U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myocardial ischemia

MedGen UID:
101801
Concept ID:
C0151744
Disease or Syndrome
Synonyms: Disease, Ischemic Heart; Diseases, Ischemic Heart; Heart Disease, Ischemic; Heart Diseases, Ischemic; Ischemia, Myocardial; Ischemias, Myocardial; Ischemic Heart Disease; Ischemic Heart Diseases; Myocardial Ischemia; Myocardial Ischemias
SNOMED CT: Ischemic heart disease (414545008); Myocardial ischemia (414795007); IHD - Ischemic heart disease (414545008); Cardiac ischemia (414795007)
 
Monarch Initiative: MONDO:0024644

Definition

A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries, to obstruction by a thrombus, or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction). [from NCI]

Professional guidelines

PubMed

Virani SS, Newby LK, Arnold SV, Bittner V, Brewer LC, Demeter SH, Dixon DL, Fearon WF, Hess B, Johnson HM, Kazi DS, Kolte D, Kumbhani DJ, LoFaso J, Mahtta D, Mark DB, Minissian M, Navar AM, Patel AR, Piano MR, Rodriguez F, Talbot AW, Taqueti VR, Thomas RJ, van Diepen S, Wiggins B, Williams MS; Peer Review Committee Members
Circulation 2023 Aug 29;148(9):e9-e119. Epub 2023 Jul 20 doi: 10.1161/CIR.0000000000001168. PMID: 37471501
Gulati M, Levy PD, Mukherjee D, Amsterdam E, Bhatt DL, Birtcher KK, Blankstein R, Boyd J, Bullock-Palmer RP, Conejo T, Diercks DB, Gentile F, Greenwood JP, Hess EP, Hollenberg SM, Jaber WA, Jneid H, Joglar JA, Morrow DA, O'Connor RE, Ross MA, Shaw LJ
Circulation 2021 Nov 30;144(22):e368-e454. Epub 2021 Oct 28 doi: 10.1161/CIR.0000000000001029. PMID: 34709879
Joshi PH, de Lemos JA
JAMA 2021 May 4;325(17):1765-1778. doi: 10.1001/jama.2021.1527. PMID: 33944871

Recent clinical studies

Etiology

Zhu C, Miao L, Wei K, Shi D, Gao J
Microvasc Res 2024 May;153:104652. Epub 2024 Jan 9 doi: 10.1016/j.mvr.2024.104652. PMID: 38211894
Katz D, Gavin MC
Ann Intern Med 2019 Aug 6;171(3):ITC17-ITC32. doi: 10.7326/AITC201908060. PMID: 31382288
Torres-Yaghi Y, Salerian J, Dougherty C
Curr Pain Headache Rep 2015 Apr;19(4):14. doi: 10.1007/s11916-015-0481-4. PMID: 25819974
Le HC, Thys DM
Semin Cardiothorac Vasc Anesth 2006 Mar;10(1):73-7. doi: 10.1177/108925320601000113. PMID: 16703238
Picano E
Expert Rev Cardiovasc Ther 2004 Jan;2(1):77-88. doi: 10.1586/14779072.2.1.77. PMID: 15038415

Diagnosis

Varga-Szemes A, Suranyi P
Eur Radiol Exp 2021 Mar 25;5(1):13. doi: 10.1186/s41747-021-00211-7. PMID: 33763736Free PMC Article
González LS, Izquierdo DA, Davidovich RM
Int Anesthesiol Clin 2021 Winter;59(1):45-52. doi: 10.1097/AIA.0000000000000302. PMID: 33122545
Katz D, Gavin MC
Ann Intern Med 2019 Aug 6;171(3):ITC17-ITC32. doi: 10.7326/AITC201908060. PMID: 31382288
Nikus KC, Birnbaum Y
J Electrocardiol 2009 Jan-Feb;42(1):1-5. Epub 2008 Nov 12 doi: 10.1016/j.jelectrocard.2008.10.003. PMID: 19004454
John AD, Fleisher L
Int Anesthesiol Clin 2004 Winter;42(1):1-12. doi: 10.1097/00004311-200404210-00003. PMID: 14716194

Therapy

Cheng XS, VanWagner LB, Costa SP, Axelrod DA, Bangalore S, Norman SP, Herzog CA, Lentine KL; American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Cardiovascular Radiology and Intervention
Circulation 2022 Nov 22;146(21):e299-e324. Epub 2022 Oct 17 doi: 10.1161/CIR.0000000000001104. PMID: 36252095Free PMC Article
Upadhyaya V, Gowda SN, Porto G, Bavishi CP, Sardar P, Bashir R, Gokceer ME, Chatterjee S
Curr Cardiol Rep 2022 Jun;24(6):653-657. Epub 2022 Mar 30 doi: 10.1007/s11886-022-01684-7. PMID: 35353329
Savarese G, Stolfo D, Sinagra G, Lund LH
Nat Rev Cardiol 2022 Feb;19(2):100-116. Epub 2021 Sep 6 doi: 10.1038/s41569-021-00605-5. PMID: 34489589Free PMC Article
Banerjee M, Reynolds E, Andersson HB, Nallamothu BK
Circ Cardiovasc Qual Outcomes 2019 May;12(5):e004879. doi: 10.1161/CIRCOUTCOMES.118.004879. PMID: 31043064Free PMC Article
ISCHEMIA Trial Research Group, Maron DJ, Hochman JS, O'Brien SM, Reynolds HR, Boden WE, Stone GW, Bangalore S, Spertus JA, Mark DB, Alexander KP, Shaw L, Berger JS, Ferguson TB Jr, Williams DO, Harrington RA, Rosenberg Y
Am Heart J 2018 Jul;201:124-135. Epub 2018 Apr 21 doi: 10.1016/j.ahj.2018.04.011. PMID: 29778671Free PMC Article

Prognosis

Inoue-Choi M, Ramirez Y, Cornelis MC, Berrington de González A, Freedman ND, Loftfield E
Ann Intern Med 2022 Sep;175(9):1201-1211. Epub 2022 Aug 30 doi: 10.7326/M22-0041. PMID: 36037472Free PMC Article
Chaitman BR, Alexander KP, Cyr DD, Berger JS, Reynolds HR, Bangalore S, Boden WE, Lopes RD, Demkow M, Piero Perna G, Riezebos RK, McFalls EO, Banerjee S, Bagai A, Gosselin G, O'Brien SM, Rockhold FW, Waters DD, Thygesen KA, Stone GW, White HD, Maron DJ, Hochman JS; ISCHEMIA Research Group
Circulation 2021 Feb 23;143(8):790-804. Epub 2020 Dec 3 doi: 10.1161/CIRCULATIONAHA.120.047987. PMID: 33267610Free PMC Article
Panza JA, Ellis AM, Al-Khalidi HR, Holly TA, Berman DS, Oh JK, Pohost GM, Sopko G, Chrzanowski L, Mark DB, Kukulski T, Favaloro LE, Maurer G, Farsky PS, Tan RS, Asch FM, Velazquez EJ, Rouleau JL, Lee KL, Bonow RO
N Engl J Med 2019 Aug 22;381(8):739-748. doi: 10.1056/NEJMoa1807365. PMID: 31433921Free PMC Article
Velazquez EJ, Lee KL, Jones RH, Al-Khalidi HR, Hill JA, Panza JA, Michler RE, Bonow RO, Doenst T, Petrie MC, Oh JK, She L, Moore VL, Desvigne-Nickens P, Sopko G, Rouleau JL; STICHES Investigators
N Engl J Med 2016 Apr 21;374(16):1511-20. Epub 2016 Apr 3 doi: 10.1056/NEJMoa1602001. PMID: 27040723Free PMC Article
Ackland GL, Edwards M
Curr Opin Crit Care 2010 Aug;16(4):339-46. doi: 10.1097/MCC.0b013e328339fad5. PMID: 20489608

Clinical prediction guides

Cundari G, Marchitelli L, Pambianchi G, Catapano F, Conia L, Stancanelli G, Catalano C, Galea N
Radiol Med 2024 Mar;129(3):380-400. Epub 2024 Feb 6 doi: 10.1007/s11547-024-01771-5. PMID: 38319493Free PMC Article
Tanabe Y, Kurata A, Matsuda T, Yoshida K, Baruah D, Kido T, Mochizuki T, Rajiah P
Jpn J Radiol 2020 May;38(5):411-433. Epub 2020 Feb 5 doi: 10.1007/s11604-020-00922-8. PMID: 32026226Free PMC Article
Bavishi C, Argulian E, Chatterjee S, Rozanski A
JACC Cardiovasc Imaging 2016 May;9(5):580-9. Epub 2016 Apr 13 doi: 10.1016/j.jcmg.2015.11.023. PMID: 27085440
Wu JC, Bengel FM, Gambhir SS
Radiology 2007 Aug;244(2):337-55. Epub 2007 Jun 25 doi: 10.1148/radiol.2442060136. PMID: 17592037
Glancy DL, Patterson CM
J La State Med Soc 2003 Jan-Feb;155(1):26-35; quiz 35, 63. PMID: 12656272

Recent systematic reviews

Little MP, Azizova TV, Richardson DB, Tapio S, Bernier MO, Kreuzer M, Cucinotta FA, Bazyka D, Chumak V, Ivanov VK, Veiga LHS, Livinski A, Abalo K, Zablotska LB, Einstein AJ, Hamada N
BMJ 2023 Mar 8;380:e072924. doi: 10.1136/bmj-2022-072924. PMID: 36889791Free PMC Article
Dybvik JS, Svendsen M, Aune D
Eur J Nutr 2023 Feb;62(1):51-69. Epub 2022 Aug 27 doi: 10.1007/s00394-022-02942-8. PMID: 36030329Free PMC Article
Fazlollahi A, Zahmatyar M, Noori M, Nejadghaderi SA, Sullman MJM, Shekarriz-Foumani R, Kolahi AA, Singh K, Safiri S
Rev Med Virol 2022 Jul;32(4):e2318. Epub 2021 Dec 17 doi: 10.1002/rmv.2318. PMID: 34921468
Wesselink EM, Kappen TH, Torn HM, Slooter AJC, van Klei WA
Br J Anaesth 2018 Oct;121(4):706-721. Epub 2018 Jun 20 doi: 10.1016/j.bja.2018.04.036. PMID: 30236233
Kyu HH, Bachman VF, Alexander LT, Mumford JE, Afshin A, Estep K, Veerman JL, Delwiche K, Iannarone ML, Moyer ML, Cercy K, Vos T, Murray CJ, Forouzanfar MH
BMJ 2016 Aug 9;354:i3857. doi: 10.1136/bmj.i3857. PMID: 27510511Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...