clinical prediction guides

Dade M, Berzero G, Izquierdo C, Giry M, Benazra M, Delattre JY, Psimaras D, Alentorn A
Int J Mol Sci 2020 May 24;21(10) doi: 10.3390/ijms21103701. PMID: 32456344Free PMC Article
Husari KS, Dubey D
Neurotherapeutics 2019 Jul;16(3):685-702. doi: 10.1007/s13311-019-00750-3. PMID: 31240596Free PMC Article
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
McKeon A, Tracy JA
Muscle Nerve 2017 Jul;56(1):15-27. Epub 2017 Apr 11 doi: 10.1002/mus.25565. PMID: 28063151
Toussirot É, Bereau M
Inflamm Allergy Drug Targets 2015;14(2):94-8. doi: 10.2174/1871528114666160105113046. PMID: 26728772

Recent systematic reviews

Liampas A, Parperis K, Erotocritou MF, Nteveros A, Papadopoulou M, Moschovos C, Akil M, Coaccioli S, Hadjigeorgiou GM, Hadjivassiliou M, Zis P
Eur J Neurol 2023 Jan;30(1):255-265. Epub 2022 Sep 23 doi: 10.1111/ene.15555. PMID: 36086910Free PMC Article
Finsterer J
Int J Mol Sci 2022 Nov 17;23(22) doi: 10.3390/ijms232214222. PMID: 36430700Free PMC Article
Kim PS, Fishman MA
Curr Pain Headache Rep 2020 Aug 26;24(10):64. doi: 10.1007/s11916-020-00898-0. PMID: 32845365
Corvillo I, Varela E, Armijo F, Alvarez-Badillo A, Armijo O, Maraver F
Eur J Phys Rehabil Med 2017 Dec;53(6):944-952. Epub 2017 Feb 17 doi: 10.23736/S1973-9087.17.04570-1. PMID: 28215060
Beghi E, Carpio A, Forsgren L, Hesdorffer DC, Malmgren K, Sander JW, Tomson T, Hauser WA
Epilepsia 2010 Apr;51(4):671-5. Epub 2009 Sep 3 doi: 10.1111/j.1528-1167.2009.02285.x. PMID: 19732133

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