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Eastern equine encephalitis

MedGen UID:
102258
Concept ID:
C0153065
Disease or Syndrome
Synonyms: Eastern Equine Encephalitides; Eastern Equine Encephalitis; Eastern Equine Encephalomyelitides; Eastern Equine Encephalomyelitis; Eastern Equine Encephalomyelitis Virus Infection; Encephalitides, Eastern Equine; Encephalitis, Eastern Equine; Encephalomyelitides, Eastern Equine; Encephalomyelitis, Eastern Equine; Equine Encephalitides, Eastern; Equine Encephalitis, Eastern; Equine Encephalomyelitides, Eastern; Equine Encephalomyelitis, Eastern
SNOMED CT: Eastern equine encephalitis virus neuroinvasive disease (417496004); Eastern equine encephalitis virus infection (416925005); EEE - Eastern equine encephalitis (417496004); Eastern equine encephalomyelitis (417496004); Neuroinvasive Eastern equine encephalitis virus infection (417496004); Neuroinvasive Eastern equine encephalitis virus disease (417496004); Encephalitis, Eastern equine (416925005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005736
Orphanet: ORPHA83594

Definition

An acute arboviral infection caused by an <i>alphavirus</i> of the <i>Togaviridae</i> family transmitted by an infected mosquito, that is characterized by the onset of flulike symptoms including fever, chills, weakness, headache, vomiting, abdominal pain with diarrhea, myalgia, leucocytosis, and hematuria, rapidly progressing to diffuse central nervous system (CNS) involvement with confusion, somnolence, or even coma. Seizures, which may progress to status epilepticus and neurologic sequelae, cranial nerve palsies, and photophobia may occur. EEE is associated with a high rate of morbidity and mortality. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEastern equine encephalitis

Professional guidelines

PubMed

Zubair AS, McAlpine LS, Gobeske KT
J Neurol Sci 2024 Feb 15;457:122886. Epub 2024 Jan 13 doi: 10.1016/j.jns.2024.122886. PMID: 38278094
Aksamit AJ Jr
Neurol Clin 2021 Feb;39(1):197-207. Epub 2020 Nov 7 doi: 10.1016/j.ncl.2020.09.011. PMID: 33223083

Recent clinical studies

Etiology

Carrera J-P, Araúz D, Rojas A, Cardozo F, Stittleburg V, Morales Claro I, Galue J, Lezcano-Coba C, Romero Rebello Moreira F, -Rivera LF, Chen-Germán M, Moreno B, Capitan-Barrios Z, López-Vergès S, Pascale JM, Sabino EC, Valderrama A, Hanley KA, Donnelly CA, Vasilakis N, Faria NR, Waggoner JJ
J Clin Microbiol 2023 Dec 19;61(12):e0015223. Epub 2023 Nov 20 doi: 10.1128/jcm.00152-23. PMID: 37982611Free PMC Article
Hill V, Koch RT, Bialosuknia SM, Ngo K, Zink SD, Koetzner CA, Maffei JG, Dupuis AP, Backenson PB, Oliver J, Bransfield AB, Misencik MJ, Petruff TA, Shepard JJ, Warren JL, Gill MS, Baele G, Vogels CBF, Gallagher G, Burns P, Hentoff A, Smole S, Brown C, Osborne M, Kramer LD, Armstrong PM, Ciota AT, Grubaugh ND
Curr Biol 2023 Jun 19;33(12):2515-2527.e6. Epub 2023 Jun 8 doi: 10.1016/j.cub.2023.05.047. PMID: 37295427Free PMC Article
Kilpatrick AM, Pape WJ
Am J Epidemiol 2013 Sep 1;178(5):829-35. Epub 2013 Jul 3 doi: 10.1093/aje/kwt046. PMID: 23825164Free PMC Article
Johnson AJ, Martin DA, Karabatsos N, Roehrig JT
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Med Biol 1975 Oct;53(5):271-8. PMID: 1207183

Diagnosis

Starolis MW, Perez O, Powell EA
J Clin Virol 2020 Nov;132:104651. Epub 2020 Sep 30 doi: 10.1016/j.jcv.2020.104651. PMID: 33035733
Berlin D, Gilani AI, Grewal AK, Fowkes M
Pract Neurol 2017 Oct;17(5):387-391. Epub 2017 Jul 28 doi: 10.1136/practneurol-2017-001659. PMID: 28754695
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Clin Vaccine Immunol 2010 Jan;17(1):56-61. Epub 2009 Nov 18 doi: 10.1128/CVI.00291-09. PMID: 19923570Free PMC Article
Chiodini J
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Tsai TF
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Therapy

Cao X, Yang D, Parvathareddy J, Chu YK, Kim EJ, Fitz-Henley JN, Li X, Lukka PB, Parmar KR, Temrikar ZH, Dhole P, Adcock RS, Gabbard J, Bansal S, Lee J, Zalduondo L, Hayes E, Stabenow J, Meibohm B, Fitzpatrick EA, Bailey K, Campos RK, Julander JG, Rossi SL, Chung D, Jonsson CB, Golden JE
Sci Transl Med 2023 Apr 12;15(691):eabl9344. doi: 10.1126/scitranslmed.abl9344. PMID: 37043558
Panny L, Akrhymuk I, Bracci N, Woodson C, Flor R, Elliott I, Zhou W, Narayanan A, Campbell C, Kehn-Hall K
Antiviral Res 2023 Apr;212:105560. Epub 2023 Feb 22 doi: 10.1016/j.antiviral.2023.105560. PMID: 36822370
Wilcox DR, Collens SI, Solomon IH, Mateen FJ, Mukerji SS
Neurol Neuroimmunol Neuroinflamm 2021 Jan;8(1) Epub 2020 Nov 10 doi: 10.1212/NXI.0000000000000917. PMID: 33172962Free PMC Article
Williamson LE, Gilliland T Jr, Yadav PK, Binshtein E, Bombardi R, Kose N, Nargi RS, Sutton RE, Durie CL, Armstrong E, Carnahan RH, Walker LM, Kim AS, Fox JM, Diamond MS, Ohi MD, Klimstra WB, Crowe JE Jr
Cell 2020 Dec 23;183(7):1884-1900.e23. Epub 2020 Dec 9 doi: 10.1016/j.cell.2020.11.011. PMID: 33301709Free PMC Article
Yu YA, Bolton M
Clin Pediatr (Phila) 2019 Feb;58(2):245-246. Epub 2018 Oct 15 doi: 10.1177/0009922818806842. PMID: 30318912

Prognosis

Baxter VK, Heise MT
Mamm Genome 2018 Aug;29(7-8):408-424. Epub 2018 Aug 27 doi: 10.1007/s00335-018-9776-1. PMID: 30151711Free PMC Article
Berlin D, Gilani AI, Grewal AK, Fowkes M
Pract Neurol 2017 Oct;17(5):387-391. Epub 2017 Jul 28 doi: 10.1136/practneurol-2017-001659. PMID: 28754695
Kilpatrick AM, Pape WJ
Am J Epidemiol 2013 Sep 1;178(5):829-35. Epub 2013 Jul 3 doi: 10.1093/aje/kwt046. PMID: 23825164Free PMC Article
Villari P, Spielman A, Komar N, McDowell M, Timperi RJ
Am J Trop Med Hyg 1995 Jan;52(1):8-13. doi: 10.4269/ajtmh.1995.52.8. PMID: 7856830
Srihongse S, Grayson MA, Morris CD, Deibel R, Duncan CS
Am J Trop Med Hyg 1978 Nov;27(6):1240-5. doi: 10.4269/ajtmh.1978.27.1240. PMID: 31803

Clinical prediction guides

Hill V, Koch RT, Bialosuknia SM, Ngo K, Zink SD, Koetzner CA, Maffei JG, Dupuis AP, Backenson PB, Oliver J, Bransfield AB, Misencik MJ, Petruff TA, Shepard JJ, Warren JL, Gill MS, Baele G, Vogels CBF, Gallagher G, Burns P, Hentoff A, Smole S, Brown C, Osborne M, Kramer LD, Armstrong PM, Ciota AT, Grubaugh ND
Curr Biol 2023 Jun 19;33(12):2515-2527.e6. Epub 2023 Jun 8 doi: 10.1016/j.cub.2023.05.047. PMID: 37295427Free PMC Article
Cao X, Yang D, Parvathareddy J, Chu YK, Kim EJ, Fitz-Henley JN, Li X, Lukka PB, Parmar KR, Temrikar ZH, Dhole P, Adcock RS, Gabbard J, Bansal S, Lee J, Zalduondo L, Hayes E, Stabenow J, Meibohm B, Fitzpatrick EA, Bailey K, Campos RK, Julander JG, Rossi SL, Chung D, Jonsson CB, Golden JE
Sci Transl Med 2023 Apr 12;15(691):eabl9344. doi: 10.1126/scitranslmed.abl9344. PMID: 37043558
Wilcox DR, Collens SI, Solomon IH, Mateen FJ, Mukerji SS
Neurol Neuroimmunol Neuroinflamm 2021 Jan;8(1) Epub 2020 Nov 10 doi: 10.1212/NXI.0000000000000917. PMID: 33172962Free PMC Article
Kilpatrick AM, Pape WJ
Am J Epidemiol 2013 Sep 1;178(5):829-35. Epub 2013 Jul 3 doi: 10.1093/aje/kwt046. PMID: 23825164Free PMC Article
Schlesinger JJ, Brandriss MW
J Med Virol 1981;8(2):103-17. doi: 10.1002/jmv.1890080204. PMID: 7299376

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