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Cervical mucinous adenocarcinoma, minimal deviation variant

MedGen UID:
273125
•Concept ID:
C1516423
•
Neoplastic Process
Synonyms: Cervical Adenoma Malignum; cervical adenoma malignum; Cervical Mucinous Adenocarcinoma, Gastric Type; Cervical Mucinous Adenocarcinoma, Minimal Deviation Type; cervical mucinous adenocarcinoma, minimal deviation type; Cervical Mucinous Adenocarcinoma, Minimal Deviation Variant; cervical mucinous adenocarcinoma, minimal deviation variant; HPV-Independent Cervical Adenocarcinoma, Gastric-Type; Human Papillomavirus-Independent Cervical Adenocarcinoma, Gastric Type; Human Papillomavirus-Independent Cervical Adenocarcinoma, Gastric-Type
 
Monarch Initiative: MONDO:0006140

Definition

Cervical adenocarcinoma characterized by the presence of gastric differentiation. It is not associated with human papillomavirus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical mucinous adenocarcinoma, minimal deviation variant

Professional guidelines

PubMed

Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis.
Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781

Recent clinical studies

Etiology

Gastric-type mucinous carcinoma of the cervix and its precursors - historical overview.
Mikami Y
Histopathology 2020 Jan;76(1):102-111. doi: 10.1111/his.13993. PMID: 31846534
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
A Detailed Immunohistochemical Analysis of a Large Series of Cervical and Vaginal Gastric-type Adenocarcinomas.
Carleton C, Hoang L, Sah S, Kiyokawa T, Karamurzin YS, Talia KL, Park KJ, McCluggage WG
Am J Surg Pathol 2016 May;40(5):636-44. doi: 10.1097/PAS.0000000000000578. PMID: 26685087Free PMC Article
Cytologic features of gastric-type adenocarcinoma of the uterine cervix.
Kawakami F, Mikami Y, Sudo T, Fujiwara K, Hirose T, Itoh T
Diagn Cytopathol 2015 Oct;43(10):791-6. Epub 2015 Jul 14 doi: 10.1002/dc.23304. PMID: 26173165
Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix.
Kojima A, Mikami Y, Sudo T, Yamaguchi S, Kusanagi Y, Ito M, Nishimura R
Am J Surg Pathol 2007 May;31(5):664-72. doi: 10.1097/01.pas.0000213434.91868.b0. PMID: 17460448

Diagnosis

The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
A Detailed Immunohistochemical Analysis of a Large Series of Cervical and Vaginal Gastric-type Adenocarcinomas.
Carleton C, Hoang L, Sah S, Kiyokawa T, Karamurzin YS, Talia KL, Park KJ, McCluggage WG
Am J Surg Pathol 2016 May;40(5):636-44. doi: 10.1097/PAS.0000000000000578. PMID: 26685087Free PMC Article
Cytologic features of gastric-type adenocarcinoma of the uterine cervix.
Kawakami F, Mikami Y, Sudo T, Fujiwara K, Hirose T, Itoh T
Diagn Cytopathol 2015 Oct;43(10):791-6. Epub 2015 Jul 14 doi: 10.1002/dc.23304. PMID: 26173165
Pseudoneoplastic glandular lesions of the uterine cervix: a selective review.
Nucci MR
Int J Gynecol Pathol 2014 Jul;33(4):330-8. doi: 10.1097/PGP.0000000000000139. PMID: 24901392
Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis.
Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781

Prognosis

The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
A Detailed Immunohistochemical Analysis of a Large Series of Cervical and Vaginal Gastric-type Adenocarcinomas.
Carleton C, Hoang L, Sah S, Kiyokawa T, Karamurzin YS, Talia KL, Park KJ, McCluggage WG
Am J Surg Pathol 2016 May;40(5):636-44. doi: 10.1097/PAS.0000000000000578. PMID: 26685087Free PMC Article
Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis.
Karamurzin YS, Kiyokawa T, Parkash V, Jotwani AR, Patel P, Pike MC, Soslow RA, Park KJ
Am J Surg Pathol 2015 Nov;39(11):1449-57. doi: 10.1097/PAS.0000000000000532. PMID: 26457350Free PMC Article
A panel of 3 markers including p16, ProExC, or HPV ISH is optimal for distinguishing between primary endometrial and endocervical adenocarcinomas.
Kong CS, Beck AH, Longacre TA
Am J Surg Pathol 2010 Jul;34(7):915-26. doi: 10.1097/PAS.0b013e3181e3291e. PMID: 20534993Free PMC Article
Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix.
Kojima A, Mikami Y, Sudo T, Yamaguchi S, Kusanagi Y, Ito M, Nishimura R
Am J Surg Pathol 2007 May;31(5):664-72. doi: 10.1097/01.pas.0000213434.91868.b0. PMID: 17460448

Clinical prediction guides

A Detailed Immunohistochemical Analysis of a Large Series of Cervical and Vaginal Gastric-type Adenocarcinomas.
Carleton C, Hoang L, Sah S, Kiyokawa T, Karamurzin YS, Talia KL, Park KJ, McCluggage WG
Am J Surg Pathol 2016 May;40(5):636-44. doi: 10.1097/PAS.0000000000000578. PMID: 26685087Free PMC Article
Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis.
Karamurzin YS, Kiyokawa T, Parkash V, Jotwani AR, Patel P, Pike MC, Soslow RA, Park KJ
Am J Surg Pathol 2015 Nov;39(11):1449-57. doi: 10.1097/PAS.0000000000000532. PMID: 26457350Free PMC Article
Cytologic features of gastric-type adenocarcinoma of the uterine cervix.
Kawakami F, Mikami Y, Sudo T, Fujiwara K, Hirose T, Itoh T
Diagn Cytopathol 2015 Oct;43(10):791-6. Epub 2015 Jul 14 doi: 10.1002/dc.23304. PMID: 26173165
Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix.
Kojima A, Mikami Y, Sudo T, Yamaguchi S, Kusanagi Y, Ito M, Nishimura R
Am J Surg Pathol 2007 May;31(5):664-72. doi: 10.1097/01.pas.0000213434.91868.b0. PMID: 17460448
CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma.
McCluggage WG, Oliva E, Herrington CS, McBride H, Young RH
Histopathology 2003 Aug;43(2):144-50. doi: 10.1046/j.1365-2559.2003.01684.x. PMID: 12877729

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