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Colon signet ring cell adenocarcinoma

MedGen UID:
313039
•Concept ID:
C1707436
•
Neoplastic Process
Synonyms: colon signet ring adenocarcinoma; Colon Signet Ring Cell Adenocarcinoma; colon signet ring cell adenocarcinoma; colon signet Ring cell adenocarcinoma; Colon Signet-Ring Cell Adenocarcinoma; colonic signet Ring adenocarcinoma; Colonic Signet Ring Cell Adenocarcinoma; colonic signet Ring cell adenocarcinoma; Signet Ring Cell Adenocarcinoma of Colon; signet Ring cell adenocarcinoma of colon; Signet Ring Cell Adenocarcinoma of the Colon; signet Ring cell adenocarcinoma of the colon; Signet Ring Cell Colon Adenocarcinoma; signet Ring cell colon adenocarcinoma
 
Monarch Initiative: MONDO:0002495

Definition

An invasive adenocarcinoma of the colon characterized by the presence of malignant glandular epithelial cells which contain prominent intracytoplasmic mucin (signet ring cells). The signet ring cells constitute more than 50% of the malignant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon signet ring cell adenocarcinoma

Professional guidelines

PubMed

Treatment outcomes of patients with involved resection margin after rectal cancer surgery: A nationwide population-based cohort study in South Korea.
Bong JW, Lee JA, Ju Y, Seo J, Kang SH, Lee SI, Min BW
Asia Pac J Clin Oncol 2022 Aug;18(4):378-387. Epub 2021 Jul 26 doi: 10.1111/ajco.13608. PMID: 34310853
Novel Criteria for Intratumoral Budding with Prognostic Relevance for Colon Cancer and Its Histological Subtypes.
Pour Farid P, Eckstein M, Merkel S, Grützmann R, Hartmann A, Bruns V, Benz M, Schneider-Stock R, Geppert CI
Int J Mol Sci 2021 Dec 3;22(23) doi: 10.3390/ijms222313108. PMID: 34884913Free PMC Article
Signet ring cell carcinoma of the gastrointestinal tract: National trends on treatment effects and prognostic outcomes.
Franko J, Le VH, Tee MC, Lin M, Sedinkin J, Raman S, Frankova D
Cancer Treat Res Commun 2021;29:100475. Epub 2021 Oct 11 doi: 10.1016/j.ctarc.2021.100475. PMID: 34655861

Recent clinical studies

Etiology

A rare cause of intestinal obstruction in children: signet-ring cell adenocarcinoma of the colon.
Erginel B, Mustafayeva N, Karadağ ÇA, Yanar F, Kebudi R, Tanyildiz HG, Tugcu D, Berker N, Ilhan B, Gün Soysal F
Ulus Travma Acil Cerrahi Derg 2023 Jul;29(7):798-805. doi: 10.14744/tjtes.2023.64257. PMID: 37409928Free PMC Article
Characteristics of primary signet ring cell carcinoma of colon and rectum: a case control study.
Weng MT, Chao KH, Tung CC, Chang HC, Shih IL, Lin BR, Shieh MJ, Shun CT, Wong JM, Wei SC
BMC Gastroenterol 2022 Apr 8;22(1):173. doi: 10.1186/s12876-022-02258-1. PMID: 35395754Free PMC Article
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Clinicopathologic and Molecular Features of Colorectal Adenocarcinoma with Signet-Ring Cell Component.
Wei Q, Wang X, Gao J, Li J, Li J, Qi C, Li Y, Li Z, Shen L
PLoS One 2016;11(6):e0156659. Epub 2016 Jun 14 doi: 10.1371/journal.pone.0156659. PMID: 27300552Free PMC Article
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Diagnosis

Characteristics of primary signet ring cell carcinoma of colon and rectum: a case control study.
Weng MT, Chao KH, Tung CC, Chang HC, Shih IL, Lin BR, Shieh MJ, Shun CT, Wong JM, Wei SC
BMC Gastroenterol 2022 Apr 8;22(1):173. doi: 10.1186/s12876-022-02258-1. PMID: 35395754Free PMC Article
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Signet ring cell component predicts aggressive behaviour in colorectal mucinous adenocarcinoma.
Song IH, Hong SM, Yu E, Yoon YS, Park IJ, Lim SB, Kim JC, Yu CS, Kim J
Pathology 2019 Jun;51(4):384-391. Epub 2019 Apr 24 doi: 10.1016/j.pathol.2019.03.001. PMID: 31029443
Imaging in secondary tumors of the ovary.
Karaosmanoglu AD, Onur MR, Salman MC, Usubutun A, Karcaaltincaba M, Ozmen MN, Akata D
Abdom Radiol (NY) 2019 Apr;44(4):1493-1505. doi: 10.1007/s00261-018-1809-4. PMID: 30361868
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Therapy

Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Signet ring cell carcinoma of the rectum: atypical metastatic presentation.
Morales-Cruz M, Salgado-Nesme N, Trolle-Silva AM, Rodríguez-Quintero JH
BMJ Case Rep 2019 Apr 30;12(4) doi: 10.1136/bcr-2018-229135. PMID: 31040144Free PMC Article
Metastatic Signet-Ring Cell Carcinoma of the Skin.
Chrysanthos NV, Nezi V, Zafiropoulou R, Papatheodoridis G, Manesis E
Am J Gastroenterol 2018 Oct;113(10):1427. doi: 10.1038/s41395-018-0099-3. PMID: 29891852
Colorectal signet-ring cell carcinoma: benefit from adjuvant chemotherapy but a poor prognostic factor.
Hugen N, Verhoeven RH, Lemmens VE, van Aart CJ, Elferink MA, Radema SA, Nagtegaal ID, de Wilt JH
Int J Cancer 2015 Jan 15;136(2):333-9. Epub 2014 May 28 doi: 10.1002/ijc.28981. PMID: 24841868
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Prognosis

Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Patient Selection for Cytoreductive Surgery.
Grotz TE, Fournier KF, Mansfield PF
Surg Oncol Clin N Am 2018 Jul;27(3):443-462. doi: 10.1016/j.soc.2018.02.012. PMID: 29935682
Primary signet ring cell carcinoma of the colon and rectum.
Arifi S, Elmesbahi O, Amarti Riffi A
Bull Cancer 2015 Oct;102(10):880-8. Epub 2015 Sep 26 doi: 10.1016/j.bulcan.2015.07.005. PMID: 26412710
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Clinical prediction guides

Perirenal Infiltration of Signet Ring Cell Colon Carcinoma Shown by 68Ga-FAPI PET/CT.
Güzel Y, Kaplan İ, Kepenek F, Söğütçü N, Kömek H
Clin Nucl Med 2022 Jul 1;47(7):e509-e512. Epub 2022 Apr 5 doi: 10.1097/RLU.0000000000004166. PMID: 35675142
Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Signet ring cell component predicts aggressive behaviour in colorectal mucinous adenocarcinoma.
Song IH, Hong SM, Yu E, Yoon YS, Park IJ, Lim SB, Kim JC, Yu CS, Kim J
Pathology 2019 Jun;51(4):384-391. Epub 2019 Apr 24 doi: 10.1016/j.pathol.2019.03.001. PMID: 31029443
Patient Selection for Cytoreductive Surgery.
Grotz TE, Fournier KF, Mansfield PF
Surg Oncol Clin N Am 2018 Jul;27(3):443-462. doi: 10.1016/j.soc.2018.02.012. PMID: 29935682
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Recent systematic reviews

Overall Survival in Phase 3 Clinical Trials and the Surveillance, Epidemiology, and End Results Database in Patients With Metastatic Colorectal Cancer, 1986-2016: A Systematic Review.
Shen C, Tannenbaum D, Horn R, Rogers J, Eng C, Zhou S, Johnson B, Kopetz S, Morris V, Overman M, Parseghian C, Chang GJ, Lopez-Olivo MA, Kanwal R, Ellis LM, Dasari A
JAMA Netw Open 2022 May 2;5(5):e2213588. doi: 10.1001/jamanetworkopen.2022.13588. PMID: 35608860Free PMC Article
Clinics and pathology of Krukenberg tumor: a systematic review and meta-analysis.
Lionetti R, DE Luca M, Raffone A, Travaglino A, Coppellotti A, Peltrini R, Bracale U, D'Ambra M, Insabato L, Zullo F, D'Armiento M, Corcione F
Minerva Obstet Gynecol 2022 Aug;74(4):356-363. Epub 2021 May 4 doi: 10.23736/S2724-606X.21.04797-7. PMID: 33944524
Feto-maternal outcomes of pregnancy complicated by Krukenberg tumor: a systematic review of literature.
Kodama M, Moeini A, Machida H, Blake EA, Grubbs BH, Matsuo K
Arch Gynecol Obstet 2016 Sep;294(3):589-98. Epub 2016 Feb 20 doi: 10.1007/s00404-016-4048-3. PMID: 26897498
Fifty-three years of reporting colorectal cancer in Nigerians--a systematic review of the published literature.
Rotimi O, Abdulkareem FB
Niger Postgrad Med J 2014 Mar;21(1):68-73. PMID: 24956622

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