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Cystadenoma

MedGen UID:
8221
•Concept ID:
C0010633
•
Neoplastic Process
Synonym: Cystadenomas
SNOMED CT: Cystadenoma (47620003); Cystoma (47620003)
 
Monarch Initiative: MONDO:0002369

Definition

A benign or borderline cystic epithelial neoplasm arising from the glandular epithelium. The epithelial cells line the cystic spaces which contain serous or mucinous fluid. Representative examples include ovarian and pancreatic cystadenomas. [from NCI]

Professional guidelines

PubMed

Diagnosis and Management of Pancreatic Cysts.
Gardner TB, Park WG, Allen PJ
Gastroenterology 2024 Aug;167(3):454-468. Epub 2024 Mar 3 doi: 10.1053/j.gastro.2024.02.041. PMID: 38442782
Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.
Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Updates in diagnosis and management of pancreatic cysts.
Lee LS
World J Gastroenterol 2021 Sep 14;27(34):5700-5714. doi: 10.3748/wjg.v27.i34.5700. PMID: 34629795Free PMC Article

Recent clinical studies

Diagnosis

Constitutional Mutation of PIK3CA: A Variant of Cowden Syndrome?
Vida-Navas E, Barca-Tierno V, López-Gómez V, Salazar MT, Moreno-Pelayo MA, Guillén-Ponce C
Genes (Basel) 2024 Sep 15;15(9) doi: 10.3390/genes15091209. PMID: 39336800Free PMC Article

Therapy

Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study.
Else T, Jonasch E, Iliopoulos O, Beckermann KE, Narayan V, Maughan BL, Oudard S, Maranchie JK, Iversen AB, Goldberg CM, Fu W, Perini RF, Liu Y, Linehan WM, Srinivasan R
Clin Cancer Res 2024 May 1;30(9):1750-1757. doi: 10.1158/1078-0432.CCR-23-2592. PMID: 38393723Free PMC Article
Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex.
Astrinidis A, Li C, Zhang EY, Zhao X, Zhao S, Guo M, Olatoke T, Mattam U, Huang R, Zhang AG, Pitstick L, Kopras EJ, Gupta N, Jandarov R, Smith EP, Fugate E, Lindquist D, Markiewski MM, Karbowniczek M, Wikenheiser-Brokamp KA, Setchell KDR, McCormack FX, Xu Y, Yu JJ
JCI Insight 2023 May 8;8(9) doi: 10.1172/jci.insight.166850. PMID: 36927688Free PMC Article
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765
Diagnostic ERCP.
Ponchon T, Pilleul F
Endoscopy 2002 Jan;34(1):29-42. doi: 10.1055/s-2002-19397. PMID: 11778128

Prognosis

Primary retroperitoneal tumor: mucinous cystoadenocarcinoma.
Toffolo Pasquini M, Aragone L, Scasso Rebdza V, Nardi W, Toscano M, Quildrian S
Medicina (B Aires) 2024;84(4):750-755. PMID: 39172576
Low-grade Serous Neoplasia of the Female Genital Tract.
Folkins AK, Longacre TA
Surg Pathol Clin 2019 Jun;12(2):481-513. doi: 10.1016/j.path.2019.02.006. PMID: 31097112
Intraductal papillary mucinous neoplasms and mucinous cystadenomas: current status and recommendations.
Moris M, Wallace MB
Rev Esp Enferm Dig 2017 May;109(5):358-367. doi: 10.17235/reed.2017.4630/2016. PMID: 28112959
Diagnosis and treatment of cystic pancreatic tumors.
Al-Haddad M, Schmidt MC, Sandrasegaran K, Dewitt J
Clin Gastroenterol Hepatol 2011 Aug;9(8):635-48. Epub 2011 Mar 11 doi: 10.1016/j.cgh.2011.03.005. PMID: 21397725
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765

Clinical prediction guides

Diagnosis and Management of Pancreatic Cysts.
Gardner TB, Park WG, Allen PJ
Gastroenterology 2024 Aug;167(3):454-468. Epub 2024 Mar 3 doi: 10.1053/j.gastro.2024.02.041. PMID: 38442782
Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.
Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Clinical approach to incidental pancreatic cysts.
Chiang AL, Lee LS
World J Gastroenterol 2016 Jan 21;22(3):1236-45. doi: 10.3748/wjg.v22.i3.1236. PMID: 26811661Free PMC Article
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
Evaluation of hepatic cystic lesions.
Lantinga MA, Gevers TJ, Drenth JP
World J Gastroenterol 2013 Jun 21;19(23):3543-54. doi: 10.3748/wjg.v19.i23.3543. PMID: 23801855Free PMC Article

Recent systematic reviews

Diagnosis and Treatment of a Mixed Epithelial Stromal Tumor of the Seminal Vesicle: A Systematic Review.
Babar M, Matloubieh J, Macdonald E, Cheng J, Aboumohamed A, Watts K
Urology 2022 Sep;167:13-18. Epub 2022 Feb 26 doi: 10.1016/j.urology.2022.02.012. PMID: 35231450
Benign parotid mass and facial palsy: systematic review.
Stewart KE, Bannon R, Bannister M
Ann R Coll Surg Engl 2021 Jan;103(1):47-52. Epub 2020 Sep 24 doi: 10.1308/rcsann.2020.0194. PMID: 32969265Free PMC Article
Diagnostic performance of endoscopic ultrasound through-the-needle microforceps biopsy of pancreatic cystic lesions: Systematic review with meta-analysis.
Tacelli M, Celsa C, Magro B, Barchiesi M, Barresi L, Capurso G, Arcidiacono PG, Cammà C, Crinò SF
Dig Endosc 2020 Nov;32(7):1018-1030. Epub 2020 Feb 26 doi: 10.1111/den.13626. PMID: 31912580
Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Pancreatic lesions in von Hippel-Lindau disease? A systematic review and meta-synthesis of the literature.
Charlesworth M, Verbeke CS, Falk GA, Walsh M, Smith AM, Morris-Stiff G
J Gastrointest Surg 2012 Jul;16(7):1422-8. Epub 2012 Feb 28 doi: 10.1007/s11605-012-1847-0. PMID: 22370733

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