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Cervical Invasive Stratified Mucinous Adenocarcinoma

MedGen UID:
1793111
•Concept ID:
C5556670
•
Neoplastic Process
Synonyms: Cervical Invasive Stratified Mucinous Carcinoma; Invasive Stratified Mucinous Adenocarcinoma; Invasive Stratified Mucinous Carcinoma

Definition

A rare, distinct form of invasive cervical mucinous adenocarcinoma associated with human papillomavirus infection. It is characterized by the presence of strati?ed, immature epithelial cells containing varying quantities of intracytoplasmic mucin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Invasive Stratified Mucinous Adenocarcinoma

Professional guidelines

PubMed

International Endocervical Adenocarcinoma Criteria and Classification (IECC): correlation with adverse clinicopathological features and patient outcome.
Hodgson A, Olkhov-Mitsel E, Howitt BE, Nucci MR, Parra-Herran C
J Clin Pathol 2019 May;72(5):347-353. Epub 2019 Jan 24 doi: 10.1136/jclinpath-2018-205632. PMID: 30679193
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Recent clinical studies

Etiology

Cervical Adenosquamous Carcinoma: Detailed Analysis of Morphology, Immunohistochemical Profile, and Outcome in 59 Cases.
Stolnicu S, Hoang L, Zhou Q, Iasonos A, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Oliva E, Park KJ, Soslow RA
Int J Gynecol Pathol 2023 May 1;42(3):259-269. Epub 2022 Aug 31 doi: 10.1097/PGP.0000000000000921. PMID: 36044310Free PMC Article
Membranous and nuclear staining of CLDN18 in HPV-independent and HPV-associated endocervical adenocarcinomas.
Du X, Hu Y, Ji X, Sui L, Zheng Q, Song K, Lv T, Chen Y, Zhao H, Dai S, Zhao P, Yao Q
Cancer Med 2023 Jan;12(2):1441-1450. Epub 2022 Jul 21 doi: 10.1002/cam4.5029. PMID: 35861118Free PMC Article
Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.
Lin T, Wang W, Xu L, He Y
Arch Gynecol Obstet 2022 Nov;306(5):1703-1709. Epub 2022 Apr 8 doi: 10.1007/s00404-022-06544-x. PMID: 35394200
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Diagnosis

Cervical Adenosquamous Carcinoma: Detailed Analysis of Morphology, Immunohistochemical Profile, and Outcome in 59 Cases.
Stolnicu S, Hoang L, Zhou Q, Iasonos A, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Oliva E, Park KJ, Soslow RA
Int J Gynecol Pathol 2023 May 1;42(3):259-269. Epub 2022 Aug 31 doi: 10.1097/PGP.0000000000000921. PMID: 36044310Free PMC Article
Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.
Lin T, Wang W, Xu L, He Y
Arch Gynecol Obstet 2022 Nov;306(5):1703-1709. Epub 2022 Apr 8 doi: 10.1007/s00404-022-06544-x. PMID: 35394200
Invasive Stratified Mucin-producing Carcinoma (ISMC) of the Cervix: A Study on Morphologic Diversity.
Stolnicu S, Segura S, Parra-Herran C, Horn LC, Hoang L, Terinte C, Pesci A, Aviel-Ronen S, Kyokawa T, Alvarado-Cabrero I, Oliva E, Soslow RA, Park KJ
Am J Surg Pathol 2020 Jul;44(7):873-880. doi: 10.1097/PAS.0000000000001480. PMID: 32235154Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Therapy

Pathologic response rate after concomitant neo-adjuvant radiotherapy and chemotherapy for adenocarcinoma of the uterine cervix: a retrospective multicentric study.
Poujade O, Morice P, Rouzier R, Madelenat P, Lecuru F, Muray JM, Mathevet P, Alran S, Salmon RJ, Reyal F
Int J Gynecol Cancer 2010 Jul;20(5):815-20. doi: 10.1111/IGC.0b013e3181df7406. PMID: 20606528

Prognosis

Membranous and nuclear staining of CLDN18 in HPV-independent and HPV-associated endocervical adenocarcinomas.
Du X, Hu Y, Ji X, Sui L, Zheng Q, Song K, Lv T, Chen Y, Zhao H, Dai S, Zhao P, Yao Q
Cancer Med 2023 Jan;12(2):1441-1450. Epub 2022 Jul 21 doi: 10.1002/cam4.5029. PMID: 35861118Free PMC Article
Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.
Lin T, Wang W, Xu L, He Y
Arch Gynecol Obstet 2022 Nov;306(5):1703-1709. Epub 2022 Apr 8 doi: 10.1007/s00404-022-06544-x. PMID: 35394200
Invasive Stratified Mucinous Carcinoma (iSMC) of the Cervix Often Presents With High-risk Features That Are Determinants of Poor Outcome: An International Multicenter Study.
Stolnicu S, Boros M, Segura S, Horn LC, Parra-Herran C, Oliva E, Abu-Rustum N, Soslow RA, Park KJ
Am J Surg Pathol 2020 Oct;44(10):1374-1380. doi: 10.1097/PAS.0000000000001485. PMID: 32271191Free PMC Article
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Clinical prediction guides

Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.
Lin T, Wang W, Xu L, He Y
Arch Gynecol Obstet 2022 Nov;306(5):1703-1709. Epub 2022 Apr 8 doi: 10.1007/s00404-022-06544-x. PMID: 35394200
Tumor budding is an adverse prognostic marker in intestinal-type sinonasal adenocarcinoma and seems to be unrelated to epithelial-mesenchymal transition.
Maffeis V, Cappellesso R, Galuppini F, Guzzardo V, Zanon A, Cazzador D, Emanuelli E, Ventura L, Martini A, Fassina A
Virchows Arch 2020 Aug;477(2):241-248. Epub 2020 Jan 24 doi: 10.1007/s00428-020-02748-1. PMID: 31980958
Diagnostic Algorithmic Proposal Based on Comprehensive Immunohistochemical Evaluation of 297 Invasive Endocervical Adenocarcinomas.
Stolnicu S, Barsan I, Hoang L, Patel P, Chiriboga L, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Aug;42(8):989-1000. doi: 10.1097/PAS.0000000000001090. PMID: 29851704Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Stratified mucin-producing intraepithelial lesion with invasive carcinoma: 12 cases with immunohistochemical and ultrastructural findings.
Onishi J, Sato Y, Sawaguchi A, Yamashita A, Maekawa K, Sameshima H, Asada Y
Hum Pathol 2016 Sep;55:174-81. Epub 2016 May 27 doi: 10.1016/j.humpath.2016.05.007. PMID: 27237368

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