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Silent myocardial infarction

MedGen UID:
83307
Concept ID:
C0340324
Disease or Syndrome
Synonyms: MI - Silent myocardial infarction; Silent Myocardial Infarction; silent myocardial infarction
SNOMED CT: Silent myocardial infarction (233843008); MI - Silent myocardial infarction (233843008)
 
Monarch Initiative: MONDO:0003678

Definition

A history of myocardial infarction in the absence of clinical symptoms and positive electrocardiographic findings. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSilent myocardial infarction

Professional guidelines

PubMed

Pek PP, Loy EY, Wah W, Ho AFW, Zheng H, Fook-Chong SMC, Chua TSJ, Koh TH, Chow KY, Liu N, Ong MEH
CJEM 2017 Sep;19(5):355-363. Epub 2016 Sep 29 doi: 10.1017/cem.2016.376. PMID: 27681496
Swoboda PP, McDiarmid AK, Erhayiem B, Haaf P, Kidambi A, Fent GJ, Dobson LE, Musa TA, Garg P, Law GR, Kearney MT, Barth JH, Ajjan R, Greenwood JP, Plein S
J Clin Endocrinol Metab 2016 Sep;101(9):3316-23. Epub 2016 Jun 14 doi: 10.1210/jc.2016-1318. PMID: 27300573Free PMC Article
Adabag AS, Peterson G, Apple FS, Titus J, King R, Luepker RV
Am Heart J 2010 Jan;159(1):33-9. doi: 10.1016/j.ahj.2009.10.019. PMID: 20102864Free PMC Article

Recent clinical studies

Etiology

Fonseca AC, Ferro JM, Almeida AG
J Neurol 2021 Jul;268(7):2597-2604. Epub 2021 Jan 13 doi: 10.1007/s00415-020-10393-6. PMID: 33439327
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
Circulation 2018 Nov 13;138(20):e618-e651. doi: 10.1161/CIR.0000000000000617. PMID: 30571511
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
Glob Heart 2018 Dec;13(4):305-338. Epub 2018 Aug 25 doi: 10.1016/j.gheart.2018.08.004. PMID: 30154043
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
J Am Coll Cardiol 2018 Oct 30;72(18):2231-2264. Epub 2018 Aug 25 doi: 10.1016/j.jacc.2018.08.1038. PMID: 30153967
Rogers T, Steinvil A, Torguson R, Waksman R
Cardiovasc Revasc Med 2016 Dec;17(8):522-527. Epub 2016 Oct 8 doi: 10.1016/j.carrev.2016.10.001. PMID: 27847262

Diagnosis

Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
Circulation 2018 Nov 13;138(20):e618-e651. doi: 10.1161/CIR.0000000000000617. PMID: 30571511
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
Glob Heart 2018 Dec;13(4):305-338. Epub 2018 Aug 25 doi: 10.1016/j.gheart.2018.08.004. PMID: 30154043
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
J Am Coll Cardiol 2018 Oct 30;72(18):2231-2264. Epub 2018 Aug 25 doi: 10.1016/j.jacc.2018.08.1038. PMID: 30153967
Rogers T, Steinvil A, Torguson R, Waksman R
Cardiovasc Revasc Med 2016 Dec;17(8):522-527. Epub 2016 Oct 8 doi: 10.1016/j.carrev.2016.10.001. PMID: 27847262
Goldberger AL
Cardiol Clin 1987 Aug;5(3):357-66. PMID: 3319161

Therapy

Goldberg RB, Orchard TJ, Crandall JP, Boyko EJ, Budoff M, Dabelea D, Gadde KM, Knowler WC, Lee CG, Nathan DM, Watson K, Temprosa M; Diabetes Prevention Program Research Group*
Circulation 2022 May 31;145(22):1632-1641. Epub 2022 May 23 doi: 10.1161/CIRCULATIONAHA.121.056756. PMID: 35603600Free PMC Article
Holmes DR Jr, Krucoff MW, Mullin C, Mikdadi G, Presser D, Wohns D, Kaplan A, Ciuffo A, Eberly AL 3rd, Iteld B, Fischell DR, Fischell T, Keenan D, John MS, Gibson CM
J Am Coll Cardiol 2019 Oct 22;74(16):2047-2055. doi: 10.1016/j.jacc.2019.07.084. PMID: 31623762
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
J Am Coll Cardiol 2018 Oct 30;72(18):2231-2264. Epub 2018 Aug 25 doi: 10.1016/j.jacc.2018.08.1038. PMID: 30153967
Rogers T, Steinvil A, Torguson R, Waksman R
Cardiovasc Revasc Med 2016 Dec;17(8):522-527. Epub 2016 Oct 8 doi: 10.1016/j.carrev.2016.10.001. PMID: 27847262
Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefèbvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J; PROactive Investigators
Lancet 2005 Oct 8;366(9493):1279-89. doi: 10.1016/S0140-6736(05)67528-9. PMID: 16214598

Prognosis

Ram P, Shah S, Patel B, Osman M, Bhatt K, Jaber W, Shah M
Int J Cardiol 2023 Jan 15;371:121-125. Epub 2022 Sep 6 doi: 10.1016/j.ijcard.2022.08.057. PMID: 36075461
Rogers T, Steinvil A, Torguson R, Waksman R
Cardiovasc Revasc Med 2016 Dec;17(8):522-527. Epub 2016 Oct 8 doi: 10.1016/j.carrev.2016.10.001. PMID: 27847262
Nielsen J, Juel J, Alzuhairi KS, Friis R, Graff C, Kanters JK, Jensen SE
Acta Neuropsychiatr 2015 Apr;27(2):106-12. Epub 2015 Jan 13 doi: 10.1017/neu.2014.41. PMID: 25582655
Gilling-Smith GL, McWilliams RG, Scurr JR, Brennan JA, Fisher RK, Harris PL, Vallabhaneni SR
Br J Surg 2008 Jun;95(6):703-8. doi: 10.1002/bjs.6179. PMID: 18446776
Sorrell VL, Callaway MJ, Zwischenberger JB, Schmedtje JF Jr
J Thorac Imaging 1994 Fall;9(4):258-9. doi: 10.1097/00005382-199423000-00007. PMID: 7830297

Clinical prediction guides

Ram P, Shah S, Patel B, Osman M, Bhatt K, Jaber W, Shah M
Int J Cardiol 2023 Jan 15;371:121-125. Epub 2022 Sep 6 doi: 10.1016/j.ijcard.2022.08.057. PMID: 36075461
Rogers T, Steinvil A, Torguson R, Waksman R
Cardiovasc Revasc Med 2016 Dec;17(8):522-527. Epub 2016 Oct 8 doi: 10.1016/j.carrev.2016.10.001. PMID: 27847262
Lee RM, Thompson JR, Eke T
Br J Ophthalmol 2016 Jun;100(6):772-6. Epub 2015 Sep 24 doi: 10.1136/bjophthalmol-2015-307060. PMID: 26405103
Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefèbvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J; PROactive Investigators
Lancet 2005 Oct 8;366(9493):1279-89. doi: 10.1016/S0140-6736(05)67528-9. PMID: 16214598
Dahlöf B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J; ASCOT Investigators
Lancet 2005 Sep 10-16;366(9489):895-906. doi: 10.1016/S0140-6736(05)67185-1. PMID: 16154016

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