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Haemophilus meningitis

MedGen UID:
7535
•Concept ID:
C0025292
•
Disease or Syndrome
Synonyms: Haemophilus Meningitides; Haemophilus Meningitis; Hemophilus Meningitides; Hemophilus Meningitis; Meningitides, Haemophilus; Meningitides, Hemophilus; Meningitis, Haemophilus; Meningitis, Hemophilus
SNOMED CT: Haemophilus meningitis (192643004)
 
Monarch Initiative: MONDO:0000889

Definition

Infections of the nervous system caused by bacteria of the genus haemophilus, and marked by prominent inflammation of the meninges. haemophilus influenzae type B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHaemophilus meningitis

Professional guidelines

PubMed

BRAIN SWELLING WITH ACUTE PURULENT MENINGITIS. REPORT OF TREATMENT WITH HYPERTONIC INTRAVENOUS UREA.
WILLIAMS CP, SWANSON AG, CHAPMAN JT
Pediatrics 1964 Aug;34:220-7. PMID: 14211082
HYPERSENSITIVITY--ARTHRITIS AS A COMPLICATION TO TREATMENT WITH 3,4,DIMETHYL-5-SULFANILAMIDOISOXAZOL (GANTRISIN, SULFOXOL).
BACKMAN A
Ann Paediatr Fenn 1964;10:238-41. PMID: 14166254
AMPICILLIN IN THE TREATMENT OF ACUTE BACTERIAL MENINGITIS.
IVLER D, THRUPP LD, LEEDOM JM, WEHRLE PF, PORTNOY B
Antimicrob Agents Chemother (Bethesda) 1963;161:335-45. PMID: 14274920

Recent clinical studies

Etiology

Haemophilus influenzae type B disease, vaccines, and care of exposed individuals.
Burns IT, Zimmerman RK
J Fam Pract 2000 Sep;49(9 Suppl):S7-13; quiz S14. PMID: 11032188
Prophylaxis of bacterial meningitis.
Peltola H
Infect Dis Clin North Am 1999 Sep;13(3):685-710, viii. doi: 10.1016/s0891-5520(05)70101-x. PMID: 10470562
Bacterial meningitis--1982.
Gold R
Am J Med 1983 Jul 28;75(1B):98-101. doi: 10.1016/0002-9343(83)90079-7. PMID: 6349348
Corticosteroids as adjunctive therapy for acute bacterial meningitis.
Harbin GL, Hodges GR
South Med J 1979 Aug;72(8):977-80. doi: 10.1097/00007611-197908000-00024. PMID: 382381
Is Haemophilus influenzae meningitis contagious?
Smith AL
N Engl J Med 1979 Jul 19;301(3):155-6. doi: 10.1056/NEJM197907193010309. PMID: 313005

Diagnosis

Haemophilus influenzae type B disease, vaccines, and care of exposed individuals.
Burns IT, Zimmerman RK
J Fam Pract 2000 Sep;49(9 Suppl):S7-13; quiz S14. PMID: 11032188
Bacterial meningitis--1982.
Gold R
Am J Med 1983 Jul 28;75(1B):98-101. doi: 10.1016/0002-9343(83)90079-7. PMID: 6349348
Hemophilus influenzae infections: part II.
Riley HD Jr
Crit Rev Clin Lab Sci 1981;15(4):277-333. doi: 10.3109/10408368109105873. PMID: 7032843
Bacterial meningitis--1978.
Underman AE, Overturf GD, Leedom JM
Dis Mon 1978 Feb;24(5):1-63. doi: 10.1016/s0011-5029(78)80003-0. PMID: 376254
Hemophilus influenzae infections in adults.
Norden CW
Med Clin North Am 1978 Sep;62(5):1037-46. doi: 10.1016/s0025-7125(16)31753-9. PMID: 366294

Therapy

Glycoconjugate vaccines: an update.
Vella M, Pace D
Expert Opin Biol Ther 2015 Apr;15(4):529-46. Epub 2014 Dec 11 doi: 10.1517/14712598.2015.993375. PMID: 25496172
Chemoprophylaxis of meningitis.
Jones DM
Trans R Soc Trop Med Hyg 1991;85 Suppl 1:44-5. doi: 10.1016/0035-9203(91)90340-5. PMID: 1803697
Steroids in meningitis.
Tarlow MJ, McCracken GH
Br J Hosp Med 1989 Nov;42(5):358. PMID: 2597823
Chemoprophylaxis of meningitis.
Smith H
Arch Dis Child 1986 Jan;61(1):4-5. doi: 10.1136/adc.61.1.4. PMID: 3954417Free PMC Article
Prophylaxis in haemophilus meningitis.
Lambert HP
Br Med J (Clin Res Ed) 1984 Mar 10;288(6419):739-40. doi: 10.1136/bmj.288.6419.739. PMID: 6423058Free PMC Article

Prognosis

Epidemiology of invasive Haemophilus influenzae type b disease.
Mäkelä PH, Takala AK, Peltola H, Eskola J
J Infect Dis 1992 Jun;165 Suppl 1:S2-6. doi: 10.1093/infdis/165.supplement_1-s2. PMID: 1588164
Brain edema and increased intracranial pressure in the pathophysiology of bacterial meningitis.
Niemöller UM, Täuber MG
Eur J Clin Microbiol Infect Dis 1989 Feb;8(2):109-17. doi: 10.1007/BF01963892. PMID: 2498090
Hemophilus influenzae infections: part II.
Riley HD Jr
Crit Rev Clin Lab Sci 1981;15(4):277-333. doi: 10.3109/10408368109105873. PMID: 7032843
Bacterial meningitis--1978.
Underman AE, Overturf GD, Leedom JM
Dis Mon 1978 Feb;24(5):1-63. doi: 10.1016/s0011-5029(78)80003-0. PMID: 376254
Bacterial meningitis.
Nankervis GA
Med Clin North Am 1974 May;58(3):581-92. doi: 10.1016/s0025-7125(16)32145-9. PMID: 4493707

Clinical prediction guides

Impact of Haemophilus influenzae type b vaccination on the incidence of invasive Haemophilus influenzae disease in France, 15 years after its introduction.
Georges S, Lepoutre A, Dabernat H, Levy-Bruhl D
Epidemiol Infect 2013 Sep;141(9):1787-96. Epub 2013 Feb 21 doi: 10.1017/S0950268813000083. PMID: 23425638Free PMC Article
Interleukin-1 production in bacterial meningitis.
Helminen M, Vesikari T
Scand J Infect Dis 1990;22(1):105-8. doi: 10.3109/00365549009023128. PMID: 2320958
Haemophilus influenzae meningitis with prolonged hospital course.
Martin LD, Kaplan AM, Rudinsky MF, Frost MD
Pediatr Neurol 1990 Jul-Aug;6(4):260-4. doi: 10.1016/0887-8994(90)90118-k. PMID: 2206158
Haemophilus influenzae type b infections in day care attendees: implications for management.
Daum RS, Granoff DM, Gilsdorf J, Murphy T, Osterholm MT
Rev Infect Dis 1986 Jul-Aug;8(4):558-67. doi: 10.1093/clinids/8.4.558. PMID: 3529311
Ischemic cerebrovascular complications of Haemophilus influenzae meningitis. The value of computed tomography.
Dunn DW, Daum RS, Weisberg L, Vargas R
Arch Neurol 1982 Oct;39(10):650-2. doi: 10.1001/archneur.1982.00510220048011. PMID: 7125976

Recent systematic reviews

Efficacy and Prolonged Safety of Haemophilus influenzae Type b Conjugate Vaccines.
Tripathi N, Mukherjee S
Infect Disord Drug Targets 2024;24(5):e150124225640. doi: 10.2174/0118715265269877231117070051. PMID: 38231056
Estimating the global and regional burden of meningitis in children caused by Haemophilus influenzae type b: A systematic review and meta-analysis.
Park JJ, Narayanan S, Tiefenbach J, Lukšić I, Ale BM, Adeloye D, Rudan I
J Glob Health 2022;12:04014. Epub 2022 Mar 5 doi: 10.7189/jogh.12.04014. PMID: 35265327Free PMC Article
Incidence and aetiology of bacterial meningitis among children aged 1-59 months in South Asia: systematic review and meta-analysis.
Ali M, Chang BA, Johnson KW, Morris SK
Vaccine 2018 Sep 18;36(39):5846-5857. Epub 2018 Aug 23 doi: 10.1016/j.vaccine.2018.07.037. PMID: 30145101
The effect of Haemophilus influenzae type B and pneumococcal conjugate vaccines on childhood meningitis mortality: a systematic review.
Davis S, Feikin D, Johnson HL
BMC Public Health 2013;13 Suppl 3(Suppl 3):S21. Epub 2013 Sep 17 doi: 10.1186/1471-2458-13-S3-S21. PMID: 24564188Free PMC Article

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