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Pancreatic serous cystadenoma

MedGen UID:
233833
•Concept ID:
C1335316
•
Neoplastic Process
Synonyms: pancreas serous cystadenoma; Pancreatic Microcystic Adenoma; pancreatic microcystic adenoma; Pancreatic Serous Cystadenoma; pancreatic serous cystadenoma; PSC; Serous cystadenoma of pancreas; Serous Cystadenoma of Pancreas; serous cystadenoma of pancreas; Serous Cystadenoma of the Pancreas; serous cystadenoma of the pancreas
SNOMED CT: Serous cystadenoma of pancreas (690761000119100)
 
Monarch Initiative: MONDO:0002808

Definition

A benign, non-metastasizing cystic epithelial neoplasm arising from the exocrine pancreas. It is composed of glycogen-rich epithelial cells which produce a watery fluid. Signs and symptoms include abdominal mass, abdominal pain, nausea, vomiting, and weight loss. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic serous cystadenoma

Professional guidelines

PubMed

Extracellular vesicle analysis of plasma allows differential diagnosis of atypical pancreatic serous cystadenoma.
Yang KS, O'Shea A, Zelga P, Liss AS, Del Castillo CF, Weissleder R
Sci Rep 2023 Jul 6;13(1):10969. doi: 10.1038/s41598-023-37966-5. PMID: 37414831Free PMC Article
Differential diagnosis of pancreatic serous cystadenoma and mucinous cystadenoma: utility of textural features in combination with morphological characteristics.
Yang J, Guo X, Zhang H, Zhang W, Song J, Xu H, Ma X
BMC Cancer 2019 Dec 16;19(1):1223. doi: 10.1186/s12885-019-6421-7. PMID: 31842793Free PMC Article

Recent clinical studies

Etiology

Radiomics Based on Contrast-Enhanced Ultrasound Images for Diagnosis of Pancreatic Serous Cystadenoma.
Zhang Y, Yao J, Liu F, Cheng Z, Qi E, Han Z, Yu J, Dou J, Liang P, Tan S, Dong X, Li X, Sun Y, Wang S, Wang Z, Yu X
Ultrasound Med Biol 2023 Dec;49(12):2469-2475. Epub 2023 Sep 24 doi: 10.1016/j.ultrasmedbio.2023.08.007. PMID: 37749013
Differential diagnosis of pancreatic serous cystadenoma and mucinous cystadenoma: utility of textural features in combination with morphological characteristics.
Yang J, Guo X, Zhang H, Zhang W, Song J, Xu H, Ma X
BMC Cancer 2019 Dec 16;19(1):1223. doi: 10.1186/s12885-019-6421-7. PMID: 31842793Free PMC Article
Cytohistological diagnosis of pancreatic serous cystadenoma: a multimodal approach.
Steel M, Rao S, Ho J, Donnellan F, Yang HM, Schaeffer DF
J Clin Pathol 2019 Sep;72(9):615-621. Epub 2019 Jun 23 doi: 10.1136/jclinpath-2019-205872. PMID: 31235542
Characterization of pancreatic serous cystadenoma on dual-phase multidetector computed tomography.
Chu LC, Singhi AD, Hruban RH, Fishman EK
J Comput Assist Tomogr 2014 Mar-Apr;38(2):258-63. doi: 10.1097/RCT.10.1097/RCT.0b013e3182ab1556. PMID: 24632937Free PMC Article
Neuroendocrine markers expression in pancreatic serous cystadenoma.
Kanehira K, Khoury T
Appl Immunohistochem Mol Morphol 2011 Mar;19(2):141-6. doi: 10.1097/PAI.0b013e3181f5023d. PMID: 21030861

Diagnosis

Imaging of pancreatic serous cystadenoma and common imitators.
Lopes Vendrami C, Hammond NA, Escobar DJ, Zilber Z, Dwyer M, Moreno CC, Mittal PK, Miller FH
Abdom Radiol (NY) 2024 Oct;49(10):3666-3685. Epub 2024 Jun 2 doi: 10.1007/s00261-024-04337-1. PMID: 38825609
ABCD1 as a Novel Diagnostic Marker for Solid Pseudopapillary Neoplasm of the Pancreas.
Liu YA, Liu Y, Tu J, Shi Y, Pang J, Huang Q, Wang X, Lin Z, Zhao Y, Wang W, Peng J, Wu W
Am J Surg Pathol 2024 May 1;48(5):511-520. Epub 2024 Apr 3 doi: 10.1097/PAS.0000000000002205. PMID: 38567813Free PMC Article
Cytohistological diagnosis of pancreatic serous cystadenoma: a multimodal approach.
Steel M, Rao S, Ho J, Donnellan F, Yang HM, Schaeffer DF
J Clin Pathol 2019 Sep;72(9):615-621. Epub 2019 Jun 23 doi: 10.1136/jclinpath-2019-205872. PMID: 31235542
The honeycomb pattern of pancreatic serous cystadenoma.
Giambelluca D, Bruno A, Picone D, Midiri M
Abdom Radiol (NY) 2019 Mar;44(3):1191-1192. doi: 10.1007/s00261-018-1796-5. PMID: 30288583
The many faces of pancreatic serous cystadenoma: Radiologic and pathologic correlation.
Chu LC, Singhi AD, Haroun RR, Hruban RH, Fishman EK
Diagn Interv Imaging 2017 Mar;98(3):191-202. Epub 2016 Sep 7 doi: 10.1016/j.diii.2016.08.005. PMID: 27614585

Therapy

Radiomics Based on Contrast-Enhanced Ultrasound Images for Diagnosis of Pancreatic Serous Cystadenoma.
Zhang Y, Yao J, Liu F, Cheng Z, Qi E, Han Z, Yu J, Dou J, Liang P, Tan S, Dong X, Li X, Sun Y, Wang S, Wang Z, Yu X
Ultrasound Med Biol 2023 Dec;49(12):2469-2475. Epub 2023 Sep 24 doi: 10.1016/j.ultrasmedbio.2023.08.007. PMID: 37749013
Pancreatic serous cystadenoma with a positive octreotide scan.
Canakis A, Kesar V, Hardy N, Legesse TB, Darwin P
Gastrointest Endosc 2022 Jun;95(6):1269-1270. Epub 2022 Feb 2 doi: 10.1016/j.gie.2022.01.022. PMID: 35122809
A novel approach to the diagnosis of pancreatic serous cystadenoma: needle-based confocal laser endomicroscopy.
Napoléon B, Lemaistre AI, Pujol B, Caillol F, Lucidarme D, Bourdariat R, Morellon-Mialhe B, Fumex F, Lefort C, Lepilliez V, Palazzo L, Monges G, Filoche B, Giovannini M
Endoscopy 2015 Jan;47(1):26-32. Epub 2014 Oct 17 doi: 10.1055/s-0034-1390693. PMID: 25325684
Pancreatic tuberculosis masquerading as pancreatic serous cystadenoma.
Hong SG, Kim JS, Joo MK, Lee KG, Kim KH, Oh CR, Park JJ, Bak YT
World J Gastroenterol 2009 Feb 28;15(8):1010-3. doi: 10.3748/wjg.15.1010. PMID: 19248204Free PMC Article
Surgical treatment of pancreatic serous cystadenoma: aggressive for operations but limited resections.
Hung JS, Yang CY, Hu RH, Lee PH, Tien YW
Pancreas 2007 Nov;35(4):358-60. doi: 10.1097/mpa.0b013e318095a89e. PMID: 18090243

Prognosis

Classification prediction of pancreatic cystic neoplasms based on radiomics deep learning models.
Liang W, Tian W, Wang Y, Wang P, Wang Y, Zhang H, Ruan S, Shao J, Zhang X, Huang D, Ding Y, Bai X
BMC Cancer 2022 Nov 29;22(1):1237. doi: 10.1186/s12885-022-10273-4. PMID: 36447168Free PMC Article
Cytohistological diagnosis of pancreatic serous cystadenoma: a multimodal approach.
Steel M, Rao S, Ho J, Donnellan F, Yang HM, Schaeffer DF
J Clin Pathol 2019 Sep;72(9):615-621. Epub 2019 Jun 23 doi: 10.1136/jclinpath-2019-205872. PMID: 31235542
Laparoscopic fenestration of pancreatic serous cystadenoma: Minimally invasive approach for symptomatic benign disease.
Dokmak S, Aussilhou B, Rasoaherinomenjanahary F, Sauvanet A, Vullierme MP, Rebours V, Lévy P
World J Gastroenterol 2015 Jun 14;21(22):7047-51. doi: 10.3748/wjg.v21.i22.7047. PMID: 26078583Free PMC Article
A novel approach to the diagnosis of pancreatic serous cystadenoma: needle-based confocal laser endomicroscopy.
Napoléon B, Lemaistre AI, Pujol B, Caillol F, Lucidarme D, Bourdariat R, Morellon-Mialhe B, Fumex F, Lefort C, Lepilliez V, Palazzo L, Monges G, Filoche B, Giovannini M
Endoscopy 2015 Jan;47(1):26-32. Epub 2014 Oct 17 doi: 10.1055/s-0034-1390693. PMID: 25325684
Fine-needle aspiration of pancreatic serous cystadenoma: cytologic features and diagnostic pitfalls.
Huang P, Staerkel G, Sneige N, Gong Y
Cancer 2006 Aug 25;108(4):239-49. doi: 10.1002/cncr.21911. PMID: 16691573

Clinical prediction guides

ABCD1 as a Novel Diagnostic Marker for Solid Pseudopapillary Neoplasm of the Pancreas.
Liu YA, Liu Y, Tu J, Shi Y, Pang J, Huang Q, Wang X, Lin Z, Zhao Y, Wang W, Peng J, Wu W
Am J Surg Pathol 2024 May 1;48(5):511-520. Epub 2024 Apr 3 doi: 10.1097/PAS.0000000000002205. PMID: 38567813Free PMC Article
Classification prediction of pancreatic cystic neoplasms based on radiomics deep learning models.
Liang W, Tian W, Wang Y, Wang P, Wang Y, Zhang H, Ruan S, Shao J, Zhang X, Huang D, Ding Y, Bai X
BMC Cancer 2022 Nov 29;22(1):1237. doi: 10.1186/s12885-022-10273-4. PMID: 36447168Free PMC Article
Pancreatic Acinar Cell Cystadenoma Mimicking Pancreatic Serous Cystadenoma.
Lee JH, Jung SJ, Park YH, Park SJ, Choi JS
Korean J Gastroenterol 2021 Aug 25;78(2):138-143. doi: 10.4166/kjg.2021.044. PMID: 34446637
Cytohistological diagnosis of pancreatic serous cystadenoma: a multimodal approach.
Steel M, Rao S, Ho J, Donnellan F, Yang HM, Schaeffer DF
J Clin Pathol 2019 Sep;72(9):615-621. Epub 2019 Jun 23 doi: 10.1136/jclinpath-2019-205872. PMID: 31235542
A novel approach to the diagnosis of pancreatic serous cystadenoma: needle-based confocal laser endomicroscopy.
Napoléon B, Lemaistre AI, Pujol B, Caillol F, Lucidarme D, Bourdariat R, Morellon-Mialhe B, Fumex F, Lefort C, Lepilliez V, Palazzo L, Monges G, Filoche B, Giovannini M
Endoscopy 2015 Jan;47(1):26-32. Epub 2014 Oct 17 doi: 10.1055/s-0034-1390693. PMID: 25325684

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