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Osteoblastoma

MedGen UID:
18212
•Concept ID:
C0029417
•
Neoplastic Process
Synonyms: Giant Osteoid Osteoma; Giant Osteoid Osteomas; Osteoblastomas; Osteoid Osteoma, Giant; Osteoid Osteomas, Giant; Osteoma, Giant Osteoid; Osteomas, Giant Osteoid
SNOMED CT: Osteoblastoma (55333008); Giant osteoid osteoma (55333008)
 
HPO: HP:0011846
Monarch Initiative: MONDO:0018936
Orphanet: ORPHA58040

Definition

A benign, painful, tumor of bone characterized by the formation of osteoid tissue, primitive bone and calcified tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteoblastoma
Follow this link to review classifications for Osteoblastoma in Orphanet.

Professional guidelines

PubMed

Spinal Tumor Ablation: Indications, Techniques, and Clinical Management.
Cazzato RL, Auloge P, De Marini P, Boatta E, Koch G, Dalili D, Rao PP, Garnon J, Gangi A
Tech Vasc Interv Radiol 2020 Jun;23(2):100677. Epub 2020 May 27 doi: 10.1016/j.tvir.2020.100677. PMID: 32591193
Diagnostic and Management Options of Osteoblastoma in the Spine.
Wu M, Xu K, Xie Y, Yan F, Deng Z, Lei J, Cai L
Med Sci Monit 2019 Feb 20;25:1362-1372. doi: 10.12659/MSM.913666. PMID: 30785872Free PMC Article
Management Strategy of Osteoblastomas Localized in the Occipitocervical Junction.
Czigléczki G, Nagy Z, Papp Z, Padányi C, Banczerowski P
World Neurosurg 2017 Jan;97:505-512. Epub 2016 Oct 15 doi: 10.1016/j.wneu.2016.10.040. PMID: 27756672

Recent clinical studies

Etiology

Bone Tumors: Benign Bone Tumors.
Lam Y
FP Essent 2020 Jun;493:11-21. PMID: 32573182
Diagnostic and Management Options of Osteoblastoma in the Spine.
Wu M, Xu K, Xie Y, Yan F, Deng Z, Lei J, Cai L
Med Sci Monit 2019 Feb 20;25:1362-1372. doi: 10.12659/MSM.913666. PMID: 30785872Free PMC Article
Fusions at the craniovertebral junction.
Ahmed R, Traynelis VC, Menezes AH
Childs Nerv Syst 2008 Oct;24(10):1209-24. Epub 2008 Apr 4 doi: 10.1007/s00381-008-0607-7. PMID: 18389260
Spinal biomodeling.
D'Urso PS, Askin G, Earwaker JS, Merry GS, Thompson RG, Barker TM, Effeney DJ
Spine (Phila Pa 1976) 1999 Jun 15;24(12):1247-51. doi: 10.1097/00007632-199906150-00013. PMID: 10382253
Osteoid osteoma--osteoblastoma.
De Souza Diaz L, Frost HM
Cancer 1974 Apr;33(4):1075-81. doi: 10.1002/1097-0142(197404)33:4<1075::aid-cncr2820330427>3.0.co;2-4. PMID: 4819213

Diagnosis

New kids on the block: FOS and FOSB gene.
Cordier F, Creytens D
J Clin Pathol 2023 Nov;76(11):721-726. Epub 2023 Aug 8 doi: 10.1136/jcp-2023-208931. PMID: 37553246
Benign Bone-Forming Tumors.
Amary F, Flanagan AM, O'Donnell P
Surg Pathol Clin 2021 Dec;14(4):549-565. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.002. PMID: 34742480
Osteoid Tumors of Bone.
Amini B, Valenzuela RF, Bird JE, Haygood TM
Semin Ultrasound CT MR 2021 Apr;42(2):134-149. Epub 2020 Aug 29 doi: 10.1053/j.sult.2020.08.020. PMID: 33814101
Bone-Forming Tumors.
Zhang Y, Rosenberg AE
Surg Pathol Clin 2017 Sep;10(3):513-535. Epub 2017 Jun 29 doi: 10.1016/j.path.2017.04.006. PMID: 28797500
Osteogenic tumors of bone.
Green JT, Mills AM
Semin Diagn Pathol 2014 Jan;31(1):21-9. Epub 2014 Jan 5 doi: 10.1053/j.semdp.2014.01.001. PMID: 24680179

Therapy

Aneurysmal bone cyst and osteoblastoma after neoadjuvant denosumab: histologic spectrum and potential diagnostic pitfalls.
Hung YP, Bredella MA, Lobmaier IVK, Lozano-Calderón SA, Rosenberg AE, Nielsen GP
APMIS 2022 Apr;130(4):206-214. Epub 2022 Feb 18 doi: 10.1111/apm.13211. PMID: 35114728
Spinal Tumor Ablation: Indications, Techniques, and Clinical Management.
Cazzato RL, Auloge P, De Marini P, Boatta E, Koch G, Dalili D, Rao PP, Garnon J, Gangi A
Tech Vasc Interv Radiol 2020 Jun;23(2):100677. Epub 2020 May 27 doi: 10.1016/j.tvir.2020.100677. PMID: 32591193
Osteoid osteoma and osteoblastoma.
Atesok KI, Alman BA, Schemitsch EH, Peyser A, Mankin H
J Am Acad Orthop Surg 2011 Nov;19(11):678-89. doi: 10.5435/00124635-201111000-00004. PMID: 22052644
Fusions at the craniovertebral junction.
Ahmed R, Traynelis VC, Menezes AH
Childs Nerv Syst 2008 Oct;24(10):1209-24. Epub 2008 Apr 4 doi: 10.1007/s00381-008-0607-7. PMID: 18389260
Spinal biomodeling.
D'Urso PS, Askin G, Earwaker JS, Merry GS, Thompson RG, Barker TM, Effeney DJ
Spine (Phila Pa 1976) 1999 Jun 15;24(12):1247-51. doi: 10.1097/00007632-199906150-00013. PMID: 10382253

Prognosis

Benign tumors of the spine.
Thakur NA, Daniels AH, Schiller J, Valdes MA, Czerwein JK, Schiller A, Esmende S, Terek RM
J Am Acad Orthop Surg 2012 Nov;20(11):715-24. doi: 10.5435/JAAOS-20-11-715. PMID: 23118137
Osteoid osteoma and osteoblastoma.
Atesok KI, Alman BA, Schemitsch EH, Peyser A, Mankin H
J Am Acad Orthop Surg 2011 Nov;19(11):678-89. doi: 10.5435/00124635-201111000-00004. PMID: 22052644
Benign bone tumors--recent developments.
Garcia RA, Inwards CY, Unni KK
Semin Diagn Pathol 2011 Feb;28(1):73-85. doi: 10.1053/j.semdp.2011.02.013. PMID: 21675379
Malignant osteoblastoma.
Schajowicz F, Lemos C
J Bone Joint Surg Br 1976 May;58(2):202-11. doi: 10.1302/0301-620X.58B2.932083. PMID: 932083
Osteoid osteoma--osteoblastoma.
De Souza Diaz L, Frost HM
Cancer 1974 Apr;33(4):1075-81. doi: 10.1002/1097-0142(197404)33:4<1075::aid-cncr2820330427>3.0.co;2-4. PMID: 4819213

Clinical prediction guides

New kids on the block: FOS and FOSB gene.
Cordier F, Creytens D
J Clin Pathol 2023 Nov;76(11):721-726. Epub 2023 Aug 8 doi: 10.1136/jcp-2023-208931. PMID: 37553246
FOS Rearrangement and Expression in Cementoblastoma.
Lam SW, Cleven AHG, Briaire-de Bruijn IH, Schreuder WH, Kroon HM, Savci-Heijink DC, Suurmeijer AJH, Szuhai K, Bovée JVMG, Baumhoer D
Am J Surg Pathol 2021 May 1;45(5):690-693. doi: 10.1097/PAS.0000000000001695. PMID: 33653978
Diagnostic and Management Options of Osteoblastoma in the Spine.
Wu M, Xu K, Xie Y, Yan F, Deng Z, Lei J, Cai L
Med Sci Monit 2019 Feb 20;25:1362-1372. doi: 10.12659/MSM.913666. PMID: 30785872Free PMC Article
Osteoblastoma of the elbow: analysis of 13 patients and literature review.
Angelini A, Varela-Osorio AF, Trovarelli G, Berizzi A, Zanotti G, Ruggieri P
Eur J Orthop Surg Traumatol 2017 Aug;27(6):787-795. Epub 2017 Jun 20 doi: 10.1007/s00590-017-1997-6. PMID: 28634923
Benign tumors of the spine.
Thakur NA, Daniels AH, Schiller J, Valdes MA, Czerwein JK, Schiller A, Esmende S, Terek RM
J Am Acad Orthop Surg 2012 Nov;20(11):715-24. doi: 10.5435/JAAOS-20-11-715. PMID: 23118137

Recent systematic reviews

Pediatric cranial osteoblastoma: Technical note of surgical treatment and review of the literature.
Garvayo M, Cossu G, Broome M, Maeder P, Renella R, Maduri R, Daniel RT, Messerer M
Neurochirurgie 2021 Jul;67(4):383-390. Epub 2020 Oct 10 doi: 10.1016/j.neuchi.2020.05.010. PMID: 33049284
Pediatric Benign Paranasal Sinus Osteoneogenic Tumors: A Case Series and Systematic Review of Outcomes, Techniques, and a Multiportal Approach.
Badran KW, Suh JD, Namiri N, Wrobel B, Ference EH
Am J Rhinol Allergy 2018 Nov;32(6):465-472. Epub 2018 Aug 22 doi: 10.1177/1945892418793475. PMID: 30132339
Osteoid osteoma of the temporal bone manifesting as first bite syndrome and a meta-analysis combined with osteoblastoma.
Hidaka H, Yamauchi D, Fujishima F, Watanabe M, Kato Y, Nomura K, Watanabe K, Kawase T, Katori Y
Eur Arch Otorhinolaryngol 2017 Feb;274(2):607-616. Epub 2016 Apr 22 doi: 10.1007/s00405-016-4050-1. PMID: 27106094
Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor.
Harrop JS, Schmidt MH, Boriani S, Shaffrey CI
Spine (Phila Pa 1976) 2009 Oct 15;34(22 Suppl):S39-47. doi: 10.1097/BRS.0b013e3181ba0024. PMID: 19829276
Osteoblastoma of the mandible: systematic review of the literature and report of a case.
Alvares Capelozza AL, Gião Dezotti MS, Casati Alvares L, Negrão Fleury R, Sant'Ana E
Dentomaxillofac Radiol 2005 Jan;34(1):1-8. doi: 10.1259/dmfr/24385194. PMID: 15709098

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