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Generalized abnormality of skin

MedGen UID:
866804
•Concept ID:
C4021157
•
Anatomical Abnormality
Synonym: Generalised abnormality of skin
 
HPO: HP:0011354

Definition

An abnormality of the skin that is not localized to any one particular region. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Generalized abnormality of skin

Professional guidelines

PubMed

Skin Pigmentation Types, Causes and Treatment-A Review.
Thawabteh AM, Jibreen A, Karaman D, Thawabteh A, Karaman R
Molecules 2023 Jun 18;28(12) doi: 10.3390/molecules28124839. PMID: 37375394Free PMC Article
Keratosis pilaris: an update and approach to management.
Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753
JAK inhibitors in the treatment of atopic dermatitis.
Chovatiya R, Paller AS
J Allergy Clin Immunol 2021 Oct;148(4):927-940. Epub 2021 Aug 24 doi: 10.1016/j.jaci.2021.08.009. PMID: 34437922Free PMC Article

Recent clinical studies

Etiology

Pediatric joint hypermobility: a diagnostic framework and narrative review.
Tofts LJ, Simmonds J, Schwartz SB, Richheimer RM, O'Connor C, Elias E, Engelbert R, Cleary K, Tinkle BT, Kline AD, Hakim AJ, van Rossum MAJ, Pacey V
Orphanet J Rare Dis 2023 May 4;18(1):104. doi: 10.1186/s13023-023-02717-2. PMID: 37143135Free PMC Article
The Pathogenesis and Management of Acne-Induced Post-inflammatory Hyperpigmentation.
Elbuluk N, Grimes P, Chien A, Hamzavi I, Alexis A, Taylor S, Gonzalez N, Weiss J, Desai SR, Kang S
Am J Clin Dermatol 2021 Nov;22(6):829-836. Epub 2021 Sep 1 doi: 10.1007/s40257-021-00633-4. PMID: 34468934
Tuberous Sclerosis Complex.
Islam MP
Semin Pediatr Neurol 2021 Apr;37:100875. Epub 2021 Feb 11 doi: 10.1016/j.spen.2021.100875. PMID: 33892851
Inherited ichthyosis: Non-syndromic forms.
Takeichi T, Akiyama M
J Dermatol 2016 Mar;43(3):242-51. doi: 10.1111/1346-8138.13243. PMID: 26945532
Ceramides and skin function.
Coderch L, López O, de la Maza A, Parra JL
Am J Clin Dermatol 2003;4(2):107-29. doi: 10.2165/00128071-200304020-00004. PMID: 12553851

Diagnosis

Keratosis pilaris: an update and approach to management.
Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753
Pediatric joint hypermobility: a diagnostic framework and narrative review.
Tofts LJ, Simmonds J, Schwartz SB, Richheimer RM, O'Connor C, Elias E, Engelbert R, Cleary K, Tinkle BT, Kline AD, Hakim AJ, van Rossum MAJ, Pacey V
Orphanet J Rare Dis 2023 May 4;18(1):104. doi: 10.1186/s13023-023-02717-2. PMID: 37143135Free PMC Article
Skin Changes of POEMS.
Liu S, Jiao Y
J Gen Intern Med 2023 Oct;38(13):3065-3066. Epub 2023 Mar 21 doi: 10.1007/s11606-023-08171-x. PMID: 36944904Free PMC Article
Amino acid synthesis deficiencies.
de Koning TJ
J Inherit Metab Dis 2017 Jul;40(4):609-620. Epub 2017 Jun 26 doi: 10.1007/s10545-017-0063-1. PMID: 28653176Free PMC Article
Differential diagnosis and diagnostic flow chart of joint hypermobility syndrome/ehlers-danlos syndrome hypermobility type compared to other heritable connective tissue disorders.
Colombi M, Dordoni C, Chiarelli N, Ritelli M
Am J Med Genet C Semin Med Genet 2015 Mar;169C(1):6-22. doi: 10.1002/ajmg.c.31429. PMID: 25821090

Therapy

Long-Term Benefits of Tagraxofusp for Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm.
Pemmaraju N, Sweet KL, Stein AS, Wang ES, Rizzieri DA, Vasu S, Rosenblat TL, Brooks CL, Habboubi N, Mughal TI, Kantarjian H, Konopleva M, Lane AA
J Clin Oncol 2022 Sep 10;40(26):3032-3036. Epub 2022 Jul 12 doi: 10.1200/JCO.22.00034. PMID: 35820082Free PMC Article
The Pathogenesis and Management of Acne-Induced Post-inflammatory Hyperpigmentation.
Elbuluk N, Grimes P, Chien A, Hamzavi I, Alexis A, Taylor S, Gonzalez N, Weiss J, Desai SR, Kang S
Am J Clin Dermatol 2021 Nov;22(6):829-836. Epub 2021 Sep 1 doi: 10.1007/s40257-021-00633-4. PMID: 34468934
Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers.
He H, Olesen CM, Pavel AB, Clausen ML, Wu J, Estrada Y, Zhang N, Agner T, Guttman-Yassky E
Front Immunol 2020;11:1768. Epub 2020 Aug 6 doi: 10.3389/fimmu.2020.01768. PMID: 32849633Free PMC Article
Tuberous sclerosis complex.
Henske EP, Jóźwiak S, Kingswood JC, Sampson JR, Thiele EA
Nat Rev Dis Primers 2016 May 26;2:16035. doi: 10.1038/nrdp.2016.35. PMID: 27226234
Ceramides and skin function.
Coderch L, López O, de la Maza A, Parra JL
Am J Clin Dermatol 2003;4(2):107-29. doi: 10.2165/00128071-200304020-00004. PMID: 12553851

Prognosis

Blockade of interleukin-13 signalling improves skin barrier function and biology in patients with moderate-to-severe atopic dermatitis.
Sander N, Stölzl D, Fonfara M, Hartmann J, Harder I, Suhrkamp I, Jakaša I, van den Bogaard E, van Vlijmen-Willems I, Szymczak S, Rodriguez E, Gerdes S, Weidinger S
Br J Dermatol 2024 Aug 14;191(3):344-350. doi: 10.1093/bjd/ljae138. PMID: 38531691
Current Concepts on the Pathogenesis of Systemic Sclerosis.
Truchetet ME, Brembilla NC, Chizzolini C
Clin Rev Allergy Immunol 2023 Jun;64(3):262-283. Epub 2021 Sep 6 doi: 10.1007/s12016-021-08889-8. PMID: 34487318Free PMC Article
Inherited epidermolysis bullosa.
Fine JD
Orphanet J Rare Dis 2010 May 28;5:12. doi: 10.1186/1750-1172-5-12. PMID: 20507631Free PMC Article
Treating vascular lesions.
Astner S, Anderson RR
Dermatol Ther 2005 May-Jun;18(3):267-81. doi: 10.1111/j.1529-8019.2005.05025.x. PMID: 16229727
Gardner's syndrome.
Perniciaro C
Dermatol Clin 1995 Jan;13(1):51-6. PMID: 7712650

Clinical prediction guides

Blockade of interleukin-13 signalling improves skin barrier function and biology in patients with moderate-to-severe atopic dermatitis.
Sander N, Stölzl D, Fonfara M, Hartmann J, Harder I, Suhrkamp I, Jakaša I, van den Bogaard E, van Vlijmen-Willems I, Szymczak S, Rodriguez E, Gerdes S, Weidinger S
Br J Dermatol 2024 Aug 14;191(3):344-350. doi: 10.1093/bjd/ljae138. PMID: 38531691
Pediatric joint hypermobility: a diagnostic framework and narrative review.
Tofts LJ, Simmonds J, Schwartz SB, Richheimer RM, O'Connor C, Elias E, Engelbert R, Cleary K, Tinkle BT, Kline AD, Hakim AJ, van Rossum MAJ, Pacey V
Orphanet J Rare Dis 2023 May 4;18(1):104. doi: 10.1186/s13023-023-02717-2. PMID: 37143135Free PMC Article
p63 in corneal and epidermal differentiation.
Novelli F, Ganini C, Melino G, Nucci C, Han Y, Shi Y, Wang Y, Candi E
Biochem Biophys Res Commun 2022 Jun 25;610:15-22. Epub 2022 Apr 9 doi: 10.1016/j.bbrc.2022.04.022. PMID: 35430447
Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers.
He H, Olesen CM, Pavel AB, Clausen ML, Wu J, Estrada Y, Zhang N, Agner T, Guttman-Yassky E
Front Immunol 2020;11:1768. Epub 2020 Aug 6 doi: 10.3389/fimmu.2020.01768. PMID: 32849633Free PMC Article
Amino acid synthesis deficiencies.
de Koning TJ
J Inherit Metab Dis 2017 Jul;40(4):609-620. Epub 2017 Jun 26 doi: 10.1007/s10545-017-0063-1. PMID: 28653176Free PMC Article

Recent systematic reviews

Treatment of enterocutaneous fistula: a systematic review and meta-analysis.
Gefen R, Garoufalia Z, Zhou P, Watson K, Emile SH, Wexner SD
Tech Coloproctol 2022 Nov;26(11):863-874. Epub 2022 Aug 1 doi: 10.1007/s10151-022-02656-3. PMID: 35915291
Strategies for using topical corticosteroids in children and adults with eczema.
Lax SJ, Harvey J, Axon E, Howells L, Santer M, Ridd MJ, Lawton S, Langan S, Roberts A, Ahmed A, Muller I, Ming LC, Panda S, Chernyshov P, Carter B, Williams HC, Thomas KS, Chalmers JR
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013356. doi: 10.1002/14651858.CD013356.pub2. PMID: 35275399Free PMC Article
Brunsting-Perry pemphigoid: a systematic review.
Aromolo IF, Maronese CA, Moltrasio C, Genovese G, Marzano AV
Int J Dermatol 2022 Nov;61(11):1353-1358. Epub 2022 Jan 20 doi: 10.1111/ijd.16045. PMID: 35049061
Airway Ultrasound as Predictor of Difficult Direct Laryngoscopy: A Systematic Review and Meta-analysis.
Carsetti A, Sorbello M, Adrario E, Donati A, Falcetta S
Anesth Analg 2022 Apr 1;134(4):740-750. doi: 10.1213/ANE.0000000000005839. PMID: 34914641Free PMC Article
Association between smoking and hand dermatitis--a systematic review and meta-analysis.
Lukács J, Schliemann S, Elsner P
J Eur Acad Dermatol Venereol 2015 Jul;29(7):1280-4. Epub 2015 Feb 4 doi: 10.1111/jdv.12971. PMID: 25650777

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