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Abnormal granulocyte count

MedGen UID:
1704843
•Concept ID:
C5139264
•
Finding
HPO: HP:0032309

Definition

Any deviation from the normal cell count per volume of granulocytes in the blood circulation. [from HPO]

Professional guidelines

PubMed

Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte-Macrophage Colony-Stimulating Factor: A Systematic Review.
Lally J, Malik S, Whiskey E, Taylor DM, Gaughran FP, Krivoy A, Flanagan RJ, Mijovic A, MacCabe JH
J Clin Psychopharmacol 2017 Aug;37(4):441-446. doi: 10.1097/JCP.0000000000000715. PMID: 28437295
Autoimmune Neutropenia Updates: Etiology, Pathology, and Treatment.
Afzal W, Owlia MB, Hasni S, Newman KA
South Med J 2017 Apr;110(4):300-307. doi: 10.14423/SMJ.0000000000000637. PMID: 28376530
Evaluation and management of patients with isolated neutropenia.
Newburger PE, Dale DC
Semin Hematol 2013 Jul;50(3):198-206. doi: 10.1053/j.seminhematol.2013.06.010. PMID: 23953336Free PMC Article

Recent clinical studies

Etiology

Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.
de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506Free PMC Article
When non-Whiteness becomes a condition.
Merz LE, Achebe M
Blood 2021 Jan 7;137(1):13-15. doi: 10.1182/blood.2020008600. PMID: 33181819
Severe congenital neutropenias.
Skokowa J, Dale DC, Touw IP, Zeidler C, Welte K
Nat Rev Dis Primers 2017 Jun 8;3:17032. doi: 10.1038/nrdp.2017.32. PMID: 28593997Free PMC Article
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article
The consequences of not having eosinophils.
Gleich GJ, Klion AD, Lee JJ, Weller PF
Allergy 2013 Jul;68(7):829-35. Epub 2013 Jun 6 doi: 10.1111/all.12169. PMID: 23742015Free PMC Article

Diagnosis

Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma.
Tang M, Charbit AR, Johansson MW, Jarjour NN, Denlinger LC, Raymond WW, Peters MC, Dunican EM, Castro M, Sumino K, Erzurum SC, Comhair SA, Moore WC, Levy BD, Israel E, Phipatanakul W, Phillips BR, Mauger DT, Bleecker ER, Wenzel SE, Fajt ML, Woodruff PG, Hastie AT, Fahy JV; National Heart Lung and Blood Institute Severe Asthma Research Program
J Allergy Clin Immunol 2024 Sep;154(3):580-591.e6. Epub 2024 Apr 23 doi: 10.1016/j.jaci.2024.03.023. PMID: 38663815
Histopathology of Eosinophilic Esophagitis.
Collins MH, Arva NC, Bernieh A, Lopez-Nunez O, Pletneva M, Yang GY
Immunol Allergy Clin North Am 2024 May;44(2):205-221. Epub 2024 Jan 16 doi: 10.1016/j.iac.2023.12.008. PMID: 38575219
Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.
de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506Free PMC Article
Severe congenital neutropenias.
Skokowa J, Dale DC, Touw IP, Zeidler C, Welte K
Nat Rev Dis Primers 2017 Jun 8;3:17032. doi: 10.1038/nrdp.2017.32. PMID: 28593997Free PMC Article
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article

Therapy

Eosinophil Depletion with Benralizumab for Eosinophilic Esophagitis.
Rothenberg ME, Dellon ES, Collins MH, Bredenoord AJ, Hirano I, Peterson KA, Brooks L, Caldwell JM, Fjällbrant H, Grindebacke H, Ho CN, Keith M, McCrae C, Sinibaldi D, White WI, Datto CJ; MESSINA Trial Investigators
N Engl J Med 2024 Jun 27;390(24):2252-2263. doi: 10.1056/NEJMoa2313318. PMID: 38924732
Interactions of HIV and Antiretroviral Therapy With Neutrophils and Platelets.
Madzime M, Rossouw TM, Theron AJ, Anderson R, Steel HC
Front Immunol 2021;12:634386. Epub 2021 Mar 12 doi: 10.3389/fimmu.2021.634386. PMID: 33777022Free PMC Article
Severe congenital neutropenias.
Skokowa J, Dale DC, Touw IP, Zeidler C, Welte K
Nat Rev Dis Primers 2017 Jun 8;3:17032. doi: 10.1038/nrdp.2017.32. PMID: 28593997Free PMC Article
The consequences of not having eosinophils.
Gleich GJ, Klion AD, Lee JJ, Weller PF
Allergy 2013 Jul;68(7):829-35. Epub 2013 Jun 6 doi: 10.1111/all.12169. PMID: 23742015Free PMC Article
Dyskeratosis congenita.
Gupta V, Kumar A
Adv Exp Med Biol 2010;685:215-9. doi: 10.1007/978-1-4419-6448-9_20. PMID: 20687509

Prognosis

Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.
de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506Free PMC Article
The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
Myeloproliferative neoplasms: Diagnostic workup of the cythemic patient.
Wong WJ, Pozdnyakova O
Int J Lab Hematol 2019 May;41 Suppl 1:142-150. doi: 10.1111/ijlh.13005. PMID: 31069979
Severe congenital neutropenias.
Skokowa J, Dale DC, Touw IP, Zeidler C, Welte K
Nat Rev Dis Primers 2017 Jun 8;3:17032. doi: 10.1038/nrdp.2017.32. PMID: 28593997Free PMC Article
The consequences of not having eosinophils.
Gleich GJ, Klion AD, Lee JJ, Weller PF
Allergy 2013 Jul;68(7):829-35. Epub 2013 Jun 6 doi: 10.1111/all.12169. PMID: 23742015Free PMC Article

Clinical prediction guides

Eosinophil Depletion with Benralizumab for Eosinophilic Esophagitis.
Rothenberg ME, Dellon ES, Collins MH, Bredenoord AJ, Hirano I, Peterson KA, Brooks L, Caldwell JM, Fjällbrant H, Grindebacke H, Ho CN, Keith M, McCrae C, Sinibaldi D, White WI, Datto CJ; MESSINA Trial Investigators
N Engl J Med 2024 Jun 27;390(24):2252-2263. doi: 10.1056/NEJMoa2313318. PMID: 38924732
Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma.
Tang M, Charbit AR, Johansson MW, Jarjour NN, Denlinger LC, Raymond WW, Peters MC, Dunican EM, Castro M, Sumino K, Erzurum SC, Comhair SA, Moore WC, Levy BD, Israel E, Phipatanakul W, Phillips BR, Mauger DT, Bleecker ER, Wenzel SE, Fajt ML, Woodruff PG, Hastie AT, Fahy JV; National Heart Lung and Blood Institute Severe Asthma Research Program
J Allergy Clin Immunol 2024 Sep;154(3):580-591.e6. Epub 2024 Apr 23 doi: 10.1016/j.jaci.2024.03.023. PMID: 38663815
Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.
de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506Free PMC Article
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article
The consequences of not having eosinophils.
Gleich GJ, Klion AD, Lee JJ, Weller PF
Allergy 2013 Jul;68(7):829-35. Epub 2013 Jun 6 doi: 10.1111/all.12169. PMID: 23742015Free PMC Article

Recent systematic reviews

Immune System Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.
Hall MW, Carcillo JA, Cornell T; Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative
Pediatrics 2022 Jan 1;149(1 Suppl 1):S91-S98. doi: 10.1542/peds.2021-052888N. PMID: 34970674Free PMC Article
Neutropenia in patients with hyperthyroidism: Systematic review and meta-analysis.
Scappaticcio L, Maiorino MI, Maio A, Esposito K, Bellastella G
Clin Endocrinol (Oxf) 2021 Mar;94(3):473-483. Epub 2020 Sep 1 doi: 10.1111/cen.14313. PMID: 32799342
Cobalamin deficiency presenting with thrombotic microangiopathy (TMA) features: A systematic review.
Tran PN, Tran MH
Transfus Apher Sci 2018 Feb;57(1):102-106. Epub 2018 Jan 11 doi: 10.1016/j.transci.2018.01.003. PMID: 29454538
The Use of Granulocyte Colony-Stimulating Factor in Clozapine Rechallenge: A Systematic Review.
Lally J, Malik S, Krivoy A, Whiskey E, Taylor DM, Gaughran FP, Flanagan RJ, Mijovic A, MacCabe JH
J Clin Psychopharmacol 2017 Oct;37(5):600-604. doi: 10.1097/JCP.0000000000000767. PMID: 28817489
Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte-Macrophage Colony-Stimulating Factor: A Systematic Review.
Lally J, Malik S, Whiskey E, Taylor DM, Gaughran FP, Krivoy A, Flanagan RJ, Mijovic A, MacCabe JH
J Clin Psychopharmacol 2017 Aug;37(4):441-446. doi: 10.1097/JCP.0000000000000715. PMID: 28437295

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