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Mucoepidermoid carcinoma of parotid gland

MedGen UID:
277506
•Concept ID:
C1335363
•
Neoplastic Process
Synonyms: Cancer of parotid gland, mucoepidermoid; Mucoepidermoid Carcinoma of Parotid; mucoepidermoid carcinoma of parotid; Mucoepidermoid Carcinoma of Parotid Gland; mucoepidermoid carcinoma of parotid gland; Mucoepidermoid Carcinoma of the Parotid; mucoepidermoid carcinoma of the parotid; Mucoepidermoid Carcinoma of the Parotid Gland; mucoepidermoid carcinoma of the parotid gland; Parotid Gland Mucoepidermoid Carcinoma; parotid gland mucoepidermoid carcinoma; Parotid Mucoepidermoid Carcinoma; parotid mucoepidermoid carcinoma
SNOMED CT: Mucoepidermoid carcinoma of parotid gland (423793008); Cancer of parotid gland, mucoepidermoid (423793008)
 
Monarch Initiative: MONDO:0021280

Definition

A carcinoma that arises from the parotid gland. It usually presents as a firm and painless mass. It is characterized by the presence of epidermoid cells, mucus producing cells, and cells of intermediate type. It usually spreads to pre-auricular lymph nodes. The majority of cases have a favorable outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucoepidermoid carcinoma of parotid gland

Professional guidelines

PubMed

Mucoepidermoid carcinoma of the parotid gland: Twenty-year experience in treatment and outcomes.
Chan SA, Van Abel KM, Lewis JE, Routman DM, Garcia JJ, Karp EE, Price DL, Janus JR, Kasperbauer JL, Moore EJ
Head Neck 2021 Sep;43(9):2663-2671. Epub 2021 May 1 doi: 10.1002/hed.26735. PMID: 33931913
Diagnosis and Management of Malignant Salivary Gland Tumors of the Parotid Gland.
Lewis AG, Tong T, Maghami E
Otolaryngol Clin North Am 2016 Apr;49(2):343-80. doi: 10.1016/j.otc.2015.11.001. PMID: 27040585
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116

Recent clinical studies

Etiology

Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.
Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Salivary gland tumours: an epidemiological review of non-neoplastic and neoplastic pathology.
Mckenzie J, Lockyer J, Singh T, Nguyen E
Br J Oral Maxillofac Surg 2023 Jan;61(1):12-18. Epub 2022 Dec 9 doi: 10.1016/j.bjoms.2022.11.281. PMID: 36623970
Clinicopathological Predictors of Survival for Parotid Mucoepidermoid Carcinoma: A Systematic Review.
Cheng EY, Kim JH, Grose EM, Philteos J, Levin M, de Almeida J, Goldstein D
Otolaryngol Head Neck Surg 2023 Apr;168(4):611-618. Epub 2023 Feb 5 doi: 10.1177/01945998221086845. PMID: 35316125
Mucoepidermoid carcinoma of the parotid gland: Twenty-year experience in treatment and outcomes.
Chan SA, Van Abel KM, Lewis JE, Routman DM, Garcia JJ, Karp EE, Price DL, Janus JR, Kasperbauer JL, Moore EJ
Head Neck 2021 Sep;43(9):2663-2671. Epub 2021 May 1 doi: 10.1002/hed.26735. PMID: 33931913
Parotid gland tumors: a retrospective study of 154 patients.
Maahs GS, Oppermann Pde O, Maahs LG, Machado Filho G, Ronchi AD
Braz J Otorhinolaryngol 2015 May-Jun;81(3):301-6. Epub 2015 Mar 30 doi: 10.1016/j.bjorl.2015.03.007. PMID: 25934418Free PMC Article

Diagnosis

Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.
Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Mucoepidermoid carcinoma. An update and review of the literature.
Peraza A, Gómez R, Beltran J, Amarista FJ
J Stomatol Oral Maxillofac Surg 2020 Dec;121(6):713-720. Epub 2020 Jun 18 doi: 10.1016/j.jormas.2020.06.003. PMID: 32565266
Pediatric Salivary Gland Malignancies.
Ord RA, Carlson ER
Oral Maxillofac Surg Clin North Am 2016 Feb;28(1):83-9. doi: 10.1016/j.coms.2015.07.007. PMID: 26614703
Mucoepidermoid carcinoma.
Devaraju R, Gantala R, Aitha H, Gotoor SG
BMJ Case Rep 2014 Aug 1;2014:bcr-2013-202776. doi: 10.1136/bcr-2013-202776. PMID: 25085946Free PMC Article
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Therapy

Machine learning-based survival prediction nomogram for postoperative parotid mucoepidermoid carcinoma.
Huang Z, Chen Z, Li Y, Lin T, Cai S, Wu W, Wu L, Xu S, Lu J, Qiu S
Sci Rep 2024 Apr 1;14(1):7686. doi: 10.1038/s41598-024-58329-8. PMID: 38561379Free PMC Article
Prognosis of Pediatric Patients With Mucoepidermoid Carcinoma of the Parotid Gland.
Li MZ, Mao MH, Feng ZE, Li JZ, Li H, Qin LZ, Li JH, Huang X, Xing RD, Han ZX
J Craniofac Surg 2020 Mar/Apr;31(2):e123-e126. doi: 10.1097/SCS.0000000000006048. PMID: 31764567
RANK and RANK Ligand Expression in Parotid Gland Carcinomas.
Franchi A, Taverna C, Simoni A, Pepi M, Mannelli G, Fasolati M, Gallo O
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):478-482. doi: 10.1097/PAI.0000000000000465. PMID: 29494398
Salivary gland tumors in children: a retrospective clinical review.
Varan A, Akyüz C, Ataş E, Yücel T, Aydın B, Yalçın B, Kutluk T, Büyükpamukçu M
Pediatr Hematol Oncol 2014 Nov;31(8):681-6. Epub 2014 Sep 23 doi: 10.3109/08880018.2014.942936. PMID: 25247345
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116

Prognosis

Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.
Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Clinicopathological Predictors of Survival for Parotid Mucoepidermoid Carcinoma: A Systematic Review.
Cheng EY, Kim JH, Grose EM, Philteos J, Levin M, de Almeida J, Goldstein D
Otolaryngol Head Neck Surg 2023 Apr;168(4):611-618. Epub 2023 Feb 5 doi: 10.1177/01945998221086845. PMID: 35316125
Management and prognosis of cancers in the accessory parotid gland.
Han X, Zhang X, Gao Y, Pang P, Liu F, Sun C
J Int Med Res 2018 Dec;46(12):4930-4933. Epub 2018 Oct 5 doi: 10.1177/0300060518767792. PMID: 30289052Free PMC Article
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Submandibular gland tumors.
Hanna DC, Clairmont AA
Plast Reconstr Surg 1978 Feb;61(2):198-203. doi: 10.1097/00006534-197802000-00007. PMID: 202980

Clinical prediction guides

Machine learning-based survival prediction nomogram for postoperative parotid mucoepidermoid carcinoma.
Huang Z, Chen Z, Li Y, Lin T, Cai S, Wu W, Wu L, Xu S, Lu J, Qiu S
Sci Rep 2024 Apr 1;14(1):7686. doi: 10.1038/s41598-024-58329-8. PMID: 38561379Free PMC Article
Clinicopathological Predictors of Survival for Parotid Mucoepidermoid Carcinoma: A Systematic Review.
Cheng EY, Kim JH, Grose EM, Philteos J, Levin M, de Almeida J, Goldstein D
Otolaryngol Head Neck Surg 2023 Apr;168(4):611-618. Epub 2023 Feb 5 doi: 10.1177/01945998221086845. PMID: 35316125
Mucoepidermoid carcinoma: Evaluating the prognostic impact of primary tumor site.
Mimica X, Yuan A, Hay A, Katabi N, Zanoni DK, Valero C, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2021 Dec;123:105602. Epub 2021 Nov 9 doi: 10.1016/j.oraloncology.2021.105602. PMID: 34768210Free PMC Article
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Clinicopathological features of mucoepidermoid carcinoma.
Yamazaki K, Ohta H, Shodo R, Matsuyama H, Takahashi S
J Laryngol Otol 2014 Jan;128(1):91-5. Epub 2014 Jan 22 doi: 10.1017/S0022215113003459. PMID: 24451647

Recent systematic reviews

Clinicopathological Predictors of Survival for Parotid Mucoepidermoid Carcinoma: A Systematic Review.
Cheng EY, Kim JH, Grose EM, Philteos J, Levin M, de Almeida J, Goldstein D
Otolaryngol Head Neck Surg 2023 Apr;168(4):611-618. Epub 2023 Feb 5 doi: 10.1177/01945998221086845. PMID: 35316125
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Clinicopathological analysis and survival outcomes of primary salivary gland tumors in pediatric patients: A systematic review.
Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME
J Oral Pathol Med 2021 May;50(5):435-443. Epub 2021 Jan 8 doi: 10.1111/jop.13151. PMID: 33314344
Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta-analysis.
Zamani M, Grønhøj C, Schmidt Jensen J, von Buchwald C, Charabi BW, Hjuler T
Pediatr Blood Cancer 2019 Mar;66(3):e27543. Epub 2018 Oct 30 doi: 10.1002/pbc.27543. PMID: 30378272

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