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Prinzmetal angina

MedGen UID:
295
•Concept ID:
C0002963
•
Disease or Syndrome
Synonyms: Angina Pectoris, Variant; Prinzmetal's variant angina; Variant angina
SNOMED CT: Variant angina (87343002); Coronary artery spasm angina (87343002); Prinzmetal's angina (87343002); Prinzmetal angina (87343002); Variant angina pectoris (87343002)
 
Monarch Initiative: MONDO:0006021

Definition

A variant form of angina pectoris caused by coronary artery vasospasm, usually occurring spontaneously and frequently associated with ST segment elevation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrinzmetal angina

Professional guidelines

PubMed

Vasospastic angina: a review on diagnostic approach and management.
Jenkins K, Pompei G, Ganzorig N, Brown S, Beltrame J, Kunadian V
Ther Adv Cardiovasc Dis 2024 Jan-Dec;18:17539447241230400. doi: 10.1177/17539447241230400. PMID: 38343041Free PMC Article
Pharmacological coronary spasm provocative testing in clinical practice: A French Coronary Atheroma and Interventional Cardiology Group (GACI) position paper.
Picard F, Adjedj J, Collet JP, Van Belle E, Monsegu J, Karsenty B, Dupouy P, Quillot M, Bonnet G, Gautier A, Cayla G, Benamer H
Arch Cardiovasc Dis 2023 Dec;116(12):590-596. Epub 2023 Oct 13 doi: 10.1016/j.acvd.2023.10.002. PMID: 37891058
5-Fluorouracil, capecitabine and vasospasm: a scoping review of pathogenesis, management options and future research considerations.
Teperikidis E, Boulmpou A, Charalampidis P, Tsavousoglou C, Giannakoulas G, Papadopoulos CE, Vassilikos V
Acta Cardiol 2022 Feb;77(1):1-13. Epub 2021 Mar 8 doi: 10.1080/00015385.2021.1873548. PMID: 33683181

Recent clinical studies

Etiology

Vasospastic angina: a review on diagnostic approach and management.
Jenkins K, Pompei G, Ganzorig N, Brown S, Beltrame J, Kunadian V
Ther Adv Cardiovasc Dis 2024 Jan-Dec;18:17539447241230400. doi: 10.1177/17539447241230400. PMID: 38343041Free PMC Article
Pharmacological coronary spasm provocative testing in clinical practice: A French Coronary Atheroma and Interventional Cardiology Group (GACI) position paper.
Picard F, Adjedj J, Collet JP, Van Belle E, Monsegu J, Karsenty B, Dupouy P, Quillot M, Bonnet G, Gautier A, Cayla G, Benamer H
Arch Cardiovasc Dis 2023 Dec;116(12):590-596. Epub 2023 Oct 13 doi: 10.1016/j.acvd.2023.10.002. PMID: 37891058
Spontaneous Multivessel Coronary Spasm During Diagnostic Coronary Angiography.
Damera RR, Ijlal Khan M, Oliynyk V, Javaid A
Tex Heart Inst J 2022 Mar 1;49(2) doi: 10.14503/THIJ-20-7357. PMID: 35377456Free PMC Article
5-Fluorouracil, capecitabine and vasospasm: a scoping review of pathogenesis, management options and future research considerations.
Teperikidis E, Boulmpou A, Charalampidis P, Tsavousoglou C, Giannakoulas G, Papadopoulos CE, Vassilikos V
Acta Cardiol 2022 Feb;77(1):1-13. Epub 2021 Mar 8 doi: 10.1080/00015385.2021.1873548. PMID: 33683181
Acute Myocardial Infarction in Young Individuals.
Gulati R, Behfar A, Narula J, Kanwar A, Lerman A, Cooper L, Singh M
Mayo Clin Proc 2020 Jan;95(1):136-156. doi: 10.1016/j.mayocp.2019.05.001. PMID: 31902409

Diagnosis

Hyperventilation testing in the diagnosis of vasospastic angina: A clinical review and meta-analysis.
Boivin-Proulx LA, Marquis-Gravel G, Rousseau-Saine N, Harel F, Jolicoeur EM, Pelletier-Galarneau M
Eur J Clin Invest 2024 Jun;54(6):e14178. Epub 2024 Feb 13 doi: 10.1111/eci.14178. PMID: 38348627
Vasospastic angina: a review on diagnostic approach and management.
Jenkins K, Pompei G, Ganzorig N, Brown S, Beltrame J, Kunadian V
Ther Adv Cardiovasc Dis 2024 Jan-Dec;18:17539447241230400. doi: 10.1177/17539447241230400. PMID: 38343041Free PMC Article
5-Fluorouracil, capecitabine and vasospasm: a scoping review of pathogenesis, management options and future research considerations.
Teperikidis E, Boulmpou A, Charalampidis P, Tsavousoglou C, Giannakoulas G, Papadopoulos CE, Vassilikos V
Acta Cardiol 2022 Feb;77(1):1-13. Epub 2021 Mar 8 doi: 10.1080/00015385.2021.1873548. PMID: 33683181
Acute Myocardial Infarction in Young Individuals.
Gulati R, Behfar A, Narula J, Kanwar A, Lerman A, Cooper L, Singh M
Mayo Clin Proc 2020 Jan;95(1):136-156. doi: 10.1016/j.mayocp.2019.05.001. PMID: 31902409
Prinzmetal angina.
Williams DS
J Insur Med 2009;41(1):77-9. PMID: 19518010

Therapy

Vasospastic angina: a review on diagnostic approach and management.
Jenkins K, Pompei G, Ganzorig N, Brown S, Beltrame J, Kunadian V
Ther Adv Cardiovasc Dis 2024 Jan-Dec;18:17539447241230400. doi: 10.1177/17539447241230400. PMID: 38343041Free PMC Article
Dietary inflammation index association with serum levels of nitric oxide, prostacyclin, and thromboxane B2 among prinzmetal angina patients and healthy persons.
Mohajeri M, Cicero AFG
Nutr Metab Cardiovasc Dis 2024 Apr;34(4):1054-1060. Epub 2023 Dec 2 doi: 10.1016/j.numecd.2023.11.018. PMID: 38233271
5-Fluorouracil, capecitabine and vasospasm: a scoping review of pathogenesis, management options and future research considerations.
Teperikidis E, Boulmpou A, Charalampidis P, Tsavousoglou C, Giannakoulas G, Papadopoulos CE, Vassilikos V
Acta Cardiol 2022 Feb;77(1):1-13. Epub 2021 Mar 8 doi: 10.1080/00015385.2021.1873548. PMID: 33683181
Prinzmetal angina: echocardiographic captured and angiographically proven without provocative testing.
Agrawal Y, Ponna PK, Halabi AR, Aloka F
BMJ Case Rep 2020 Sep 13;13(9) doi: 10.1136/bcr-2020-236353. PMID: 32928822Free PMC Article
Clinical picture. Prinzmetal angina.
Koschyk D, Münzel T, Brockhoff C, Meinertz T
Lancet 2000 Oct 21;356(9239):1434. doi: 10.1016/s0140-6736(00)03142-1. PMID: 11052600

Prognosis

Acute Myocardial Infarction in Young Individuals.
Gulati R, Behfar A, Narula J, Kanwar A, Lerman A, Cooper L, Singh M
Mayo Clin Proc 2020 Jan;95(1):136-156. doi: 10.1016/j.mayocp.2019.05.001. PMID: 31902409
Temporal Trends and Outcomes of Hospitalizations With Prinzmetal Angina: Perspectives From a National Database.
Elbadawi A, Elgendy IY, Naqvi SY, Mohamed AH, Ogunbayo GO, Omer MA, Mentias A, Saad M, Abbott JD, Jneid H, Bhatt DL
Am J Med 2019 Sep;132(9):1053-1061.e1. Epub 2019 Apr 29 doi: 10.1016/j.amjmed.2019.04.005. PMID: 31047867
Differential local spasticity in myocardial bridges.
Angelini P, Uribe C, Lozano P
Tex Heart Inst J 2012;39(3):384-8. PMID: 22719149Free PMC Article
Acute coronary syndrome in young adults.
Teixeira M, Sá I, Mendes JS, Martins L
Rev Port Cardiol 2010 Jun;29(6):947-55. PMID: 20964107
Prinzmetal angina.
Williams DS
J Insur Med 2009;41(1):77-9. PMID: 19518010

Clinical prediction guides

Temporal Trends and Outcomes of Hospitalizations With Prinzmetal Angina: Perspectives From a National Database.
Elbadawi A, Elgendy IY, Naqvi SY, Mohamed AH, Ogunbayo GO, Omer MA, Mentias A, Saad M, Abbott JD, Jneid H, Bhatt DL
Am J Med 2019 Sep;132(9):1053-1061.e1. Epub 2019 Apr 29 doi: 10.1016/j.amjmed.2019.04.005. PMID: 31047867
OCT-Defined Morphological Characteristics of Coronary Artery Spasm Sites in Vasospastic Angina.
Shin ES, Ann SH, Singh GB, Lim KH, Yoon HJ, Hur SH, Her AY, Koo BK, Akasaka T
JACC Cardiovasc Imaging 2015 Sep;8(9):1059-1067. Epub 2015 Aug 19 doi: 10.1016/j.jcmg.2015.03.010. PMID: 26298073
Differential local spasticity in myocardial bridges.
Angelini P, Uribe C, Lozano P
Tex Heart Inst J 2012;39(3):384-8. PMID: 22719149Free PMC Article
Different vasomotor action of nifedipine on dynamic coronary obstructions and therapeutic response in effort and prinzmetal angina.
Polese A, de Cesare N, Bartorelli A, Fabbiocchi F, Loaldi A, Montorsi P, Guazzi MD
Am J Med Sci 1989 Feb;297(2):73-9. doi: 10.1097/00000441-198902000-00003. PMID: 2919634
Transient changes in left ventricular mechanics during attacks of Prinzmetal angina: a two-dimensional echocardiographic study.
Distante A, Rovai D, Picano E, Moscarelli E, Morales MA, Palombo C, L'Abbate A
Am Heart J 1984 Sep;108(3 Pt 1):440-6. doi: 10.1016/0002-8703(84)90406-x. PMID: 6236683

Recent systematic reviews

Hyperventilation testing in the diagnosis of vasospastic angina: A clinical review and meta-analysis.
Boivin-Proulx LA, Marquis-Gravel G, Rousseau-Saine N, Harel F, Jolicoeur EM, Pelletier-Galarneau M
Eur J Clin Invest 2024 Jun;54(6):e14178. Epub 2024 Feb 13 doi: 10.1111/eci.14178. PMID: 38348627

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