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Major salivary gland carcinoma ex pleomorphic adenoma

MedGen UID:
233655
•Concept ID:
C1334550
•
Neoplastic Process
Synonyms: Carcinoma ex Pleomorphic Adenoma of Major Salivary Gland; carcinoma ex pleomorphic adenoma of Major salivary gland; Carcinoma ex Pleomorphic Adenoma of the Major Salivary Gland; carcinoma ex pleomorphic adenoma of the Major salivary gland; Major Salivary Gland Carcinoma ex Pleomorphic Adenoma; major salivary gland carcinoma ex pleomorphic adenoma; major salivary gland salivary gland carcinoma ex pleomorphic adenoma
 
Monarch Initiative: MONDO:0006285

Definition

A carcinoma that arises from a pleomorphic adenoma in the major salivary glands. It usually originates in the parotid gland. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive. [from NCI]

Professional guidelines

PubMed

Aggressive Salivary Malignancies at Early Stage: Outcomes and Implications for Treatment.
Eppsteiner RW, Fowlkes JW, Anderson CM, Robinson RA, Pagedar NA
Ann Otol Rhinol Laryngol 2017 Jul;126(7):525-529. Epub 2017 May 5 doi: 10.1177/0003489417702655. PMID: 28474964

Recent clinical studies

Etiology

Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.
Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Carcinoma Ex Pleomorphic Adenomas: An Institutional Experience and Literature Review.
Tondi-Resta I, Hobday SB, Gubbiotti MA, Jalaly JB, Rassekh CH, Montone KT, Baloch ZW
Am J Clin Pathol 2023 May 2;159(5):502-515. doi: 10.1093/ajcp/aqac181. PMID: 36921078
Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.
Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
Outcomes of carcinoma ex pleomorphic adenoma compared to de novo adenocarcinoma of major salivary glands.
Patel EJ, Oliver JR, Liu C, Tam M, Givi B
J Surg Oncol 2021 Feb;123(2):446-455. Epub 2020 Nov 4 doi: 10.1002/jso.26289. PMID: 33145786

Diagnosis

Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.
Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Carcinoma Ex Pleomorphic Adenomas: An Institutional Experience and Literature Review.
Tondi-Resta I, Hobday SB, Gubbiotti MA, Jalaly JB, Rassekh CH, Montone KT, Baloch ZW
Am J Clin Pathol 2023 May 2;159(5):502-515. doi: 10.1093/ajcp/aqac181. PMID: 36921078
Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Pleomorphic adenoma: the great mimicker of malignancy.
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Margin Analysis: Malignant Salivary Gland Neoplasms of the Head and Neck.
Ord RA, Ghazali N
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):315-324. Epub 2017 May 24 doi: 10.1016/j.coms.2017.03.008. PMID: 28551337

Therapy

Parotid salivary duct carcinoma: a single institution's 20-year experience.
Stodulski D, Mikaszewski B, Majewska H, Kuczkowski J
Eur Arch Otorhinolaryngol 2019 Jul;276(7):2031-2038. Epub 2019 May 6 doi: 10.1007/s00405-019-05454-0. PMID: 31062093Free PMC Article
The impact of FDG-PET in the management of patients with salivary gland malignancy.
Otsuka H, Graham MM, Kogame M, Nishitani H
Ann Nucl Med 2005 Dec;19(8):691-4. doi: 10.1007/BF02985118. PMID: 16444995

Prognosis

Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.
Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.
Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
Outcomes of carcinoma ex pleomorphic adenoma compared to de novo adenocarcinoma of major salivary glands.
Patel EJ, Oliver JR, Liu C, Tam M, Givi B
J Surg Oncol 2021 Feb;123(2):446-455. Epub 2020 Nov 4 doi: 10.1002/jso.26289. PMID: 33145786
Margin Analysis: Malignant Salivary Gland Neoplasms of the Head and Neck.
Ord RA, Ghazali N
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):315-324. Epub 2017 May 24 doi: 10.1016/j.coms.2017.03.008. PMID: 28551337

Clinical prediction guides

CD24-gold nanocomposite as promising and sensitive biomarker for cancer stem cells in salivary gland tumors.
Farag AF, Hassabou NF
Nanomedicine 2022 Nov;46:102598. Epub 2022 Sep 8 doi: 10.1016/j.nano.2022.102598. PMID: 36089234
Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.
Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
Carcinoma ex pleomorphic adenoma: A review of incidence, demographics, risk factors, and survival.
Gupta A, Koochakzadeh S, Neskey DM, Nguyen SA, Lentsch EJ
Am J Otolaryngol 2019 Nov-Dec;40(6):102279. Epub 2019 Aug 21 doi: 10.1016/j.amjoto.2019.102279. PMID: 31471126
Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.
Xu B, Mneimneh W, Torrence DE, Higgins K, Klimstra D, Ghossein R, Katabi N
Am J Surg Pathol 2019 May;43(5):601-609. doi: 10.1097/PAS.0000000000001218. PMID: 30789358Free PMC Article
Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature.
Kuo YL, Tu TY, Chang CF, Li WY, Chang SY, Shiao AS, Chu PY, Chan KT, Tai SK, Wang YF, Kao SC, Kao SY, Lo WL, Wu CH, Shu WH, Ma S, Wang TH
Eur Arch Otorhinolaryngol 2011 Jul;268(7):1035-40. Epub 2010 Dec 1 doi: 10.1007/s00405-010-1437-2. PMID: 21120660

Recent systematic reviews

Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695

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