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Appendix Tubulovillous Adenoma

MedGen UID:
353393
•Concept ID:
C1706836
•
Neoplastic Process

Definition

An adenoma arising from the appendix. It is characterized by the presence of tubular and villous epithelial structures and it is associated with dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix Tubulovillous Adenoma

Recent clinical studies

Etiology

The role of advanced endoscopy in appendiceal polyp management and outcomes.
Justiniano CF, Ozgur I, Liska D, Valente MA, Steele SR, Gorgun E
Surg Endosc 2024 Apr;38(4):2267-2272. Epub 2024 Mar 4 doi: 10.1007/s00464-024-10726-w. PMID: 38438673Free PMC Article
Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.
Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563
Molecular profiling of appendiceal serrated lesions, polyps and mucinous neoplasms: a single-centre experience.
Munari G, Businello G, Mattiolo P, Pennelli G, Sbaraglia M, Borga C, Pucciarelli S, Spolverato G, Mescoli C, Galuppini F, Sommariva A, Bellan E, Lonardi S, Loupakis F, Luchini C, Dei Tos AP, Fassan M
J Cancer Res Clin Oncol 2021 Jul;147(7):1897-1904. Epub 2021 Mar 12 doi: 10.1007/s00432-021-03589-4. PMID: 33712927Free PMC Article
Underwater EMR of adenomas of the appendiceal orifice (with video).
Binmoeller KF, Hamerski CM, Shah JN, Bhat YM, Kane SD
Gastrointest Endosc 2016 Mar;83(3):638-42. Epub 2015 Sep 14 doi: 10.1016/j.gie.2015.08.079. PMID: 26375437
Tubulovillous adenoma of the appendix: a case report and review of the literature.
Bodin R, Peycru T, Schwartz A, Jarry J, Pommier N, Durand-Dastes F
Gastroenterol Clin Biol 2010 Nov;34(11):633-5. Epub 2010 Aug 23 doi: 10.1016/j.gcb.2010.07.006. PMID: 20739133

Diagnosis

Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.
Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563
Appendiceal cancer leading to intussusception detected incidentally during follow-up for Peutz-Jeghers syndrome.
Kurihara K, Suganuma T
Clin J Gastroenterol 2020 Dec;13(6):1136-1143. Epub 2020 Oct 9 doi: 10.1007/s12328-020-01200-w. PMID: 33034013Free PMC Article
Achieving a complete colonic evaluation in patients with incomplete colonoscopy is worth the effort.
Ridolfi TJ, Valente MA, Church JM
Dis Colon Rectum 2014 Mar;57(3):383-7. doi: 10.1097/DCR.0000000000000072. PMID: 24509464
Appendiceal intussusception induced by tubulovillous adenoma with carcinoma in situ: report of a case.
Ohno M, Nakamura T, Hori H, Tabuchi Y, Kuroda Y
Surg Today 2000;30(5):441-4. doi: 10.1007/s005950050620. PMID: 10819482
Intussusception of the appendix. A report of four cases and review of the literature.
Jevon GP, Daya D, Qizilbash AH
Arch Pathol Lab Med 1992 Sep;116(9):960-4. PMID: 1524463

Therapy

Underwater polypectomy at the appendiceal orifice in a patient on anticoagulation.
Yépez Carpio AF, Zambrano Rosero CN, Cedeño Muñoz RE
Rev Esp Enferm Dig 2024 Jun;116(6):332-333. doi: 10.17235/reed.2023.9842/2023. PMID: 37771309
Outcome of laparoscopic colectomy for polyps not suitable for endoscopic resection.
Pokala N, Delaney CP, Kiran RP, Brady K, Senagore AJ
Surg Endosc 2007 Mar;21(3):400-3. Epub 2006 Dec 16 doi: 10.1007/s00464-006-9069-8. PMID: 17180271

Prognosis

Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.
Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563
Molecular profiling of appendiceal serrated lesions, polyps and mucinous neoplasms: a single-centre experience.
Munari G, Businello G, Mattiolo P, Pennelli G, Sbaraglia M, Borga C, Pucciarelli S, Spolverato G, Mescoli C, Galuppini F, Sommariva A, Bellan E, Lonardi S, Loupakis F, Luchini C, Dei Tos AP, Fassan M
J Cancer Res Clin Oncol 2021 Jul;147(7):1897-1904. Epub 2021 Mar 12 doi: 10.1007/s00432-021-03589-4. PMID: 33712927Free PMC Article
Appendiceal cancer leading to intussusception detected incidentally during follow-up for Peutz-Jeghers syndrome.
Kurihara K, Suganuma T
Clin J Gastroenterol 2020 Dec;13(6):1136-1143. Epub 2020 Oct 9 doi: 10.1007/s12328-020-01200-w. PMID: 33034013Free PMC Article
Tubulovillous adenoma of the appendix: a case report and review of the literature.
Bodin R, Peycru T, Schwartz A, Jarry J, Pommier N, Durand-Dastes F
Gastroenterol Clin Biol 2010 Nov;34(11):633-5. Epub 2010 Aug 23 doi: 10.1016/j.gcb.2010.07.006. PMID: 20739133
Appendiceal intussusception induced by tubulovillous adenoma with carcinoma in situ: report of a case.
Ohno M, Nakamura T, Hori H, Tabuchi Y, Kuroda Y
Surg Today 2000;30(5):441-4. doi: 10.1007/s005950050620. PMID: 10819482

Clinical prediction guides

The role of advanced endoscopy in appendiceal polyp management and outcomes.
Justiniano CF, Ozgur I, Liska D, Valente MA, Steele SR, Gorgun E
Surg Endosc 2024 Apr;38(4):2267-2272. Epub 2024 Mar 4 doi: 10.1007/s00464-024-10726-w. PMID: 38438673Free PMC Article
Appendiceal cancer leading to intussusception detected incidentally during follow-up for Peutz-Jeghers syndrome.
Kurihara K, Suganuma T
Clin J Gastroenterol 2020 Dec;13(6):1136-1143. Epub 2020 Oct 9 doi: 10.1007/s12328-020-01200-w. PMID: 33034013Free PMC Article
Underwater EMR of adenomas of the appendiceal orifice (with video).
Binmoeller KF, Hamerski CM, Shah JN, Bhat YM, Kane SD
Gastrointest Endosc 2016 Mar;83(3):638-42. Epub 2015 Sep 14 doi: 10.1016/j.gie.2015.08.079. PMID: 26375437

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