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Infectious meningitis

MedGen UID:
152668
•Concept ID:
C0729584
•
Disease or Syndrome
Synonyms: Infectious Meningitis; infectious meningitis; Infective meningitis; infective meningitis; meningitis
SNOMED CT: Infective meningitis (312216007)
 
Monarch Initiative: MONDO:0004796

Definition

Inflammation of the meninges of the brain and/or spinal cord caused by an infectious agent (viral, bacterial, or fungal). Symptoms include headache, fever, vomiting, neck stiffness, photophobia, confusion, and seizures. [from NCI]

Professional guidelines

PubMed

Emergency department management of adults with infectious meningitis and encephalitis.
Hogan AN, Brockman II CR, Santa Maria A
Emerg Med Pract 2022 Apr;24(4):1-24. Epub 2022 Apr 2 PMID: 35315604
Critical care management of infectious meningitis and encephalitis.
Meyfroidt G, Kurtz P, Sonneville R
Intensive Care Med 2020 Feb;46(2):192-201. Epub 2020 Jan 14 doi: 10.1007/s00134-019-05901-w. PMID: 31938828
Aseptic meningitis: diagnosis and management.
Kumar R
Indian J Pediatr 2005 Jan;72(1):57-63. doi: 10.1007/BF02760582. PMID: 15684450

Recent clinical studies

Etiology

Evaluation of metagenomic and pathogen-targeted next-generation sequencing for diagnosis of meningitis and encephalitis in adults: A multicenter prospective observational cohort study in China.
Chen W, Liu G, Cui L, Tian F, Zhang J, Zhao J, Lv Y, Du J, Huan X, Wu Y, Zhang Y
J Infect 2024 May;88(5):106143. Epub 2024 Mar 26 doi: 10.1016/j.jinf.2024.106143. PMID: 38548243
Global, regional, and national burden of meningitis and its aetiologies, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Meningitis Antimicrobial Resistance Collaborators
Lancet Neurol 2023 Aug;22(8):685-711. doi: 10.1016/S1474-4422(23)00195-3. PMID: 37479374Free PMC Article
Aseptic meningitis.
Tattevin P, Tchamgoué S, Belem A, Bénézit F, Pronier C, Revest M
Rev Neurol (Paris) 2019 Sep-Oct;175(7-8):475-480. Epub 2019 Jul 30 doi: 10.1016/j.neurol.2019.07.005. PMID: 31375286
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.
Wilson MR, Sample HA, Zorn KC, Arevalo S, Yu G, Neuhaus J, Federman S, Stryke D, Briggs B, Langelier C, Berger A, Douglas V, Josephson SA, Chow FC, Fulton BD, DeRisi JL, Gelfand JM, Naccache SN, Bender J, Dien Bard J, Murkey J, Carlson M, Vespa PM, Vijayan T, Allyn PR, Campeau S, Humphries RM, Klausner JD, Ganzon CD, Memar F, Ocampo NA, Zimmermann LL, Cohen SH, Polage CR, DeBiasi RL, Haller B, Dallas R, Maron G, Hayden R, Messacar K, Dominguez SR, Miller S, Chiu CY
N Engl J Med 2019 Jun 13;380(24):2327-2340. doi: 10.1056/NEJMoa1803396. PMID: 31189036Free PMC Article
Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens.
Leber AL, Everhart K, Balada-Llasat JM, Cullison J, Daly J, Holt S, Lephart P, Salimnia H, Schreckenberger PC, DesJarlais S, Reed SL, Chapin KC, LeBlanc L, Johnson JK, Soliven NL, Carroll KC, Miller JA, Dien Bard J, Mestas J, Bankowski M, Enomoto T, Hemmert AC, Bourzac KM
J Clin Microbiol 2016 Sep;54(9):2251-61. Epub 2016 Jun 22 doi: 10.1128/JCM.00730-16. PMID: 27335149Free PMC Article

Diagnosis

Infectious Meningitis and Encephalitis.
Bystritsky RJ, Chow FC
Neurol Clin 2022 Feb;40(1):77-91. doi: 10.1016/j.ncl.2021.08.006. PMID: 34798976
Meningitis.
Aksamit AJ Jr, Berkowitz AL
Continuum (Minneap Minn) 2021 Aug 1;27(4):836-854. doi: 10.1212/CON.0000000000001016. PMID: 34623095
Methods for rapid diagnosis of meningitis etiology in adults.
Poplin V, Boulware DR, Bahr NC
Biomark Med 2020 Apr;14(6):459-479. Epub 2020 Apr 9 doi: 10.2217/bmm-2019-0333. PMID: 32270693Free PMC Article
Aseptic meningitis.
Tattevin P, Tchamgoué S, Belem A, Bénézit F, Pronier C, Revest M
Rev Neurol (Paris) 2019 Sep-Oct;175(7-8):475-480. Epub 2019 Jul 30 doi: 10.1016/j.neurol.2019.07.005. PMID: 31375286
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.
Wilson MR, Sample HA, Zorn KC, Arevalo S, Yu G, Neuhaus J, Federman S, Stryke D, Briggs B, Langelier C, Berger A, Douglas V, Josephson SA, Chow FC, Fulton BD, DeRisi JL, Gelfand JM, Naccache SN, Bender J, Dien Bard J, Murkey J, Carlson M, Vespa PM, Vijayan T, Allyn PR, Campeau S, Humphries RM, Klausner JD, Ganzon CD, Memar F, Ocampo NA, Zimmermann LL, Cohen SH, Polage CR, DeBiasi RL, Haller B, Dallas R, Maron G, Hayden R, Messacar K, Dominguez SR, Miller S, Chiu CY
N Engl J Med 2019 Jun 13;380(24):2327-2340. doi: 10.1056/NEJMoa1803396. PMID: 31189036Free PMC Article

Therapy

Chronic Enterovirus Meningoencephalitis in Prolonged B-Cell Depletion After Rituximab Therapy: Case Report.
Jacksch C, Dargvainiene J, Böttcher S, Diedrich S, Leypoldt F, Stürner K, Berg D, Schäffer E
Neurol Neuroimmunol Neuroinflamm 2023 Nov;10(6) Epub 2023 Oct 9 doi: 10.1212/NXI.0000000000200171. PMID: 37813597Free PMC Article
Predictors of infectious meningitis or encephalitis: the yield of cerebrospinal fluid in a cross-sectional study.
Dittrich T, Marsch S, Egli A, Rüegg S, De Marchis GM, Tschudin-Sutter S, Sutter R
BMC Infect Dis 2020 Apr 23;20(1):304. doi: 10.1186/s12879-020-05022-6. PMID: 32326881Free PMC Article
Critical care management of infectious meningitis and encephalitis.
Meyfroidt G, Kurtz P, Sonneville R
Intensive Care Med 2020 Feb;46(2):192-201. Epub 2020 Jan 14 doi: 10.1007/s00134-019-05901-w. PMID: 31938828
Nonsteroidal anti-inflammatory drugs exposure and the central nervous system.
Auriel E, Regev K, Korczyn AD
Handb Clin Neurol 2014;119:577-84. doi: 10.1016/B978-0-7020-4086-3.00038-2. PMID: 24365321
The challenge of drug-induced aseptic meningitis.
Moris G, Garcia-Monco JC
Arch Intern Med 1999 Jun 14;159(11):1185-94. doi: 10.1001/archinte.159.11.1185. PMID: 10371226

Prognosis

Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis.
Xing Z, Jiang H, Liu X, Chai Q, Xin Z, Zhu C, Bao Y, Chen H, Gao H, Ma D
J Transl Med 2024 Jun 20;22(1):583. doi: 10.1186/s12967-024-05370-w. PMID: 38902725Free PMC Article
Reassessing the Value of CSF Protein and Glucose Measurement in Pediatric Infectious Meningitis.
McLaughlin WN, Lamb M, Gaensbauer J
Hosp Pediatr 2022 May 1;12(5):481-490. doi: 10.1542/hpeds.2021-006435. PMID: 35373285
Microbial aspects and potential markers for differentiation between bacterial and viral meningitis among adult patients.
Alnomasy SF, Alotaibi BS, Mujamammi AH, Hassan EA, Ali ME
PLoS One 2021;16(6):e0251518. Epub 2021 Jun 11 doi: 10.1371/journal.pone.0251518. PMID: 34115780Free PMC Article
Optimizing Laboratory Diagnostic Services for Infectious Meningitis in the Meningitis Belt of sub-Saharan Africa.
Okolie CE, Essien UC
ACS Infect Dis 2019 Dec 13;5(12):1980-1986. Epub 2019 Nov 18 doi: 10.1021/acsinfecdis.9b00340. PMID: 31738509
Infectious meningitis and encephalitis in adults in Denmark: a prospective nationwide observational cohort study (DASGIB).
Bodilsen J, Storgaard M, Larsen L, Wiese L, Helweg-Larsen J, Lebech AM, Brandt C, Østergaard C, Nielsen H; DASGIB study group
Clin Microbiol Infect 2018 Oct;24(10):1102.e1-1102.e5. Epub 2018 Mar 1 doi: 10.1016/j.cmi.2018.01.016. PMID: 29409994

Clinical prediction guides

Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis.
Xing Z, Jiang H, Liu X, Chai Q, Xin Z, Zhu C, Bao Y, Chen H, Gao H, Ma D
J Transl Med 2024 Jun 20;22(1):583. doi: 10.1186/s12967-024-05370-w. PMID: 38902725Free PMC Article
Evaluation of metagenomic and pathogen-targeted next-generation sequencing for diagnosis of meningitis and encephalitis in adults: A multicenter prospective observational cohort study in China.
Chen W, Liu G, Cui L, Tian F, Zhang J, Zhao J, Lv Y, Du J, Huan X, Wu Y, Zhang Y
J Infect 2024 May;88(5):106143. Epub 2024 Mar 26 doi: 10.1016/j.jinf.2024.106143. PMID: 38548243
Reassessing the Value of CSF Protein and Glucose Measurement in Pediatric Infectious Meningitis.
McLaughlin WN, Lamb M, Gaensbauer J
Hosp Pediatr 2022 May 1;12(5):481-490. doi: 10.1542/hpeds.2021-006435. PMID: 35373285
Microbial aspects and potential markers for differentiation between bacterial and viral meningitis among adult patients.
Alnomasy SF, Alotaibi BS, Mujamammi AH, Hassan EA, Ali ME
PLoS One 2021;16(6):e0251518. Epub 2021 Jun 11 doi: 10.1371/journal.pone.0251518. PMID: 34115780Free PMC Article
Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens.
Leber AL, Everhart K, Balada-Llasat JM, Cullison J, Daly J, Holt S, Lephart P, Salimnia H, Schreckenberger PC, DesJarlais S, Reed SL, Chapin KC, LeBlanc L, Johnson JK, Soliven NL, Carroll KC, Miller JA, Dien Bard J, Mestas J, Bankowski M, Enomoto T, Hemmert AC, Bourzac KM
J Clin Microbiol 2016 Sep;54(9):2251-61. Epub 2016 Jun 22 doi: 10.1128/JCM.00730-16. PMID: 27335149Free PMC Article

Recent systematic reviews

Global, regional, and national burden of meningitis and its aetiologies, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Meningitis Antimicrobial Resistance Collaborators
Lancet Neurol 2023 Aug;22(8):685-711. doi: 10.1016/S1474-4422(23)00195-3. PMID: 37479374Free PMC Article

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