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Increased circulating metamyelocyte count

MedGen UID:
1694856
•Concept ID:
C5139217
•
Finding
HPO: HP:0032238

Definition

The number of metamyelocytes in the peripheral blood circulation is above the upper limit of normal. Metamyelocytes are immature neutrophils with a size of 10-18 micrometers, an indented or kidney-shaped nucleus, pinkish-blue staining cytoplasm with secondary granules, and a nucleus:cytoplasm ratio of 1.5:1. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating metamyelocyte count

Recent clinical studies

Etiology

GLP-1RA therapy increases circulating vascular regenerative cell content in people living with type 2 diabetes.
Park B, Krishnaraj A, Teoh H, Bakbak E, Dennis F, Quan A, Hess DA, Verma S
Am J Physiol Heart Circ Physiol 2024 Aug 1;327(2):H370-H376. Epub 2024 Jun 14 doi: 10.1152/ajpheart.00257.2024. PMID: 38874618
A secondary CD34+ acute lymphoblastic leukemia unmasked and mobilized by G-CSF in an autologous stem cell donor with testicular cancer.
Cooling L, Kelley J, Sexton E, Anand S, Hoffmann S
Transfusion 2023 Apr;63(4):684-689. Epub 2023 Feb 10 doi: 10.1111/trf.17269. PMID: 36762622
Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma.
Sehmi R, Smith SG, Kjarsgaard M, Radford K, Boulet LP, Lemiere C, Prazma CM, Ortega H, Martin JG, Nair P
Clin Exp Allergy 2016 Jun;46(6):793-802. doi: 10.1111/cea.12695. PMID: 26685004
Increased promyelocytic-derived microparticles: a novel potential factor for coagulopathy in acute promyelocytic leukemia.
Ma G, Liu F, Lv L, Gao Y, Su Y
Ann Hematol 2013 May;92(5):645-52. Epub 2013 Jan 24 doi: 10.1007/s00277-013-1676-6. PMID: 23344645
Comparative study of peripheral blood progenitor cell collection in patients with multiple myeloma after single-dose cyclophosphamide combined with rhGM-CSF or rhG-CSF.
Demuynck H, Delforge M, Verhoef G, Zachée P, Vandenberghe P, Boogaerts M
Br J Haematol 1995 Jun;90(2):384-92. doi: 10.1111/j.1365-2141.1995.tb05163.x. PMID: 7540856

Diagnosis

A secondary CD34+ acute lymphoblastic leukemia unmasked and mobilized by G-CSF in an autologous stem cell donor with testicular cancer.
Cooling L, Kelley J, Sexton E, Anand S, Hoffmann S
Transfusion 2023 Apr;63(4):684-689. Epub 2023 Feb 10 doi: 10.1111/trf.17269. PMID: 36762622
Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma.
Sehmi R, Smith SG, Kjarsgaard M, Radford K, Boulet LP, Lemiere C, Prazma CM, Ortega H, Martin JG, Nair P
Clin Exp Allergy 2016 Jun;46(6):793-802. doi: 10.1111/cea.12695. PMID: 26685004
The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation.
Mare TA, Treacher DF, Shankar-Hari M, Beale R, Lewis SM, Chambers DJ, Brown KA
Crit Care 2015 Feb 25;19(1):57. doi: 10.1186/s13054-015-0778-z. PMID: 25887201Free PMC Article
Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells.
Kalinkovich A, Tavor S, Avigdor A, Kahn J, Brill A, Petit I, Goichberg P, Tesio M, Netzer N, Naparstek E, Hardan I, Nagler A, Resnick I, Tsimanis A, Lapidot T
Cancer Res 2006 Nov 15;66(22):11013-20. doi: 10.1158/0008-5472.CAN-06-2006. PMID: 17108140
Mobilization and transplantation of Philadelphia-negative peripheral-blood progenitor cells early in chronic myelogenous leukemia.
Carella AM, Cunningham I, Lerma E, Dejana A, Benvenuto F, Podestà M, Celesti L, Chimirri F, Abote M, Vassallo F, Figari O, Parodi C, Sessarego M, Valbonesi M, Carlier P, Prencipe E, Gatti AM, van den Berg D, Hoffman R, Frassoni F
J Clin Oncol 1997 Apr;15(4):1575-82. doi: 10.1200/JCO.1997.15.4.1575. PMID: 9193355

Therapy

GLP-1RA therapy increases circulating vascular regenerative cell content in people living with type 2 diabetes.
Park B, Krishnaraj A, Teoh H, Bakbak E, Dennis F, Quan A, Hess DA, Verma S
Am J Physiol Heart Circ Physiol 2024 Aug 1;327(2):H370-H376. Epub 2024 Jun 14 doi: 10.1152/ajpheart.00257.2024. PMID: 38874618
Immature cell fractions after cessation of chronic P2Y(12)-inhibition in patients with coronary artery diseases.
Jäger B, Vargas KG, Haller PM, Stojkovic S, Kaufmann CC, Freynhofer M, Quehenberger P, Wagner O, Wojta J, Huber K
Platelets 2021 Aug 18;32(6):815-820. Epub 2020 Aug 7 doi: 10.1080/09537104.2020.1803252. PMID: 32762577
Transgene expression of biological active recombinant human granulocyte-colony stimulating factor (hG-CSF) into mouse urine.
Kim MO, Kim SH, Lee SR, Kim KS, Min KS, Lee HT, Kim SJ, Ryoo ZY
Life Sci 2006 Jan 25;78(9):1003-9. Epub 2005 Sep 15 doi: 10.1016/j.lfs.2005.06.011. PMID: 16168442
Comparative study of peripheral blood progenitor cell collection in patients with multiple myeloma after single-dose cyclophosphamide combined with rhGM-CSF or rhG-CSF.
Demuynck H, Delforge M, Verhoef G, Zachée P, Vandenberghe P, Boogaerts M
Br J Haematol 1995 Jun;90(2):384-92. doi: 10.1111/j.1365-2141.1995.tb05163.x. PMID: 7540856
Splenic irradiation in myelofibrosis: effect on circulating myeloid progenitor cells.
Koeffler HP, Cline MJ, Golde DW
Br J Haematol 1979 Sep;43(1):69-77. doi: 10.1111/j.1365-2141.1979.tb03721.x. PMID: 508623

Prognosis

Immature cell fractions after cessation of chronic P2Y(12)-inhibition in patients with coronary artery diseases.
Jäger B, Vargas KG, Haller PM, Stojkovic S, Kaufmann CC, Freynhofer M, Quehenberger P, Wagner O, Wojta J, Huber K
Platelets 2021 Aug 18;32(6):815-820. Epub 2020 Aug 7 doi: 10.1080/09537104.2020.1803252. PMID: 32762577
The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation.
Mare TA, Treacher DF, Shankar-Hari M, Beale R, Lewis SM, Chambers DJ, Brown KA
Crit Care 2015 Feb 25;19(1):57. doi: 10.1186/s13054-015-0778-z. PMID: 25887201Free PMC Article
Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells.
Kalinkovich A, Tavor S, Avigdor A, Kahn J, Brill A, Petit I, Goichberg P, Tesio M, Netzer N, Naparstek E, Hardan I, Nagler A, Resnick I, Tsimanis A, Lapidot T
Cancer Res 2006 Nov 15;66(22):11013-20. doi: 10.1158/0008-5472.CAN-06-2006. PMID: 17108140
Comparison of in vivo and in vitro effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with acute myeloid leukemia.
Estrov Z, Estey EH, Andreeff M, Talpaz M, Kurzrock R, Reading CL, Deisseroth AB, Gutterman JU
Exp Hematol 1992 Jun;20(5):558-64. PMID: 1587302
Neutrophil marrow profiles in patients with rheumatoid arthritis and neutropenia.
Dancey JT, Brubaker LH
Br J Haematol 1979 Dec;43(4):607-17. doi: 10.1111/j.1365-2141.1979.tb03793.x. PMID: 526442

Clinical prediction guides

Transgene expression of biological active recombinant human granulocyte-colony stimulating factor (hG-CSF) into mouse urine.
Kim MO, Kim SH, Lee SR, Kim KS, Min KS, Lee HT, Kim SJ, Ryoo ZY
Life Sci 2006 Jan 25;78(9):1003-9. Epub 2005 Sep 15 doi: 10.1016/j.lfs.2005.06.011. PMID: 16168442
Comparative study of peripheral blood progenitor cell collection in patients with multiple myeloma after single-dose cyclophosphamide combined with rhGM-CSF or rhG-CSF.
Demuynck H, Delforge M, Verhoef G, Zachée P, Vandenberghe P, Boogaerts M
Br J Haematol 1995 Jun;90(2):384-92. doi: 10.1111/j.1365-2141.1995.tb05163.x. PMID: 7540856
Recombinant granulocyte colony-stimulating factor administration to healthy volunteers: induction of immunophenotypically and functionally altered neutrophils via an effect on myeloid progenitor cells.
Kerst JM, de Haas M, van der Schoot CE, Slaper-Cortenbach IC, Kleijer M, von dem Borne AE, van Oers RH
Blood 1993 Dec 1;82(11):3265-72. PMID: 7694676
Successful autologous transplantation of blood stem cells mobilized with recombinant human granulocyte-macrophage colony-stimulating factor.
Haas R, Ho AD, Bredthauer U, Cayeux S, Egerer G, Knauf W, Hunstein W
Exp Hematol 1990 Feb;18(2):94-8. PMID: 1968009
Splenic irradiation in myelofibrosis: effect on circulating myeloid progenitor cells.
Koeffler HP, Cline MJ, Golde DW
Br J Haematol 1979 Sep;43(1):69-77. doi: 10.1111/j.1365-2141.1979.tb03721.x. PMID: 508623

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