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Giant cell tumor

MedGen UID:: 6598
•Concept ID:: C0017525
•: Neoplastic Process

Synonyms:	Cell Tumor, Giant; Cell Tumors, Giant; Giant Cell Tumor; Giant Cell Tumors; Tumor, Giant Cell; Tumors, Giant Cell
SNOMED CT:	Giant cell tumor (115238001); Giant cell tumor (443790001)

Monarch Initiative:	MONDO:0002171

Definition

A benign, intermediate, or malignant neoplasm characterized by the presence of neoplastic giant cells. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGiant cell tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Connective and Soft Tissue Disorder
        Connective and soft tissue neoplasm
        Giant cell tumor
        Giant cell tumor of bone
        Giant cell tumor of soft tissue
        Malignant giant cell tumor
        Giant Cell Carcinoma
        Gallbladder Undifferentiated Carcinoma, Spindle and Giant Cell Type
        Laryngeal Giant Cell Carcinoma
        Lung giant cell carcinoma
        Giant cell glioblastoma
        Adult Giant Cell Glioblastoma
        Childhood Giant Cell Glioblastoma
        Recurrent Giant Cell Glioblastoma
        Refractory Giant Cell Glioblastoma
        Malignant giant cell tumor of soft parts
        Malignant Osteoclastic Giant Cell-Rich Tumor of Bone
        Malignancy in giant cell tumor of bone
        Malignant tenosynovial giant cell tumor
        Osteoclastic Giant Cell-Rich Tumor of Bone
        Benign Osteoclastic Giant Cell-Rich Tumor of Bone
        Giant Cell Lesion of Small Bones
        Intermediate Osteoclastic Giant Cell-Rich Tumor of Bone
        Tenosynovial giant cell tumor
        Tenosynovial giant cell tumor, diffuse type
        Tenosynovial giant cell tumor, localized type

Professional guidelines

PubMed

CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment.

Wen J, Wang S, Guo R, Liu D
Eur J Med Chem 2023 Jan 5;245(Pt 1):114884. Epub 2022 Oct 29 doi: 10.1016/j.ejmech.2022.114884. PMID: 36335744

Editorial: Management of Bone Disorders in Children.

Crane JL, Misra M
Front Endocrinol (Lausanne) 2021;12:725655. Epub 2021 Jul 5 doi: 10.3389/fendo.2021.725655. PMID: 34290674 Free PMC Article

Bone cancer.

Biermann JS, Adkins DR, Agulnik M, Benjamin RS, Brigman B, Butrynski JE, Cheong D, Chow W, Curry WT, Frassica DA, Frassica FJ, Hande KR, Hornicek FJ, Jones RL, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, von Mehren M, Bergman MA, Sundar H; National complrehensive cancer network
J Natl Compr Canc Netw 2013 Jun 1;11(6):688-723. doi: 10.6004/jnccn.2013.0088. PMID: 23744868

See all (158)

Recent clinical studies

Etiology

Multicentric Giant Cell Tumor of Bone.

Errani C, Tsukamoto S, Angulo Alvarado R, Righi A, Nitta Y, Donati DM, Mavrogenis AF
Orthopedics 2023 Nov-Dec;46(6):e376-e380. Epub 2023 May 2 doi: 10.3928/01477447-20230426-05. PMID: 37126833

Tenosynovial giant cell tumor.

Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897

Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.

Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433 Free PMC Article

Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options.

Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024

Giant cell tumor of bone.

Amanatullah DF, Clark TR, Lopez MJ, Borys D, Tamurian RM
Orthopedics 2014 Feb;37(2):112-20. doi: 10.3928/01477447-20140124-08. PMID: 24679193

See all (1203)

Diagnosis

Multicentric Giant Cell Tumor of Bone.

Errani C, Tsukamoto S, Angulo Alvarado R, Righi A, Nitta Y, Donati DM, Mavrogenis AF
Orthopedics 2023 Nov-Dec;46(6):e376-e380. Epub 2023 May 2 doi: 10.3928/01477447-20230426-05. PMID: 37126833

Giant cell tumor of bone.

Amanatullah DF, Clark TR, Lopez MJ, Borys D, Tamurian RM
Orthopedics 2014 Feb;37(2):112-20. doi: 10.3928/01477447-20140124-08. PMID: 24679193

Giant cell tumor of bone.

Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375

Giant Cell Tumor (tumor gigantocellularis, osteoclastoma) - epidemiology, diagnosis, treatment.

Karpik M
Ortop Traumatol Rehabil 2010 May-Jun;12(3):207-15. PMID: 20675862

Giant-cell tumor.

Gruenwald N, Demos TC, Lomasney LM, Rapp T
Orthopedics 2006 Feb;29(2):94, 167-71. doi: 10.3928/01477447-20060201-04. PMID: 16485448

See all (1737)

Therapy

Tenosynovial giant cell tumor.

Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897

Giant Cell Tumor of Bone: An Update.

Basu Mallick A, Chawla SP
Curr Oncol Rep 2021 Mar 22;23(5):51. doi: 10.1007/s11912-021-01047-5. PMID: 33754215

Pexidartinib: First Approval.

Lamb YN
Drugs 2019 Nov;79(16):1805-1812. doi: 10.1007/s40265-019-01210-0. PMID: 31602563 Free PMC Article

Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial.

Tap WD, Gelderblom H, Palmerini E, Desai J, Bauer S, Blay JY, Alcindor T, Ganjoo K, Martín-Broto J, Ryan CW, Thomas DM, Peterfy C, Healey JH, van de Sande M, Gelhorn HL, Shuster DE, Wang Q, Yver A, Hsu HH, Lin PS, Tong-Starksen S, Stacchiotti S, Wagner AJ; ENLIVEN investigators
Lancet 2019 Aug 10;394(10197):478-487. Epub 2019 Jun 19 doi: 10.1016/S0140-6736(19)30764-0. PMID: 31229240 Free PMC Article

Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.

Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, Rey-Giraud F, Pradel LP, Feuerhake F, Klaman I, Jones T, Jucknischke U, Scheiblich S, Kaluza K, Gorr IH, Walz A, Abiraj K, Cassier PA, Sica A, Gomez-Roca C, de Visser KE, Italiano A, Le Tourneau C, Delord JP, Levitsky H, Blay JY, Rüttinger D
Cancer Cell 2014 Jun 16;25(6):846-59. Epub 2014 Jun 2 doi: 10.1016/j.ccr.2014.05.016. PMID: 24898549

See all (622)

Prognosis

Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.

Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433 Free PMC Article

Giant Cell Tumor of Bone Versus Tenosynovial Giant Cell Tumor - Similarities and Differences.

Kropivšek L, Pižem J, Mavčič B
Int J Surg Pathol 2022 Sep;30(6):596-605. Epub 2022 Jan 31 doi: 10.1177/10668969221076545. PMID: 35098753

Tenosynovial giant cell tumor in the foot and ankle.

Çevik HB, Kayahan S, Eceviz E, Gümüştaş SA
Foot Ankle Surg 2020 Aug;26(6):712-716. Epub 2019 Sep 6 doi: 10.1016/j.fas.2019.08.014. PMID: 31526689

Giant cell tumor of bone.

Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375

Giant-cell tumor.

Gruenwald N, Demos TC, Lomasney LM, Rapp T
Orthopedics 2006 Feb;29(2):94, 167-71. doi: 10.3928/01477447-20060201-04. PMID: 16485448

See all (915)

Clinical prediction guides

Giant cell tumour of bone.

Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582

Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.

Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433 Free PMC Article

Malignant giant cell tumour of bone: a review of clinical, pathological and imaging features.

Tahir I, Andrei V, Pollock R, Saifuddin A
Skeletal Radiol 2022 May;51(5):957-970. Epub 2021 Sep 25 doi: 10.1007/s00256-021-03913-6. PMID: 34562125

Optimal Treatment for Tenosynovial Giant Cell Tumor of the Hand.

Kitagawa Y, Takai S
J Nippon Med Sch 2020 Sep 9;87(4):184-190. Epub 2020 Apr 30 doi: 10.1272/jnms.JNMS.2020_87-408. PMID: 32350187

Locally Aggressive Connective Tissue Tumors.

Gounder MM, Thomas DM, Tap WD
J Clin Oncol 2018 Jan 10;36(2):202-209. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.75.8482. PMID: 29220303 Free PMC Article

See all (827)

Recent systematic reviews

The giant cell tumor during pregnancy: A review of literature.

Formica VM, Bruno V, Scotto Di Uccio A, Cocca E, Rossi B, Zoccali C
Orthop Traumatol Surg Res 2023 May;109(3):103396. Epub 2022 Sep 7 doi: 10.1016/j.otsr.2022.103396. PMID: 36087835

Management of giant cell tumors of the distal radius: a systematic review and meta-analysis.

Koucheki R, Gazendam A, Perera J, Griffin A, Ferguson P, Wunder J, Tsoi K
Eur J Orthop Surg Traumatol 2023 May;33(4):759-772. Epub 2022 Mar 30 doi: 10.1007/s00590-022-03252-9. PMID: 35377078

Management of Tenosynovial Giant Cell Tumor: A Neoplastic and Inflammatory Disease.

Healey JH, Bernthal NM, van de Sande M
J Am Acad Orthop Surg Glob Res Rev 2020 Nov;4(11):e20.00028. doi: 10.5435/JAAOSGlobal-D-20-00028. PMID: 33156160 Free PMC Article

Management of spinal giant cell tumors.

Luksanapruksa P, Buchowski JM, Singhatanadgige W, Rose PC, Bumpass DB
Spine J 2016 Feb;16(2):259-69. Epub 2015 Oct 30 doi: 10.1016/j.spinee.2015.10.045. PMID: 26523962

Giant cell tumor of the pelvis: a systematic review.

Zheng K, Wang Z, Wu SJ, Ye ZM, Xu SF, Xu M, Hu YC, Yu XC
Orthop Surg 2015 May;7(2):102-7. doi: 10.1111/os.12174. PMID: 26033989 Free PMC Article

See all (44)

MedGen

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Giant cell tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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