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Alphavirus infectious disease

MedGen UID:: 64650
•Concept ID:: C0206752
•: Disease or Syndrome

Synonyms:	Alpha Virus Infection; Alpha Virus Infections; Alphavirus Infection; Alphavirus Infections; Infection, Alphavirus; Infections, Alphavirus; Virus Infection, Alpha
SNOMED CT:	Alphavirus disease (4003003); Disease caused by Alphavirus (4003003)

Monarch Initiative:	MONDO:0005643

Definition

Virus diseases caused by members of the alphavirus genus of the family togaviridae. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAlphavirus infectious disease

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Cause
    - Infection
      - Vector-borne disease
        Arbovirus infection
        Alphavirus infectious disease
        Chikungunya fever
        Encephalomyelitis, Equine
        Eastern equine encephalitis
        Venezuelan equine encephalitis virus infection
        Western equine encephalitis

Professional guidelines

PubMed

The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19).

Pagliano P, Sellitto C, Ascione T, Scarpati G, Folliero V, Piazza O, Franci G, Filippelli A, Conti V
Expert Opin Drug Discov 2022 Dec;17(12):1299-1311. Epub 2022 Dec 12 doi: 10.1080/17460441.2022.2153828. PMID: 36508255

Chikungunya: Epidemiology, Pathogenesis, Clinical Features, Management, and Prevention.

Vairo F, Haider N, Kock R, Ntoumi F, Ippolito G, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1003-1025. doi: 10.1016/j.idc.2019.08.006. PMID: 31668189

Emergence and treatment of chikungunya arthritis.

Sutaria RB, Amaral JK, Schoen RT
Curr Opin Rheumatol 2018 May;30(3):256-263. doi: 10.1097/BOR.0000000000000486. PMID: 29389830

See all (18)

Recent clinical studies

Etiology

Chikungunya fever.

Bartholomeeusen K, Daniel M, LaBeaud DA, Gasque P, Peeling RW, Stephenson KE, Ng LFP, Ariën KK
Nat Rev Dis Primers 2023 Apr 6;9(1):17. doi: 10.1038/s41572-023-00429-2. PMID: 37024497 Free PMC Article

Chikungunya: risks for travellers.

Simon F, Caumes E, Jelinek T, Lopez-Velez R, Steffen R, Chen LH
J Travel Med 2023 Apr 5;30(2) doi: 10.1093/jtm/taad008. PMID: 36648431 Free PMC Article

Infectious mimics of rheumatoid arthritis.

Sharma V, Sharma A
Best Pract Res Clin Rheumatol 2022 Mar;36(1):101736. Epub 2021 Dec 31 doi: 10.1016/j.berh.2021.101736. PMID: 34974970

Chikungunya virus and autoimmunity.

Tanay A
Curr Opin Rheumatol 2017 Jul;29(4):389-393. doi: 10.1097/BOR.0000000000000396. PMID: 28376065

Alphaviruses.

Powers AM, Roehrig JT
Methods Mol Biol 2011;665:17-38. doi: 10.1007/978-1-60761-817-1_2. PMID: 21116793

See all (287)

Diagnosis

Infectious mimics of rheumatoid arthritis.

Sharma V, Sharma A
Best Pract Res Clin Rheumatol 2022 Mar;36(1):101736. Epub 2021 Dec 31 doi: 10.1016/j.berh.2021.101736. PMID: 34974970

Metagenomic sequencing with spiked primer enrichment for viral diagnostics and genomic surveillance.

Deng X, Achari A, Federman S, Yu G, Somasekar S, Bártolo I, Yagi S, Mbala-Kingebeni P, Kapetshi J, Ahuka-Mundeke S, Muyembe-Tamfum JJ, Ahmed AA, Ganesh V, Tamhankar M, Patterson JL, Ndembi N, Mbanya D, Kaptue L, McArthur C, Muñoz-Medina JE, Gonzalez-Bonilla CR, López S, Arias CF, Arevalo S, Miller S, Stone M, Busch M, Hsieh K, Messenger S, Wadford DA, Rodgers M, Cloherty G, Faria NR, Thézé J, Pybus OG, Neto Z, Morais J, Taveira N, R Hackett J Jr, Chiu CY
Nat Microbiol 2020 Mar;5(3):443-454. Epub 2020 Jan 13 doi: 10.1038/s41564-019-0637-9. PMID: 31932713 Free PMC Article

Chikungunya: Epidemiology, Pathogenesis, Clinical Features, Management, and Prevention.

Vairo F, Haider N, Kock R, Ntoumi F, Ippolito G, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1003-1025. doi: 10.1016/j.idc.2019.08.006. PMID: 31668189

Chikungunya virus infection: an overview.

Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863

Arthritogenic alphaviruses--an overview.

Suhrbier A, Jaffar-Bandjee MC, Gasque P
Nat Rev Rheumatol 2012 May 8;8(7):420-9. doi: 10.1038/nrrheum.2012.64. PMID: 22565316

See all (284)

Therapy

Infectious mimics of rheumatoid arthritis.

Sharma V, Sharma A
Best Pract Res Clin Rheumatol 2022 Mar;36(1):101736. Epub 2021 Dec 31 doi: 10.1016/j.berh.2021.101736. PMID: 34974970

A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice.

de Alwis R, Gan ES, Chen S, Leong YS, Tan HC, Zhang SL, Yau C, Low JGH, Kalimuddin S, Matsuda D, Allen EC, Hartman P, Park KJ, Alayyoubi M, Bhaskaran H, Dukanovic A, Bao Y, Clemente B, Vega J, Roberts S, Gonzalez JA, Sablad M, Yelin R, Taylor W, Tachikawa K, Parker S, Karmali P, Davis J, Sullivan BM, Sullivan SM, Hughes SG, Chivukula P, Ooi EE
Mol Ther 2021 Jun 2;29(6):1970-1983. Epub 2021 Apr 5 doi: 10.1016/j.ymthe.2021.04.001. PMID: 33823303 Free PMC Article

Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA.

Blakney AK, McKay PF, Bouton CR, Hu K, Samnuan K, Shattock RJ
Mol Ther 2021 Mar 3;29(3):1174-1185. Epub 2020 Dec 21 doi: 10.1016/j.ymthe.2020.11.011. PMID: 33352107 Free PMC Article

Chikungunya arthritis.

Pathak H, Mohan MC, Ravindran V
Clin Med (Lond) 2019 Sep;19(5):381-385. doi: 10.7861/clinmed.2019-0035. PMID: 31530685 Free PMC Article

Emerging viral infections.

Bale JF Jr
Semin Pediatr Neurol 2012 Sep;19(3):152-7. doi: 10.1016/j.spen.2012.02.001. PMID: 22889544 Free PMC Article

See all (130)

Prognosis

Genetic control of alphavirus pathogenesis.

Baxter VK, Heise MT
Mamm Genome 2018 Aug;29(7-8):408-424. Epub 2018 Aug 27 doi: 10.1007/s00335-018-9776-1. PMID: 30151711 Free PMC Article

Chikungunya virus and autoimmunity.

Tanay A
Curr Opin Rheumatol 2017 Jul;29(4):389-393. doi: 10.1097/BOR.0000000000000396. PMID: 28376065

Chikungunya.

MacFadden DR, Bogoch II
CMAJ 2014 Jul 8;186(10):775. Epub 2014 Jun 9 doi: 10.1503/cmaj.140031. PMID: 24914111 Free PMC Article

Emerging viral infections.

Bale JF Jr
Semin Pediatr Neurol 2012 Sep;19(3):152-7. doi: 10.1016/j.spen.2012.02.001. PMID: 22889544 Free PMC Article

Arthritogenic alphaviruses--an overview.

Suhrbier A, Jaffar-Bandjee MC, Gasque P
Nat Rev Rheumatol 2012 May 8;8(7):420-9. doi: 10.1038/nrrheum.2012.64. PMID: 22565316

See all (142)

Clinical prediction guides

Clinical Manifestations and Outcomes in Disease-Modifying Antirheumatic Drug-Naive Adult Patients with Chronic Chikungunya Arthritis.

Medina-Cintrón N, Martínez I, Pérez-Ríos N, Berríos-López Y, Vilá LM
Am J Trop Med Hyg 2021 Mar 8;104(5):1741-1746. doi: 10.4269/ajtmh.20-1573. PMID: 33684065 Free PMC Article

Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA.

Blakney AK, McKay PF, Bouton CR, Hu K, Samnuan K, Shattock RJ
Mol Ther 2021 Mar 3;29(3):1174-1185. Epub 2020 Dec 21 doi: 10.1016/j.ymthe.2020.11.011. PMID: 33352107 Free PMC Article

How great is the threat of chikungunya virus?

Waggoner JJ, Pinsky BA
Expert Rev Anti Infect Ther 2015 Mar;13(3):291-3. Epub 2014 Dec 24 doi: 10.1586/14787210.2015.995634. PMID: 25537007 Free PMC Article

Chikungunya virus infection: an overview.

Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863

Chikungunya virus: host pathogen interaction.

Singh SK, Unni SK
Rev Med Virol 2011 Mar;21(2):78-88. Epub 2011 Mar 15 doi: 10.1002/rmv.681. PMID: 21412934

See all (204)

Recent systematic reviews

Associations between temperature and Ross river virus infection: A systematic review and meta-analysis of epidemiological evidence.

Damtew YT, Tong M, Varghese BM, Hansen A, Liu J, Dear K, Zhang Y, Morgan G, Driscoll T, Capon T, Bi P
Acta Trop 2022 Jul;231:106454. Epub 2022 Apr 9 doi: 10.1016/j.actatropica.2022.106454. PMID: 35405101

Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis.

Contopoulos-Ioannidis D, Newman-Lindsay S, Chow C, LaBeaud AD
PLoS Negl Trop Dis 2018 Jun;12(6):e0006510. Epub 2018 Jun 13 doi: 10.1371/journal.pntd.0006510. PMID: 29897898 Free PMC Article

The neurological complications of chikungunya virus: A systematic review.

Mehta R, Gerardin P, de Brito CAA, Soares CN, Ferreira MLB, Solomon T
Rev Med Virol 2018 May;28(3):e1978. Epub 2018 Apr 19 doi: 10.1002/rmv.1978. PMID: 29671914 Free PMC Article

Prevalence of chronic comorbidities in chikungunya: A systematic review and meta-analysis.

Badawi A, Ryoo SG, Vasileva D, Yaghoubi S
Int J Infect Dis 2018 Feb;67:107-113. Epub 2017 Dec 20 doi: 10.1016/j.ijid.2017.12.018. PMID: 29277382 Free PMC Article

Urban Chikungunya in the Middle East and North Africa: A systematic review.

Humphrey JM, Cleton NB, Reusken CBEM, Glesby MJ, Koopmans MPG, Abu-Raddad LJ
PLoS Negl Trop Dis 2017 Jun;11(6):e0005707. Epub 2017 Jun 26 doi: 10.1371/journal.pntd.0005707. PMID: 28651007 Free PMC Article

See all (20)

MedGen

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Alphavirus infectious disease

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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