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Bone Diseases, Infectious

MedGen UID:
630
•Concept ID:
C0005943
•
Disease or Syndrome
Synonyms: Bone Disease, Infectious; Disease, Infectious Bone; Diseases, Infectious Bone; Infectious Bone Disease; Infectious Bone Diseases

Definition

Bone diseases caused by pathogenic microorganisms. [from MeSH]

Professional guidelines

PubMed

In vitro/in vivo comparison of cefuroxime release from poly(ε-caprolactone)-calcium sulfate implants for osteomyelitis treatment.
Yaprakci V, Erdemli O, Kayabolen A, Tezcaner A, Bozkurt F, Keskin D
Biotechnol Appl Biochem 2013 Nov-Dec;60(6):603-16. Epub 2013 Aug 26 doi: 10.1002/bab.1118. PMID: 23586705

Recent clinical studies

Etiology

Musculoskeletal infections through direct inoculation.
Sabir N, Akkaya Z
Skeletal Radiol 2024 Oct;53(10):2161-2179. Epub 2024 Jan 30 doi: 10.1007/s00256-024-04591-w. PMID: 38291151Free PMC Article
Oral versus intravenous antibiotics for bone and joint infections: the OVIVA non-inferiority RCT.
Scarborough M, Li HK, Rombach I, Zambellas R, Walker AS, McNally M, Atkins B, Kümin M, Lipsky BA, Hughes H, Bose D, Warren S, Mack D, Folb J, Moore E, Jenkins N, Hopkins S, Seaton RA, Hemsley C, Sandoe J, Aggarwal I, Ellis S, Sutherland R, Geue C, McMeekin N, Scarborough C, Paul J, Cooke G, Bostock J, Khatamzas E, Wong N, Brent A, Lomas J, Matthews P, Wangrangsimakul T, Gundle R, Rogers M, Taylor A, Thwaites GE, Bejon P
Health Technol Assess 2019 Aug;23(38):1-92. doi: 10.3310/hta23380. PMID: 31373271Free PMC Article
Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Li HK, Rombach I, Zambellas R, Walker AS, McNally MA, Atkins BL, Lipsky BA, Hughes HC, Bose D, Kümin M, Scarborough C, Matthews PC, Brent AJ, Lomas J, Gundle R, Rogers M, Taylor A, Angus B, Byren I, Berendt AR, Warren S, Fitzgerald FE, Mack DJF, Hopkins S, Folb J, Reynolds HE, Moore E, Marshall J, Jenkins N, Moran CE, Woodhouse AF, Stafford S, Seaton RA, Vallance C, Hemsley CJ, Bisnauthsing K, Sandoe JAT, Aggarwal I, Ellis SC, Bunn DJ, Sutherland RK, Barlow G, Cooper C, Geue C, McMeekin N, Briggs AH, Sendi P, Khatamzas E, Wangrangsimakul T, Wong THN, Barrett LK, Alvand A, Old CF, Bostock J, Paul J, Cooke G, Thwaites GE, Bejon P, Scarborough M; OVIVA Trial Collaborators
N Engl J Med 2019 Jan 31;380(5):425-436. doi: 10.1056/NEJMoa1710926. PMID: 30699315Free PMC Article
Mycobacterial Musculoskeletal Infections.
Hogan JI, Hurtado RM, Nelson SB
Thorac Surg Clin 2019 Feb;29(1):85-94. doi: 10.1016/j.thorsurg.2018.09.007. PMID: 30454925
Spinal infections.
Tay BK, Deckey J, Hu SS
J Am Acad Orthop Surg 2002 May-Jun;10(3):188-97. doi: 10.5435/00124635-200205000-00005. PMID: 12041940

Diagnosis

Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Li HK, Rombach I, Zambellas R, Walker AS, McNally MA, Atkins BL, Lipsky BA, Hughes HC, Bose D, Kümin M, Scarborough C, Matthews PC, Brent AJ, Lomas J, Gundle R, Rogers M, Taylor A, Angus B, Byren I, Berendt AR, Warren S, Fitzgerald FE, Mack DJF, Hopkins S, Folb J, Reynolds HE, Moore E, Marshall J, Jenkins N, Moran CE, Woodhouse AF, Stafford S, Seaton RA, Vallance C, Hemsley CJ, Bisnauthsing K, Sandoe JAT, Aggarwal I, Ellis SC, Bunn DJ, Sutherland RK, Barlow G, Cooper C, Geue C, McMeekin N, Briggs AH, Sendi P, Khatamzas E, Wangrangsimakul T, Wong THN, Barrett LK, Alvand A, Old CF, Bostock J, Paul J, Cooke G, Thwaites GE, Bejon P, Scarborough M; OVIVA Trial Collaborators
N Engl J Med 2019 Jan 31;380(5):425-436. doi: 10.1056/NEJMoa1710926. PMID: 30699315Free PMC Article
Mycobacterial Musculoskeletal Infections.
Hogan JI, Hurtado RM, Nelson SB
Thorac Surg Clin 2019 Feb;29(1):85-94. doi: 10.1016/j.thorsurg.2018.09.007. PMID: 30454925
Red flags presented in current low back pain guidelines: a review.
Verhagen AP, Downie A, Popal N, Maher C, Koes BW
Eur Spine J 2016 Sep;25(9):2788-802. Epub 2016 Jul 4 doi: 10.1007/s00586-016-4684-0. PMID: 27376890
Molecular diagnostics.
Choe H, Deirmengian CA, Hickok NJ, Morrison TN, Tuan RS
J Am Acad Orthop Surg 2015 Apr;23 Suppl(0):S26-31. doi: 10.5435/JAAOS-D-14-00409. PMID: 25808967Free PMC Article
Spinal infections.
Tay BK, Deckey J, Hu SS
J Am Acad Orthop Surg 2002 May-Jun;10(3):188-97. doi: 10.5435/00124635-200205000-00005. PMID: 12041940

Therapy

Bacteriophage therapy for bone and joint infections.
Gibb BP, Hadjiargyrou M
Bone Joint J 2021 Feb;103-B(2):234-244. doi: 10.1302/0301-620X.103B2.BJJ-2020-0452.R2. PMID: 33517726Free PMC Article
Oral versus intravenous antibiotics for bone and joint infections: the OVIVA non-inferiority RCT.
Scarborough M, Li HK, Rombach I, Zambellas R, Walker AS, McNally M, Atkins B, Kümin M, Lipsky BA, Hughes H, Bose D, Warren S, Mack D, Folb J, Moore E, Jenkins N, Hopkins S, Seaton RA, Hemsley C, Sandoe J, Aggarwal I, Ellis S, Sutherland R, Geue C, McMeekin N, Scarborough C, Paul J, Cooke G, Bostock J, Khatamzas E, Wong N, Brent A, Lomas J, Matthews P, Wangrangsimakul T, Gundle R, Rogers M, Taylor A, Thwaites GE, Bejon P
Health Technol Assess 2019 Aug;23(38):1-92. doi: 10.3310/hta23380. PMID: 31373271Free PMC Article
The role of fosfomycin in osteoarticular infection.
Morata L, Soriano A
Rev Esp Quimioter 2019 May;32 Suppl 1(Suppl 1):30-36. PMID: 31131590Free PMC Article
Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Li HK, Rombach I, Zambellas R, Walker AS, McNally MA, Atkins BL, Lipsky BA, Hughes HC, Bose D, Kümin M, Scarborough C, Matthews PC, Brent AJ, Lomas J, Gundle R, Rogers M, Taylor A, Angus B, Byren I, Berendt AR, Warren S, Fitzgerald FE, Mack DJF, Hopkins S, Folb J, Reynolds HE, Moore E, Marshall J, Jenkins N, Moran CE, Woodhouse AF, Stafford S, Seaton RA, Vallance C, Hemsley CJ, Bisnauthsing K, Sandoe JAT, Aggarwal I, Ellis SC, Bunn DJ, Sutherland RK, Barlow G, Cooper C, Geue C, McMeekin N, Briggs AH, Sendi P, Khatamzas E, Wangrangsimakul T, Wong THN, Barrett LK, Alvand A, Old CF, Bostock J, Paul J, Cooke G, Thwaites GE, Bejon P, Scarborough M; OVIVA Trial Collaborators
N Engl J Med 2019 Jan 31;380(5):425-436. doi: 10.1056/NEJMoa1710926. PMID: 30699315Free PMC Article
Dimorphic fungal osteoarticular infections.
Rammaert B, Gamaletsou MN, Zeller V, Elie C, Prinapori R, Taj-Aldeen SJ, Roilides E, Kontoyiannis DP, Brause B, Sipsas NV, Walsh TJ, Lortholary O
Eur J Clin Microbiol Infect Dis 2014 Dec;33(12):2131-40. Epub 2014 Jun 18 doi: 10.1007/s10096-014-2149-0. PMID: 24939620

Prognosis

Oral versus intravenous antibiotics for bone and joint infections: the OVIVA non-inferiority RCT.
Scarborough M, Li HK, Rombach I, Zambellas R, Walker AS, McNally M, Atkins B, Kümin M, Lipsky BA, Hughes H, Bose D, Warren S, Mack D, Folb J, Moore E, Jenkins N, Hopkins S, Seaton RA, Hemsley C, Sandoe J, Aggarwal I, Ellis S, Sutherland R, Geue C, McMeekin N, Scarborough C, Paul J, Cooke G, Bostock J, Khatamzas E, Wong N, Brent A, Lomas J, Matthews P, Wangrangsimakul T, Gundle R, Rogers M, Taylor A, Thwaites GE, Bejon P
Health Technol Assess 2019 Aug;23(38):1-92. doi: 10.3310/hta23380. PMID: 31373271Free PMC Article
Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Li HK, Rombach I, Zambellas R, Walker AS, McNally MA, Atkins BL, Lipsky BA, Hughes HC, Bose D, Kümin M, Scarborough C, Matthews PC, Brent AJ, Lomas J, Gundle R, Rogers M, Taylor A, Angus B, Byren I, Berendt AR, Warren S, Fitzgerald FE, Mack DJF, Hopkins S, Folb J, Reynolds HE, Moore E, Marshall J, Jenkins N, Moran CE, Woodhouse AF, Stafford S, Seaton RA, Vallance C, Hemsley CJ, Bisnauthsing K, Sandoe JAT, Aggarwal I, Ellis SC, Bunn DJ, Sutherland RK, Barlow G, Cooper C, Geue C, McMeekin N, Briggs AH, Sendi P, Khatamzas E, Wangrangsimakul T, Wong THN, Barrett LK, Alvand A, Old CF, Bostock J, Paul J, Cooke G, Thwaites GE, Bejon P, Scarborough M; OVIVA Trial Collaborators
N Engl J Med 2019 Jan 31;380(5):425-436. doi: 10.1056/NEJMoa1710926. PMID: 30699315Free PMC Article
Red flags presented in current low back pain guidelines: a review.
Verhagen AP, Downie A, Popal N, Maher C, Koes BW
Eur Spine J 2016 Sep;25(9):2788-802. Epub 2016 Jul 4 doi: 10.1007/s00586-016-4684-0. PMID: 27376890
Nontuberculous mycobacterial infections.
Jarzembowski JA, Young MB
Arch Pathol Lab Med 2008 Aug;132(8):1333-41. doi: 10.5858/2008-132-1333-NMI. PMID: 18684037
Osseous hydatid disease.
Papanikolaou A
Trans R Soc Trop Med Hyg 2008 Mar;102(3):233-8. Epub 2007 Nov 9 doi: 10.1016/j.trstmh.2007.09.012. PMID: 17996916

Clinical prediction guides

Osteoarticular infection in children.
Coulin B, Demarco G, Spyropoulou V, Juchler C, Vendeuvre T, Habre C, Tabard-Fougère A, Dayer R, Steiger C, Ceroni D
Bone Joint J 2021 Mar;103-B(3):578-583. doi: 10.1302/0301-620X.103B3.BJJ-2020-0936.R2. PMID: 33641416
Red flags presented in current low back pain guidelines: a review.
Verhagen AP, Downie A, Popal N, Maher C, Koes BW
Eur Spine J 2016 Sep;25(9):2788-802. Epub 2016 Jul 4 doi: 10.1007/s00586-016-4684-0. PMID: 27376890
Sequelae of pediatric osteoarticular infection.
Ilharreborde B
Orthop Traumatol Surg Res 2015 Feb;101(1 Suppl):S129-37. Epub 2014 Dec 29 doi: 10.1016/j.otsr.2014.07.029. PMID: 25553604
Dimorphic fungal osteoarticular infections.
Rammaert B, Gamaletsou MN, Zeller V, Elie C, Prinapori R, Taj-Aldeen SJ, Roilides E, Kontoyiannis DP, Brause B, Sipsas NV, Walsh TJ, Lortholary O
Eur J Clin Microbiol Infect Dis 2014 Dec;33(12):2131-40. Epub 2014 Jun 18 doi: 10.1007/s10096-014-2149-0. PMID: 24939620
Pediatric bone scintigraphy update.
Nadel HR
Semin Nucl Med 2010 Jan;40(1):31-40. doi: 10.1053/j.semnuclmed.2009.10.001. PMID: 19958848

Recent systematic reviews

A Systematic Review and Meta-Analysis of Combined Antibiotic Spacer with Ilizarov Methods in the Treatment of Infected Nonunion of Tibia.
Deng Z, Mu Y, Sun X, Xu Y, Li F, Yin L
Biomed Res Int 2021;2021:6668617. Epub 2021 Jan 16 doi: 10.1155/2021/6668617. PMID: 33532493Free PMC Article
Sphingomonas paucimobilis-related bone and soft-tissue infections: A systematic review.
El Beaino M, Fares J, Malek A, Hachem R
Int J Infect Dis 2018 Dec;77:68-73. Epub 2018 Sep 26 doi: 10.1016/j.ijid.2018.09.021. PMID: 30267938
Minimally invasive spine surgery in spinal infections.
Verdú-López F, Vanaclocha-Vanaclocha V, Mayorga-Villa JD
J Neurosurg Sci 2017 Jun;61(3):303-315. Epub 2016 Oct 27 doi: 10.23736/S0390-5616.16.03911-4. PMID: 27787487
Incidence, characteristics, and outcomes of patients with bone and joint infections due to community-associated methicillin-resistant Staphylococcus aureus: a systematic review.
Vardakas KZ, Kontopidis I, Gkegkes ID, Rafailidis PI, Falagas ME
Eur J Clin Microbiol Infect Dis 2013 Jun;32(6):711-21. Epub 2013 Jan 20 doi: 10.1007/s10096-012-1807-3. PMID: 23334662
Daptomycin for treatment of patients with bone and joint infections: a systematic review of the clinical evidence.
Falagas ME, Giannopoulou KP, Ntziora F, Papagelopoulos PJ
Int J Antimicrob Agents 2007 Sep;30(3):202-9. Epub 2007 Apr 24 doi: 10.1016/j.ijantimicag.2007.02.012. PMID: 17459668

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