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Giant cell tumor

MedGen UID:
6598
•Concept ID:
C0017525
•
Neoplastic Process
Synonyms: Cell Tumor, Giant; Cell Tumors, Giant; Giant Cell Tumor; Giant Cell Tumors; Tumor, Giant Cell; Tumors, Giant Cell
SNOMED CT: Giant cell tumor (115238001); Giant cell tumor (443790001)
 
Monarch Initiative: MONDO:0002171

Definition

A benign, intermediate, or malignant neoplasm characterized by the presence of neoplastic giant cells. [from NCI]

Professional guidelines

PubMed

Updates on the Treatment of Tenosynovial Giant Cell Tumor.
Chan AS, Katiyar V, Dy P, Singh V
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):307-315. doi: 10.56875/2589-0646.1032. PMID: 37363972
CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment.
Wen J, Wang S, Guo R, Liu D
Eur J Med Chem 2023 Jan 5;245(Pt 1):114884. Epub 2022 Oct 29 doi: 10.1016/j.ejmech.2022.114884. PMID: 36335744
Editorial: Management of Bone Disorders in Children.
Crane JL, Misra M
Front Endocrinol (Lausanne) 2021;12:725655. Epub 2021 Jul 5 doi: 10.3389/fendo.2021.725655. PMID: 34290674Free PMC Article

Recent clinical studies

Etiology

Multicentric Giant Cell Tumor of Bone.
Errani C, Tsukamoto S, Angulo Alvarado R, Righi A, Nitta Y, Donati DM, Mavrogenis AF
Orthopedics 2023 Nov-Dec;46(6):e376-e380. Epub 2023 May 2 doi: 10.3928/01477447-20230426-05. PMID: 37126833
Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
Giant Cell Tumor of Soft Tissue: A Rare Entity.
Mavrogenis AF, Tsukamoto S, Antoniadou T, Righi A, Errani C
Orthopedics 2019 Jul 1;42(4):e364-e369. doi: 10.3928/01477447-20190624-04. PMID: 31323108
Giant cell tumor of bone.
Amanatullah DF, Clark TR, Lopez MJ, Borys D, Tamurian RM
Orthopedics 2014 Feb;37(2):112-20. doi: 10.3928/01477447-20140124-08. PMID: 24679193

Diagnosis

Multicentric Giant Cell Tumor of Bone.
Errani C, Tsukamoto S, Angulo Alvarado R, Righi A, Nitta Y, Donati DM, Mavrogenis AF
Orthopedics 2023 Nov-Dec;46(6):e376-e380. Epub 2023 May 2 doi: 10.3928/01477447-20230426-05. PMID: 37126833
Optimal Treatment for Tenosynovial Giant Cell Tumor of the Hand.
Kitagawa Y, Takai S
J Nippon Med Sch 2020 Sep 9;87(4):184-190. Epub 2020 Apr 30 doi: 10.1272/jnms.JNMS.2020_87-408. PMID: 32350187
Giant cell tumor of bone.
Amanatullah DF, Clark TR, Lopez MJ, Borys D, Tamurian RM
Orthopedics 2014 Feb;37(2):112-20. doi: 10.3928/01477447-20140124-08. PMID: 24679193
Giant cell tumor of bone.
Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375
Giant-cell tumor.
Gruenwald N, Demos TC, Lomasney LM, Rapp T
Orthopedics 2006 Feb;29(2):94, 167-71. doi: 10.3928/01477447-20060201-04. PMID: 16485448

Therapy

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Giant Cell Tumor of Bone: An Update.
Basu Mallick A, Chawla SP
Curr Oncol Rep 2021 Mar 22;23(5):51. doi: 10.1007/s11912-021-01047-5. PMID: 33754215
Pexidartinib: First Approval.
Lamb YN
Drugs 2019 Nov;79(16):1805-1812. doi: 10.1007/s40265-019-01210-0. PMID: 31602563Free PMC Article
Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial.
Tap WD, Gelderblom H, Palmerini E, Desai J, Bauer S, Blay JY, Alcindor T, Ganjoo K, Martín-Broto J, Ryan CW, Thomas DM, Peterfy C, Healey JH, van de Sande M, Gelhorn HL, Shuster DE, Wang Q, Yver A, Hsu HH, Lin PS, Tong-Starksen S, Stacchiotti S, Wagner AJ; ENLIVEN investigators
Lancet 2019 Aug 10;394(10197):478-487. Epub 2019 Jun 19 doi: 10.1016/S0140-6736(19)30764-0. PMID: 31229240Free PMC Article
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.
Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, Rey-Giraud F, Pradel LP, Feuerhake F, Klaman I, Jones T, Jucknischke U, Scheiblich S, Kaluza K, Gorr IH, Walz A, Abiraj K, Cassier PA, Sica A, Gomez-Roca C, de Visser KE, Italiano A, Le Tourneau C, Delord JP, Levitsky H, Blay JY, Rüttinger D
Cancer Cell 2014 Jun 16;25(6):846-59. Epub 2014 Jun 2 doi: 10.1016/j.ccr.2014.05.016. PMID: 24898549

Prognosis

Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
Tenosynovial giant cell tumor in the foot and ankle.
Çevik HB, Kayahan S, Eceviz E, Gümüştaş SA
Foot Ankle Surg 2020 Aug;26(6):712-716. Epub 2019 Sep 6 doi: 10.1016/j.fas.2019.08.014. PMID: 31526689
Locally Aggressive Connective Tissue Tumors.
Gounder MM, Thomas DM, Tap WD
J Clin Oncol 2018 Jan 10;36(2):202-209. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.75.8482. PMID: 29220303Free PMC Article
Giant cell tumor of bone.
Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375
Giant-cell tumor.
Gruenwald N, Demos TC, Lomasney LM, Rapp T
Orthopedics 2006 Feb;29(2):94, 167-71. doi: 10.3928/01477447-20060201-04. PMID: 16485448

Clinical prediction guides

Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
Optimal Treatment for Tenosynovial Giant Cell Tumor of the Hand.
Kitagawa Y, Takai S
J Nippon Med Sch 2020 Sep 9;87(4):184-190. Epub 2020 Apr 30 doi: 10.1272/jnms.JNMS.2020_87-408. PMID: 32350187
Locally Aggressive Connective Tissue Tumors.
Gounder MM, Thomas DM, Tap WD
J Clin Oncol 2018 Jan 10;36(2):202-209. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.75.8482. PMID: 29220303Free PMC Article
Benign tumors of the spine.
Thakur NA, Daniels AH, Schiller J, Valdes MA, Czerwein JK, Schiller A, Esmende S, Terek RM
J Am Acad Orthop Surg 2012 Nov;20(11):715-24. doi: 10.5435/JAAOS-20-11-715. PMID: 23118137

Recent systematic reviews

The giant cell tumor during pregnancy: A review of literature.
Formica VM, Bruno V, Scotto Di Uccio A, Cocca E, Rossi B, Zoccali C
Orthop Traumatol Surg Res 2023 May;109(3):103396. Epub 2022 Sep 7 doi: 10.1016/j.otsr.2022.103396. PMID: 36087835
Management of giant cell tumors of the distal radius: a systematic review and meta-analysis.
Koucheki R, Gazendam A, Perera J, Griffin A, Ferguson P, Wunder J, Tsoi K
Eur J Orthop Surg Traumatol 2023 May;33(4):759-772. Epub 2022 Mar 30 doi: 10.1007/s00590-022-03252-9. PMID: 35377078
Management of spinal giant cell tumors.
Luksanapruksa P, Buchowski JM, Singhatanadgige W, Rose PC, Bumpass DB
Spine J 2016 Feb;16(2):259-69. Epub 2015 Oct 30 doi: 10.1016/j.spinee.2015.10.045. PMID: 26523962
Giant cell tumor of the pelvis: a systematic review.
Zheng K, Wang Z, Wu SJ, Ye ZM, Xu SF, Xu M, Hu YC, Yu XC
Orthop Surg 2015 May;7(2):102-7. doi: 10.1111/os.12174. PMID: 26033989Free PMC Article
Therapeutic radiotherapy for giant cell tumor of the spine: a systemic review.
Ma Y, Xu W, Yin H, Huang Q, Liu T, Yang X, Wei H, Xiao J
Eur Spine J 2015 Aug;24(8):1754-60. Epub 2015 May 6 doi: 10.1007/s00586-015-3834-0. PMID: 25943724

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