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Rectosigmoid Signet Ring Cell Carcinoma

MedGen UID:
311208
•Concept ID:
C1709869
•
Neoplastic Process
Synonym: Rectosigmoid Signet-Ring Cell Carcinoma

Definition

An infiltrating adenocarcinoma arising from the rectosigmoid area. It is characterized by the presence of malignant glandular cells with prominent intracytoplasmic mucin. These cells constitute more than 50% of the malignant cellular population. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectosigmoid Signet Ring Cell Carcinoma

Recent clinical studies

Etiology

Prevalence of Regional Lymph Node Metastasis of Mucosal Gastric Signet Ring Cell Carcinoma: Analysis of the Collaborative Stage Data Survey of the Korean Central Cancer Registry.
Jeong SH, Kim JW, Kim HM
Dig Surg 2021;38(5-6):330-336. Epub 2021 Sep 14 doi: 10.1159/000518898. PMID: 34521093
Clinical, endoscopic and histological profile of colorectal cancers seen on colonoscopy in Kano, North-Western Nigeria.
Musa Y, Mohammed MF, Muhammad NO, Yusuf I, Abdulrahim AO, Samaila AA, Borodo MM
Niger Postgrad Med J 2021 Jan-Mar;28(1):22-26. doi: 10.4103/npmj.npmj_288_20. PMID: 33642320
Different clinical characteristics in sporadic young-age onset colorectal cancer.
Lee J, Kim IH, Kim JS, Kim SW, Kim JG, Oh ST, Kang WK, Lee MA
Medicine (Baltimore) 2016 Sep;95(37):e4840. doi: 10.1097/MD.0000000000004840. PMID: 27631240Free PMC Article
Colorectal carcinoma in first decade of life: our experience.
Rahman MA, Chowdhury TK, Bhuiyan MA, Al Farooq MA, Sajid MM, Banu T
Pediatr Surg Int 2014 Aug;30(8):847-51. Epub 2014 Jul 9 doi: 10.1007/s00383-014-3537-3. PMID: 25005910
Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: a histopathological review.
Abdulkareem FB, Abudu EK, Awolola NA, Elesha SO, Rotimi O, Akinde OR, Atoyebi AO, Adesanya AA, Daramola AO, Banjo AA, Anunobi CC
World J Gastroenterol 2008 Nov 14;14(42):6531-5. doi: 10.3748/wjg.14.6531. PMID: 19030207Free PMC Article

Diagnosis

Prevalence of Regional Lymph Node Metastasis of Mucosal Gastric Signet Ring Cell Carcinoma: Analysis of the Collaborative Stage Data Survey of the Korean Central Cancer Registry.
Jeong SH, Kim JW, Kim HM
Dig Surg 2021;38(5-6):330-336. Epub 2021 Sep 14 doi: 10.1159/000518898. PMID: 34521093
Clinical, endoscopic and histological profile of colorectal cancers seen on colonoscopy in Kano, North-Western Nigeria.
Musa Y, Mohammed MF, Muhammad NO, Yusuf I, Abdulrahim AO, Samaila AA, Borodo MM
Niger Postgrad Med J 2021 Jan-Mar;28(1):22-26. doi: 10.4103/npmj.npmj_288_20. PMID: 33642320
Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative colitis-associated high-grade dysplasia.
Sugimoto S, Shimoda M, Iwao Y, Mutaguchi M, Nanki K, Mizuno S, Kameyama K, Ogata H, Naganuma M, Kanai T
Dig Endosc 2019 Nov;31(6):706-711. Epub 2019 Aug 22 doi: 10.1111/den.13482. PMID: 31278777
Primary rectal signet ring cell carcinoma with peritoneal dissemination and gastric secondaries.
Sim HL, Tan KY, Poon PL, Cheng A
World J Gastroenterol 2008 Apr 7;14(13):2118-20. doi: 10.3748/wjg.14.2118. PMID: 18395918Free PMC Article
Primary signet-ring cell carcinoma mimicking segmental Crohn's colitis.
Achneck HE, Pradhan SK, Kavic SM, Longo WE
Dig Liver Dis 2005 Jul;37(7):537-41. Epub 2005 Apr 8 doi: 10.1016/j.dld.2004.12.015. PMID: 15975543

Therapy

Metastatic paediatric colorectal carcinoma.
Woods R, Larkin JO, Muldoon C, Kennedy MJ, Mehigan B, McCormick P
Ir Med J 2012 Mar;105(3):88-9. PMID: 22558819

Prognosis

Prognostic impact of tumor location in stage IV colon cancer: a propensity score analysis in a multicenter study.
Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kanazawa T, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Hashiguchi Y, Sugihara K, Watanabe T
Int J Surg 2014;12(9):925-30. Epub 2014 Aug 1 doi: 10.1016/j.ijsu.2014.07.270. PMID: 25091400
Colorectal carcinoma in first decade of life: our experience.
Rahman MA, Chowdhury TK, Bhuiyan MA, Al Farooq MA, Sajid MM, Banu T
Pediatr Surg Int 2014 Aug;30(8):847-51. Epub 2014 Jul 9 doi: 10.1007/s00383-014-3537-3. PMID: 25005910
Clinicopathological patterns and challenges of management of colorectal cancer in a resource-limited setting: a Tanzanian experience.
Chalya PL, McHembe MD, Mabula JB, Rambau PF, Jaka H, Koy M, Mkongo E, Masalu N
World J Surg Oncol 2013 Apr 18;11:88. doi: 10.1186/1477-7819-11-88. PMID: 23597032Free PMC Article
Different patterns of lymphatic spread of sigmoid, rectosigmoid, and rectal cancers.
Park IJ, Choi GS, Lim KH, Kang BM, Jun SH
Ann Surg Oncol 2008 Dec;15(12):3478-83. Epub 2008 Oct 1 doi: 10.1245/s10434-008-0158-x. PMID: 18830668
Primary signet-ring cell carcinoma mimicking segmental Crohn's colitis.
Achneck HE, Pradhan SK, Kavic SM, Longo WE
Dig Liver Dis 2005 Jul;37(7):537-41. Epub 2005 Apr 8 doi: 10.1016/j.dld.2004.12.015. PMID: 15975543

Clinical prediction guides

Prevalence of Regional Lymph Node Metastasis of Mucosal Gastric Signet Ring Cell Carcinoma: Analysis of the Collaborative Stage Data Survey of the Korean Central Cancer Registry.
Jeong SH, Kim JW, Kim HM
Dig Surg 2021;38(5-6):330-336. Epub 2021 Sep 14 doi: 10.1159/000518898. PMID: 34521093
Clinico-pathological profile of colorectal cancer in first two decades of life: A retrospective analysis from tertiary health center.
Sharma D, Singh G
Indian J Cancer 2017 Apr-Jun;54(2):397-400. doi: 10.4103/ijc.IJC_225_17. PMID: 29469066
Different clinical characteristics in sporadic young-age onset colorectal cancer.
Lee J, Kim IH, Kim JS, Kim SW, Kim JG, Oh ST, Kang WK, Lee MA
Medicine (Baltimore) 2016 Sep;95(37):e4840. doi: 10.1097/MD.0000000000004840. PMID: 27631240Free PMC Article
Prognostic impact of tumor location in stage IV colon cancer: a propensity score analysis in a multicenter study.
Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kanazawa T, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Hashiguchi Y, Sugihara K, Watanabe T
Int J Surg 2014;12(9):925-30. Epub 2014 Aug 1 doi: 10.1016/j.ijsu.2014.07.270. PMID: 25091400

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