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Neoplasms, Bone Tissue

MedGen UID:
104905
•Concept ID:
C0206639
•
Neoplastic Process
Synonyms: Bone Tissue Neoplasm; Bone Tissue Neoplasms; Bony Tissue Neoplasm; Bony Tissue Neoplasms; Neoplasm, Bone Tissue; Neoplasm, Bony Tissue; Neoplasms, Bony Tissue; Tissue Neoplasm, Bone; Tissue Neoplasm, Bony; Tissue Neoplasms, Bone; Tissue Neoplasms, Bony

Definition

Neoplasms composed of bony tissue, whether normal or of a soft tissue which has become ossified. The concept does not refer to neoplasms located in bones. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasms, Bone Tissue

Professional guidelines

PubMed

Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Gronchi A, Miah AB, Dei Tos AP, Abecassis N, Bajpai J, Bauer S, Biagini R, Bielack S, Blay JY, Bolle S, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brennan B, Brodowicz T, Buonadonna A, De Álava E, Del Muro XG, Dufresne A, Eriksson M, Fagioli F, Fedenko A, Ferraresi V, Ferrari A, Frezza AM, Gasperoni S, Gelderblom H, Gouin F, Grignani G, Haas R, Hassan AB, Hecker-Nolting S, Hindi N, Hohenberger P, Joensuu H, Jones RL, Jungels C, Jutte P, Kager L, Kasper B, Kawai A, Kopeckova K, Krákorová DA, Le Cesne A, Le Grange F, Legius E, Leithner A, Lopez-Pousa A, Martin-Broto J, Merimsky O, Messiou C, Mir O, Montemurro M, Morland B, Morosi C, Palmerini E, Pantaleo MA, Piana R, Piperno-Neumann S, Reichardt P, Rutkowski P, Safwat AA, Sangalli C, Sbaraglia M, Scheipl S, Schöffski P, Sleijfer S, Strauss D, Strauss S, Sundby Hall K, Trama A, Unk M, van de Sande MAJ, van der Graaf WTA, van Houdt WJ, Frebourg T, Casali PG, Stacchiotti S; ESMO Guidelines Committee, EURACAN and GENTURIS. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Nov;32(11):1348-1365. Epub 2021 Jul 22 doi: 10.1016/j.annonc.2021.07.006. PMID: 34303806
Bone Cancer: Diagnosis and Treatment Principles.
Ferguson JL, Turner SP
Am Fam Physician 2018 Aug 15;98(4):205-213. PMID: 30215968
The Diagnosis and Treatment of Prostate Cancer: A Review.
Litwin MS, Tan HJ
JAMA 2017 Jun 27;317(24):2532-2542. doi: 10.1001/jama.2017.7248. PMID: 28655021

Recent clinical studies

Etiology

Sclerostin expression in skeletal sarcomas.
Shen J, Meyers CA, Shrestha S, Singh A, LaChaud G, Nguyen V, Asatrian G, Federman N, Bernthal N, Eilber FC, Dry SM, Ting K, Soo C, James AW
Hum Pathol 2016 Dec;58:24-34. Epub 2016 Aug 3 doi: 10.1016/j.humpath.2016.07.016. PMID: 27498059Free PMC Article
Predicting blood loss and transfusion requirement in patients undergoing surgery for musculoskeletal tumors.
Thompson PA, May D, Choong PF, Tacey M, Liew D, Cole-Sinclair MF
Transfusion 2014 Jun;54(6):1469-77. Epub 2014 Jan 12 doi: 10.1111/trf.12532. PMID: 24411009
Spinal tumors in children.
Binning M, Klimo P Jr, Gluf W, Goumnerova L
Neurosurg Clin N Am 2007 Oct;18(4):631-58. doi: 10.1016/j.nec.2007.07.001. PMID: 17991588
Heterotopic ossification: review of histologic findings and tissue distribution in a 10-year experience.
Liu K, Tripp S, Layfield LJ
Pathol Res Pract 2007;203(9):633-40. doi: 10.1016/j.prp.2007.05.014. PMID: 17728073
Radiologic appearance of primary jaw lesions in children.
Gupta M, Kaste SC, Hopkins KP
Pediatr Radiol 2002 Mar;32(3):153-68. doi: 10.1007/s00247-001-0633-z. PMID: 12164347

Diagnosis

Benign bone tumors.
Steffner R
Cancer Treat Res 2014;162:31-63. doi: 10.1007/978-3-319-07323-1_3. PMID: 25070230
Primary tumors of the spine.
Orguc S, Arkun R
Semin Musculoskelet Radiol 2014 Jul;18(3):280-99. Epub 2014 Jun 4 doi: 10.1055/s-0034-1375570. PMID: 24896744
Benign bone tumors.
Motamedi K, Seeger LL
Radiol Clin North Am 2011 Nov;49(6):1115-34, v. doi: 10.1016/j.rcl.2011.07.002. PMID: 22024291
Tumors of the spine in children.
Rossi A, Gandolfo C, Morana G, Tortori-Donati P
Neuroimaging Clin N Am 2007 Feb;17(1):17-35. doi: 10.1016/j.nic.2006.11.004. PMID: 17493537
Osteosarcoma (osteogenic sarcoma).
Picci P
Orphanet J Rare Dis 2007 Jan 23;2:6. doi: 10.1186/1750-1172-2-6. PMID: 17244349Free PMC Article

Therapy

NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma.
Peterse EFP, van den Akker BEWM, Niessen B, Oosting J, Suijker J, de Jong Y, Danen EHJ, Cleton-Jansen AM, Bovée JVMG
Mol Cancer Res 2017 Dec;15(12):1714-1721. Epub 2017 Aug 31 doi: 10.1158/1541-7786.MCR-17-0293. PMID: 28860121
Predicting blood loss and transfusion requirement in patients undergoing surgery for musculoskeletal tumors.
Thompson PA, May D, Choong PF, Tacey M, Liew D, Cole-Sinclair MF
Transfusion 2014 Jun;54(6):1469-77. Epub 2014 Jan 12 doi: 10.1111/trf.12532. PMID: 24411009
Multidisciplinary management of primary tumors of the vertebral column.
Hsu W, Kosztowski TA, Zaidi HA, Dorsi M, Gokaslan ZL, Wolinsky JP
Curr Treat Options Oncol 2009 Apr;10(1-2):107-25. Epub 2009 Jun 23 doi: 10.1007/s11864-009-0102-8. PMID: 19548089
Tumors of the spine in children.
Rossi A, Gandolfo C, Morana G, Tortori-Donati P
Neuroimaging Clin N Am 2007 Feb;17(1):17-35. doi: 10.1016/j.nic.2006.11.004. PMID: 17493537
Characteristics and outcome of infections associated with tumor endoprostheses.
Hardes J, Gebert C, Schwappach A, Ahrens H, Streitburger A, Winkelmann W, Gosheger G
Arch Orthop Trauma Surg 2006 Jul;126(5):289-96. Epub 2006 Apr 21 doi: 10.1007/s00402-005-0009-1. PMID: 16628430

Prognosis

Predicting blood loss and transfusion requirement in patients undergoing surgery for musculoskeletal tumors.
Thompson PA, May D, Choong PF, Tacey M, Liew D, Cole-Sinclair MF
Transfusion 2014 Jun;54(6):1469-77. Epub 2014 Jan 12 doi: 10.1111/trf.12532. PMID: 24411009
Primary bone tumours and tumour-like lesions in children in Zaria, Nigeria.
Mohammed A, Sani MA, Hezekiah IA, Enoch AA
Afr J Paediatr Surg 2010 Jan-Apr;7(1):16-8. doi: 10.4103/0189-6725.59353. PMID: 20098003
Proliferation and apoptosis of tumour cells before and after neoadjuvant therapy for high-grade extremity sarcomas: divergent associations with tumour response and prognosis.
Matsubara T, Eimoto T, Okabe M, Miyabe S, Fujiyoshi Y, Matsushita Y, Mizutani J, Yamada S, Otsuka T
Histopathology 2008 May;52(6):706-16. Epub 2008 Apr 2 doi: 10.1111/j.1365-2559.2008.03015.x. PMID: 18393971
Osteosarcoma (osteogenic sarcoma).
Picci P
Orphanet J Rare Dis 2007 Jan 23;2:6. doi: 10.1186/1750-1172-2-6. PMID: 17244349Free PMC Article
Characteristics and outcome of infections associated with tumor endoprostheses.
Hardes J, Gebert C, Schwappach A, Ahrens H, Streitburger A, Winkelmann W, Gosheger G
Arch Orthop Trauma Surg 2006 Jul;126(5):289-96. Epub 2006 Apr 21 doi: 10.1007/s00402-005-0009-1. PMID: 16628430

Clinical prediction guides

NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma.
Peterse EFP, van den Akker BEWM, Niessen B, Oosting J, Suijker J, de Jong Y, Danen EHJ, Cleton-Jansen AM, Bovée JVMG
Mol Cancer Res 2017 Dec;15(12):1714-1721. Epub 2017 Aug 31 doi: 10.1158/1541-7786.MCR-17-0293. PMID: 28860121
Sclerostin expression in skeletal sarcomas.
Shen J, Meyers CA, Shrestha S, Singh A, LaChaud G, Nguyen V, Asatrian G, Federman N, Bernthal N, Eilber FC, Dry SM, Ting K, Soo C, James AW
Hum Pathol 2016 Dec;58:24-34. Epub 2016 Aug 3 doi: 10.1016/j.humpath.2016.07.016. PMID: 27498059Free PMC Article
Clinical long-term outcome, technical success, and cost analysis of radiofrequency ablation for the treatment of osteoblastomas and spinal osteoid osteomas in comparison to open surgical resection.
Weber MA, Sprengel SD, Omlor GW, Lehner B, Wiedenhöfer B, Kauczor HU, Rehnitz C
Skeletal Radiol 2015 Jul;44(7):981-93. Epub 2015 Apr 25 doi: 10.1007/s00256-015-2139-z. PMID: 25910709
Lactoferrin immuno-expression in human normal and neoplastic bone tissue.
Ieni A, Barresi V, Grosso M, Rosa MA, Tuccari G
J Bone Miner Metab 2009;27(3):364-71. Epub 2009 Feb 26 doi: 10.1007/s00774-009-0044-z. PMID: 19240970
Heterotopic ossification: review of histologic findings and tissue distribution in a 10-year experience.
Liu K, Tripp S, Layfield LJ
Pathol Res Pract 2007;203(9):633-40. doi: 10.1016/j.prp.2007.05.014. PMID: 17728073

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