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Appendix adenoma

MedGen UID:
312900
•Concept ID:
C1706829
•
Neoplastic Process
Synonyms: Appendix Adenoma; appendix adenoma; vermiform appendix adenoma
 
Monarch Initiative: MONDO:0006088

Definition

A circumscribed neoplasm arising from the glandular epithelium of the appendix. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and it is associated with dysplasia. According to the growth pattern, it may be classified as tubular, villous, or tubulovillous. The dysplasia is classified as mild, moderate, or severe. [from NCI]

Professional guidelines

PubMed

Combined Endoscopic Mucosal Resection and Extended Laparoscopic Appendectomy for the Treatment of Periappendiceal, Cecal, and Appendiceal Adenomas.
Huang ES, Chumfong IT, Alkoraishi AS, Munroe CA
J Surg Res 2020 Aug;252:89-95. Epub 2020 Apr 8 doi: 10.1016/j.jss.2020.02.006. PMID: 32278221
The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.
Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986
Diagnosis and management of pediatric endocrine neoplasms.
Iqbal CW, Wahoff DC
Curr Opin Pediatr 2009 Jun;21(3):379-85. doi: 10.1097/MOP.0b013e32832b335e. PMID: 19421059

Recent clinical studies

Therapy

Neoplasms of the Appendix.
Köhler F, Matthes N, Rosenfeldt M, Kunzmann V, Germer CT, Wiegering A
Dtsch Arztebl Int 2023 Aug 7;120(31-32):519-525. doi: 10.3238/arztebl.m2023.0136. PMID: 37282595Free PMC Article
Acute appendicitis after colorectal endoscopic mucosal resection: a case report.
Liu Y, Wang H, Yin XY, Wang T, Liu J, Wu L, Hu LH, Wang FY
J Int Med Res 2022 May;50(5):3000605221096273. doi: 10.1177/03000605221096273. PMID: 35574813Free PMC Article
Postoperative Complications Independently Predict Cancer-Related Survival in Peritoneal Malignancies.
Choudry MHA, Shuai Y, Jones HL, Pai RK, Pingpank JF, Ahrendt SS, Holtzman MP, Zeh HJ, Bartlett DL
Ann Surg Oncol 2018 Dec;25(13):3950-3959. Epub 2018 Oct 9 doi: 10.1245/s10434-018-6823-9. PMID: 30302637
Pseudomyxoma peritonei syndrome of appendiceal origin: an overview.
Brueggen C, Baird G, Meisheid A
Clin J Oncol Nurs 2007 Aug;11(4):525-32. doi: 10.1188/07.CJON.525-532. PMID: 17723965
Pseudomyxoma peritonei.
Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

Prognosis

A practical guide to serrated appendiceal lesions.
Requena DO, Yantiss RK
Semin Diagn Pathol 2024 Sep;41(5):243-249. Epub 2024 Jul 10 doi: 10.1053/j.semdp.2024.07.001. PMID: 39084918
Gastrointestinal Malakoplakia: Clinicopathologic Analysis of 26 Cases.
Zhang Y, Byrnes K, Lam-Himlin D, Pittman M, Pezhouh M, Gonzalez RS, Alruwaii Z, Larman T, Miller JA, Matoso A, Oshima K, Epstein JI, Montgomery EA, Voltaggio L
Am J Surg Pathol 2020 Sep;44(9):1251-1258. doi: 10.1097/PAS.0000000000001491. PMID: 32301754
Mucocoele and mucinous tumours of the appendix: A review of the literature.
Rymer B, Forsythe RO, Husada G
Int J Surg 2015 Jun;18:132-5. Epub 2015 Apr 24 doi: 10.1016/j.ijsu.2015.04.052. PMID: 25917270
Pseudomyxoma peritonei.
Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010
Pseudomyxoma peritonei.
Sugarbaker PH
Cancer Treat Res 1996;81:105-19. doi: 10.1007/978-1-4613-1245-1_10. PMID: 8834579

Clinical prediction guides

Clinical characteristics of appendiceal diverticular disease.
Çakar E, Bayrak S, Çolak Ş, Dal F, Gürbulak B, Bektaş H, Yarıkkaya E, Ferlengez AG
Int J Colorectal Dis 2019 Dec;34(12):2035-2041. Epub 2019 Nov 4 doi: 10.1007/s00384-019-03410-2. PMID: 31686198
If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies.
Ma KW, Chia NH, Yeung HW, Cheung MT
Hong Kong Med J 2010 Feb;16(1):12-7. PMID: 20124568
Pseudomyxoma peritonei syndrome of appendiceal origin: an overview.
Brueggen C, Baird G, Meisheid A
Clin J Oncol Nurs 2007 Aug;11(4):525-32. doi: 10.1188/07.CJON.525-532. PMID: 17723965
Appendiceal mucoceles and pseudomyxoma peritonei.
Landen S, Bertrand C, Maddern GJ, Herman D, Pourbaix A, de Neve A, Schmitz A
Surg Gynecol Obstet 1992 Nov;175(5):401-4. PMID: 1440166
Tumors of the appendix.
Schmutzer KJ, Bayar M, Zaki AE, Regan JF, Poletti JB
Dis Colon Rectum 1975 May-Jun;18(4):324-31. doi: 10.1007/BF02587395. PMID: 1126268

Recent systematic reviews

Ectopic insulinoma: a systematic review.
Guerrero-Pérez F, Vilarrasa N, Huánuco LV, Busquets J, Secanella L, Vercher-Conejero JL, Vidal N, Näf Cortés S, Villabona C
Rev Endocr Metab Disord 2023 Dec;24(6):1135-1146. Epub 2023 Jul 12 doi: 10.1007/s11154-023-09824-2. PMID: 37434098
Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358

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