U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Coronary artery spasm

MedGen UID:
3626
•Concept ID:
C0010073
•
Disease or Syndrome
Synonym: Coronary vasospasm
SNOMED CT: Coronary artery spasm (23687008); Coronary spasm (23687008)
 
HPO: HP:0025497
Monarch Initiative: MONDO:0005356

Definition

A brief and sudden narrowing of a coronary artery. [from HPO]

Professional guidelines

PubMed

Management of vasospastic angina.
Beltrame JF
Heart 2022 Dec 13;109(1):70-77. doi: 10.1136/heartjnl-2022-321268. PMID: 36371661
Treatment of Angina: Where Are We?
Balla C, Pavasini R, Ferrari R
Cardiology 2018;140(1):52-67. Epub 2018 Jun 6 doi: 10.1159/000487936. PMID: 29874661
Epidemiology, pathogenesis, and management of takotsubo syndrome.
Y-Hassan S, Tornvall P
Clin Auton Res 2018 Feb;28(1):53-65. Epub 2017 Sep 15 doi: 10.1007/s10286-017-0465-z. PMID: 28917022Free PMC Article

Recent clinical studies

Etiology

Myocardial Infarction with Nonobstructive Coronary Arteries.
Reynolds HR, Smilowitz NR
Annu Rev Med 2023 Jan 27;74:171-188. Epub 2022 Sep 30 doi: 10.1146/annurev-med-042921-111727. PMID: 36179347
Multi-national survey on the methods, efficacy, and safety on the post-approval clinical use of pulsed field ablation (MANIFEST-PF).
Ekanem E, Reddy VY, Schmidt B, Reichlin T, Neven K, Metzner A, Hansen J, Blaauw Y, Maury P, Arentz T, Sommer P, Anic A, Anselme F, Boveda S, Deneke T, Willems S, van der Voort P, Tilz R, Funasako M, Scherr D, Wakili R, Steven D, Kautzner J, Vijgen J, Jais P, Petru J, Chun J, Roten L, Füting A, Rillig A, Mulder BA, Johannessen A, Rollin A, Lehrmann H, Sohns C, Jurisic Z, Savoure A, Combes S, Nentwich K, Gunawardene M, Ouss A, Kirstein B, Manninger M, Bohnen JE, Sultan A, Peichl P, Koopman P, Derval N, Turagam MK, Neuzil P; MANIFEST-PF Cooperative
Europace 2022 Sep 1;24(8):1256-1266. doi: 10.1093/europace/euac050. PMID: 35647644Free PMC Article
Vasospastic angina: A literature review of current evidence.
Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O
Arch Cardiovasc Dis 2019 Jan;112(1):44-55. Epub 2018 Sep 7 doi: 10.1016/j.acvd.2018.08.002. PMID: 30197243
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990
Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need.
Ford TJ, Corcoran D, Berry C
Heart 2018 Feb;104(4):284-292. Epub 2017 Oct 13 doi: 10.1136/heartjnl-2017-311446. PMID: 29030424Free PMC Article

Diagnosis

Myocardial Infarction with Nonobstructive Coronary Arteries.
Reynolds HR, Smilowitz NR
Annu Rev Med 2023 Jan 27;74:171-188. Epub 2022 Sep 30 doi: 10.1146/annurev-med-042921-111727. PMID: 36179347
Vasospastic angina: A literature review of current evidence.
Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O
Arch Cardiovasc Dis 2019 Jan;112(1):44-55. Epub 2018 Sep 7 doi: 10.1016/j.acvd.2018.08.002. PMID: 30197243
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990
Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need.
Ford TJ, Corcoran D, Berry C
Heart 2018 Feb;104(4):284-292. Epub 2017 Oct 13 doi: 10.1136/heartjnl-2017-311446. PMID: 29030424Free PMC Article
Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management.
Kounis NG
Clin Chem Lab Med 2016 Oct 1;54(10):1545-59. doi: 10.1515/cclm-2016-0010. PMID: 26966931

Therapy

Activation of the monocytic α7 nicotinic acetylcholine receptor modulates oxidative stress and inflammation-associated development of coronary artery spasm via a p38 MAP-kinase signaling-dependent pathway.
Hung MY, Wu YH, Bamodu OA, Chen X, Lin YK, Hu P, Chang NC, Pang JS, Yeh CT
Free Radic Biol Med 2018 May 20;120:266-276. Epub 2018 Mar 31 doi: 10.1016/j.freeradbiomed.2018.03.050. PMID: 29609021
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990
Coronary artery spasm: review and update.
Hung MJ, Hu P, Hung MY
Int J Med Sci 2014;11(11):1161-71. Epub 2014 Aug 28 doi: 10.7150/ijms.9623. PMID: 25249785Free PMC Article
Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders.
Sorkin EM, Clissold SP
Drugs 1987 Apr;33(4):296-345. doi: 10.2165/00003495-198733040-00002. PMID: 3297616
Calcium-channel blocking agents.
Leonard RG, Talbert RL
Clin Pharm 1982 Jan-Feb;1(1):17-33. PMID: 6764159

Prognosis

Vasospastic angina: A literature review of current evidence.
Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O
Arch Cardiovasc Dis 2019 Jan;112(1):44-55. Epub 2018 Sep 7 doi: 10.1016/j.acvd.2018.08.002. PMID: 30197243
Treatment of Angina: Where Are We?
Balla C, Pavasini R, Ferrari R
Cardiology 2018;140(1):52-67. Epub 2018 Jun 6 doi: 10.1159/000487936. PMID: 29874661
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990
Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management.
Kounis NG
Clin Chem Lab Med 2016 Oct 1;54(10):1545-59. doi: 10.1515/cclm-2016-0010. PMID: 26966931
Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries.
Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF
Circulation 2015 Mar 10;131(10):861-70. Epub 2015 Jan 13 doi: 10.1161/CIRCULATIONAHA.114.011201. PMID: 25587100

Clinical prediction guides

Relation Between Cancer and Vasospastic Angina.
Matsumoto T, Saito Y, Saito K, Tateishi K, Kato K, Kitahara H, Kobayashi Y
Adv Ther 2021 Aug;38(8):4344-4353. Epub 2021 Jul 9 doi: 10.1007/s12325-021-01854-z. PMID: 34241778Free PMC Article
Coronary Artery Spasm as Related to Anxiety and Depression: A Nationwide Population-Based Study.
Hung MY, Mao CT, Hung MJ, Wang JK, Lee HC, Yeh CT, Hu P, Chen TH, Chang NC
Psychosom Med 2019 Apr;81(3):237-245. doi: 10.1097/PSY.0000000000000666. PMID: 30652987
Vasospastic angina: A literature review of current evidence.
Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O
Arch Cardiovasc Dis 2019 Jan;112(1):44-55. Epub 2018 Sep 7 doi: 10.1016/j.acvd.2018.08.002. PMID: 30197243
Coronary artery spasm: review and update.
Hung MJ, Hu P, Hung MY
Int J Med Sci 2014;11(11):1161-71. Epub 2014 Aug 28 doi: 10.7150/ijms.9623. PMID: 25249785Free PMC Article
Control of cardiac arrhythmias by calcium antagonism.
Nademanee K, Singh BN
Ann N Y Acad Sci 1988;522:536-52. doi: 10.1111/j.1749-6632.1988.tb33397.x. PMID: 3288060

Recent systematic reviews

Safety of intracoronary provocative testing for the diagnosis of coronary artery spasm.
Ciliberti G, Seshasai SRK, Ambrosio G, Kaski JC
Int J Cardiol 2017 Oct 1;244:77-83. Epub 2017 Jun 1 doi: 10.1016/j.ijcard.2017.05.109. PMID: 28622945
Takotsubo cardiomyopathy systematic review: Pathophysiologic process, clinical presentation and diagnostic approach to Takotsubo cardiomyopathy.
Ono R, Falcão LM
Int J Cardiol 2016 Apr 15;209:196-205. Epub 2016 Feb 3 doi: 10.1016/j.ijcard.2016.02.012. PMID: 26896623
Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries.
Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF
Circulation 2015 Mar 10;131(10):861-70. Epub 2015 Jan 13 doi: 10.1161/CIRCULATIONAHA.114.011201. PMID: 25587100
A systematic review of the pathophysiology of 5-fluorouracil-induced cardiotoxicity.
Polk A, Vistisen K, Vaage-Nilsen M, Nielsen DL
BMC Pharmacol Toxicol 2014 Sep 4;15:47. doi: 10.1186/2050-6511-15-47. PMID: 25186061Free PMC Article
Risks versus benefits of NSAIDs including aspirin in myocarditis: a review of the evidence from animal studies.
Meune C, Spaulding C, Mahé I, Lebon P, Bergmann JF
Drug Saf 2003;26(13):975-81. doi: 10.2165/00002018-200326130-00005. PMID: 14583071

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...