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Inner ear disorder

MedGen UID:
141671
•Concept ID:
C0494559
•
Disease or Syndrome
Synonym: Inner ear disease
SNOMED CT: Disorder of inner ear (232297009)
 
Monarch Initiative: MONDO:0002467

Definition

A non-neoplastic or neoplastic disorder affecting the inner ear. Causes are inner ear infections, head injuries, and neoplasms (e.g., acoustic schwannoma). Symptoms include dizziness, imbalance, nausea, and vision problems. [from NCI]

Professional guidelines

PubMed

Surgical Management of Intractable Meniere's Disease.
Luca P, Ralli M, Cassandro C, Russo FY, Gioacchini FM, Cavaliere M, Fiore M, Greco A, Cassandro E, Scarpa A
Int Tinnitus J 2022 Jun 21;26(1):50-56. doi: 10.5935/0946-5448.20220007. PMID: 35861458
Vestibular Neuritis: Recent Advances in Etiology, Diagnostic Evaluation, and Treatment.
Le TN, Westerberg BD, Lea J
Adv Otorhinolaryngol 2019;82:87-92. Epub 2019 Jan 15 doi: 10.1159/000490275. PMID: 30947184
Restriction of salt, caffeine and alcohol intake for the treatment of Ménière's disease or syndrome.
Hussain K, Murdin L, Schilder AG
Cochrane Database Syst Rev 2018 Dec 31;12(12):CD012173. doi: 10.1002/14651858.CD012173.pub2. PMID: 30596397Free PMC Article

Recent clinical studies

Etiology

Vitamin D Supplementation and Recurrence of Benign Paroxysmal Positional Vertigo.
Rhim G, Kim MJ
Nutrients 2024 Feb 28;16(5) doi: 10.3390/nu16050689. PMID: 38474817Free PMC Article
Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease.
Flook M, Rojano E, Gallego-Martinez A, Escalera-Balsera A, Perez-Carpena P, Moleon MDC, Gonzalez-Aguado R, Rivero de Jesus V, Domínguez-Durán E, Frejo L, G Ranea JA, Lopez-Escamez JA
Genes Immun 2024 Apr;25(2):124-131. Epub 2024 Feb 23 doi: 10.1038/s41435-024-00260-z. PMID: 38396174Free PMC Article
Idiopathic Labyrinthitis: Symptoms, Clinical Characteristics, and Prognosis.
Oussoren FK, Schermer TR, Bruintjes TD, Leeuwen RBV
J Int Adv Otol 2023 Nov;19(6):478-484. doi: 10.5152/iao.2023.231096. PMID: 38088320Free PMC Article
Transcanal Transvestibular Endoscopic Neurectomy: First Experience.
Marchioni D, Caiazza N, Calabrese C, Soloperto D
Otol Neurotol 2022 Feb 1;43(2):263-267. doi: 10.1097/MAO.0000000000003397. PMID: 35015752
Endolymphatic hydrops and ionic transporters: genetic and biohumoral aspects.
Teggi R, Carpini SD, Zagato L
J Neurol 2019 Sep;266(Suppl 1):47-51. Epub 2019 Jun 5 doi: 10.1007/s00415-019-09399-6. PMID: 31165925

Diagnosis

Idiopathic Labyrinthitis: Symptoms, Clinical Characteristics, and Prognosis.
Oussoren FK, Schermer TR, Bruintjes TD, Leeuwen RBV
J Int Adv Otol 2023 Nov;19(6):478-484. doi: 10.5152/iao.2023.231096. PMID: 38088320Free PMC Article
Potential nanotechnology-based diagnostic and therapeutic approaches for Meniere's disease.
Kashizadeh A, Pastras C, Rabiee N, Mohseni-Dargah M, Mukherjee P, Asadnia M
Nanomedicine 2022 Nov;46:102599. Epub 2022 Sep 5 doi: 10.1016/j.nano.2022.102599. PMID: 36064032
Surgical Management of Intractable Meniere's Disease.
Luca P, Ralli M, Cassandro C, Russo FY, Gioacchini FM, Cavaliere M, Fiore M, Greco A, Cassandro E, Scarpa A
Int Tinnitus J 2022 Jun 21;26(1):50-56. doi: 10.5935/0946-5448.20220007. PMID: 35861458
Vestibular Neuritis: Recent Advances in Etiology, Diagnostic Evaluation, and Treatment.
Le TN, Westerberg BD, Lea J
Adv Otorhinolaryngol 2019;82:87-92. Epub 2019 Jan 15 doi: 10.1159/000490275. PMID: 30947184
Otologic disorders causing dizziness, including surgery for vestibular disorders.
Bertholon P, Karkas A
Handb Clin Neurol 2016;137:279-93. doi: 10.1016/B978-0-444-63437-5.00020-0. PMID: 27638078

Therapy

Vitamin D Supplementation and Recurrence of Benign Paroxysmal Positional Vertigo.
Rhim G, Kim MJ
Nutrients 2024 Feb 28;16(5) doi: 10.3390/nu16050689. PMID: 38474817Free PMC Article
Transcanal Transvestibular Endoscopic Neurectomy: First Experience.
Marchioni D, Caiazza N, Calabrese C, Soloperto D
Otol Neurotol 2022 Feb 1;43(2):263-267. doi: 10.1097/MAO.0000000000003397. PMID: 35015752
Vestibular Neuritis: Recent Advances in Etiology, Diagnostic Evaluation, and Treatment.
Le TN, Westerberg BD, Lea J
Adv Otorhinolaryngol 2019;82:87-92. Epub 2019 Jan 15 doi: 10.1159/000490275. PMID: 30947184
Are diuretics effective for Ménière`s disease?
Rosenbaum A, Winter M
Medwave 2018 Mar 28;18(2):e7188. doi: 10.5867/medwave.2018.02.7187. PMID: 29624570
Is betahistine effective for Ménière’s disease?
Rosenbaum A, Winter M
Medwave 2017 Oct 31;17(8):e7068. doi: 10.5867/medwave.2017.08.7068. PMID: 29099816

Prognosis

Idiopathic Labyrinthitis: Symptoms, Clinical Characteristics, and Prognosis.
Oussoren FK, Schermer TR, Bruintjes TD, Leeuwen RBV
J Int Adv Otol 2023 Nov;19(6):478-484. doi: 10.5152/iao.2023.231096. PMID: 38088320Free PMC Article
A finite element model to predict the consequences of endolymphatic hydrops in the basilar membrane.
Areias B, Parente MPL, Gentil F, Caroça C, Paço J, Natal Jorge RM
Int J Numer Method Biomed Eng 2022 Jan;38(1):e3541. Epub 2021 Nov 3 doi: 10.1002/cnm.3541. PMID: 34697909
Vertigo without cochlear symptoms: vestibular migraine or Menière disease?
Teggi R, Familiari M, Gatti O, Bussi M
Neurol Sci 2021 Dec;42(12):5071-5076. Epub 2021 Mar 25 doi: 10.1007/s10072-021-05215-0. PMID: 33768434
Immune-mediated inner-ear disorders in neuro-otology.
Agrup C, Luxon LM
Curr Opin Neurol 2006 Feb;19(1):26-32. doi: 10.1097/01.wco.0000194143.02171.46. PMID: 16415674
Cochlear function in ears with immunomediated inner ear disorder.
Quaranta A, Scaringi A, Sallustio V, Quaranta N
Acta Otolaryngol Suppl 2002;(548):15-9. doi: 10.1080/00016480260094910. PMID: 12211350

Clinical prediction guides

Idiopathic Labyrinthitis: Symptoms, Clinical Characteristics, and Prognosis.
Oussoren FK, Schermer TR, Bruintjes TD, Leeuwen RBV
J Int Adv Otol 2023 Nov;19(6):478-484. doi: 10.5152/iao.2023.231096. PMID: 38088320Free PMC Article
Characterizing a Joint Reflection-Distortion OAE Profile in Humans With Endolymphatic Hydrops.
Stiepan S, Shera CA, Abdala C
Ear Hear 2023 Nov-Dec 01;44(6):1437-1450. Epub 2023 Jul 14 doi: 10.1097/AUD.0000000000001387. PMID: 37450653Free PMC Article
Correlations of Clinical and Audio-Vestibulometric Findings with Coexisting Anxiety and Depression in Ménière's Disease Patients.
Subasi B, Yildirim N, Akbey ZY, Karaman NE, Arik O
Audiol Neurootol 2023;28(2):75-83. Epub 2023 Jan 19 doi: 10.1159/000528421. PMID: 36657409
Transcanal Transvestibular Endoscopic Neurectomy: First Experience.
Marchioni D, Caiazza N, Calabrese C, Soloperto D
Otol Neurotol 2022 Feb 1;43(2):263-267. doi: 10.1097/MAO.0000000000003397. PMID: 35015752
A finite element model to predict the consequences of endolymphatic hydrops in the basilar membrane.
Areias B, Parente MPL, Gentil F, Caroça C, Paço J, Natal Jorge RM
Int J Numer Method Biomed Eng 2022 Jan;38(1):e3541. Epub 2021 Nov 3 doi: 10.1002/cnm.3541. PMID: 34697909

Recent systematic reviews

Systematic Review of Sequencing Studies and Gene Expression Profiling in Familial Meniere Disease.
Escalera-Balsera A, Roman-Naranjo P, Lopez-Escamez JA
Genes (Basel) 2020 Nov 27;11(12) doi: 10.3390/genes11121414. PMID: 33260921Free PMC Article
Restriction of salt, caffeine and alcohol intake for the treatment of Ménière's disease or syndrome.
Hussain K, Murdin L, Schilder AG
Cochrane Database Syst Rev 2018 Dec 31;12(12):CD012173. doi: 10.1002/14651858.CD012173.pub2. PMID: 30596397Free PMC Article

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