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Western equine encephalitis(WEE)

MedGen UID:
57778
Concept ID:
C0153064
Disease or Syndrome
Synonyms: WEE; Western equine encephalomyelitis
SNOMED CT: Encephalitis, Western equine (47523006); WEE - western equine encephalitis (47523006); Western equine encephalitis (47523006); Western equine encephalomyelitis (47523006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019380
Orphanet: ORPHA83593

Definition

An acute arboviral infection caused by an <i>alphavirus</i> of the <i>Togaviridae</i> family transmitted by an infected mosquito, that more frequently affects children and that is characterized by the presence of mild flulike symptoms (fever, chills, headache, nausea, vomiting, and anorexia) but that can progress to weakness, altered mental status, photophobia, mental confusion, seizures, somnolence, coma and/or even death. The disease can leave neurological sequelae, mainly in infants and children, such as seizures, spasticity or behavioral disorders. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWestern equine encephalitis

Professional guidelines

PubMed

KOKERNOT RH, SHINEFIELD HR, LONGSHORE WA Jr
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Recent clinical studies

Etiology

Li W, Plante JA, Lin C, Basu H, Plung JS, Fan X, Boeckers JM, Oros J, Buck TK, Anekal PV, Hanson WA, Varnum H, Wells A, Mann CJ, Tjang LV, Yang P, Reyna RA, Mitchell BM, Shinde DP, Walker JL, Choi SY, Brusic V, Llopis PM, Weaver SC, Umemori H, Chiu IM, Plante KS, Abraham J
Nature 2024 Aug;632(8025):614-621. Epub 2024 Jul 24 doi: 10.1038/s41586-024-07740-2. PMID: 39048821Free PMC Article
Zimmerman O, Zimmerman MI, Raju S, Nelson CA, Errico JM, Madden EA, Holmes AC, Hassan AO, VanBlargan LA, Kim AS, Adams LJ, Basore K, Whitener BM, Palakurty S, Davis-Adams HG, Sun C, Gilliland T Jr, Earnest JT, Ma H, Ebel GD, Zmasek C, Scheuermann RH, Klimstra WB, Fremont DH, Diamond MS
Cell 2023 Oct 26;186(22):4818-4833.e25. Epub 2023 Oct 6 doi: 10.1016/j.cell.2023.09.007. PMID: 37804831Free PMC Article
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Methods Mol Biol 2011;665:17-38. doi: 10.1007/978-1-60761-817-1_2. PMID: 21116793

Diagnosis

Lello LS, Miilimäe A, Cherkashchenko L, Omler A, Skilton R, Ireland R, Ulaeto D, Merits A
J Virol 2023 Jan 31;97(1):e0136822. Epub 2022 Dec 19 doi: 10.1128/jvi.01368-22. PMID: 36533950Free PMC Article
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PLoS One 2016;11(1):e0147962. Epub 2016 Jan 25 doi: 10.1371/journal.pone.0147962. PMID: 26807734Free PMC Article
Powers AM, Roehrig JT
Methods Mol Biol 2011;665:17-38. doi: 10.1007/978-1-60761-817-1_2. PMID: 21116793
Calisher CH
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J Iowa Med Soc 1976 Aug;66(8):333-4. PMID: 956673

Therapy

Keshtkar-Jahromi M, Reisler RB, Haller JM, Clizbe DP, Rivard RG, Cardile AP, Pierson BC, Norris S, Saunders D, Pittman PR
Front Immunol 2020;11:555464. Epub 2020 Nov 9 doi: 10.3389/fimmu.2020.555464. PMID: 33240257Free PMC Article
Carey BD, Bakovic A, Callahan V, Narayanan A, Kehn-Hall K
Antiviral Res 2019 Mar;163:125-139. Epub 2019 Jan 26 doi: 10.1016/j.antiviral.2019.01.015. PMID: 30695702
Phillips AT, Schountz T, Toth AM, Rico AB, Jarvis DL, Powers AM, Olson KE
J Virol 2014 Feb;88(3):1771-80. Epub 2013 Nov 20 doi: 10.1128/JVI.02297-13. PMID: 24257615Free PMC Article
Furuta Y, Gowen BB, Takahashi K, Shiraki K, Smee DF, Barnard DL
Antiviral Res 2013 Nov;100(2):446-54. Epub 2013 Sep 29 doi: 10.1016/j.antiviral.2013.09.015. PMID: 24084488Free PMC Article
Lim SP, Wang QY, Noble CG, Chen YL, Dong H, Zou B, Yokokawa F, Nilar S, Smith P, Beer D, Lescar J, Shi PY
Antiviral Res 2013 Nov;100(2):500-19. Epub 2013 Sep 27 doi: 10.1016/j.antiviral.2013.09.013. PMID: 24076358

Prognosis

Baxter VK, Heise MT
Mamm Genome 2018 Aug;29(7-8):408-424. Epub 2018 Aug 27 doi: 10.1007/s00335-018-9776-1. PMID: 30151711Free PMC Article
Reisler RB, Gibbs PH, Danner DK, Boudreau EF
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Sellers RF, Maarouf AR
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Clinical prediction guides

Zhang R, Tan P, Feng L, Li R, Yang J, Zhang R, Li J
Virus Res 2021 Dec;306:198598. Epub 2021 Oct 13 doi: 10.1016/j.virusres.2021.198598. PMID: 34653568
Bergren NA, Haller S, Rossi SL, Seymour RL, Huang J, Miller AL, Bowen RA, Hartman DA, Brault AC, Weaver SC
PLoS Pathog 2020 Feb;16(2):e1008102. Epub 2020 Feb 6 doi: 10.1371/journal.ppat.1008102. PMID: 32027727Free PMC Article
Phillips AT, Rico AB, Stauft CB, Hammond SL, Aboellail TA, Tjalkens RB, Olson KE
J Virol 2016 Jun 15;90(12):5785-96. Epub 2016 May 27 doi: 10.1128/JVI.03219-15. PMID: 27053560Free PMC Article
Mossel EC, Ledermann JP, Phillips AT, Borland EM, Powers AM, Olson KE
PLoS One 2013;8(3):e60427. Epub 2013 Mar 27 doi: 10.1371/journal.pone.0060427. PMID: 23544138Free PMC Article
Sellers RF, Maarouf AR
Epidemiol Infect 1988 Dec;101(3):511-35. doi: 10.1017/s095026880002940x. PMID: 2905669Free PMC Article

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