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Neutrophilia in presence of infection

MedGen UID:
1707092
•Concept ID:
C5139433
•
Finding
HPO: HP:0410257

Definition

An increased number of neutrophils circulating in the blood during an infection, such as with a bacteria, virus or fungus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Neutrophilia in presence of infection

Professional guidelines

PubMed

Diagnosis and management of neutrophilic myeloid neoplasms.
Schwede M, Gotlib J, Shomali W
Clin Adv Hematol Oncol 2021 Jul;19(7):450-459. PMID: 34236344

Recent clinical studies

Etiology

Evaluation of the Levels of Blood Cells, Vitamin D, and Inflammatory Factors in Children with PFAPA Syndrome.
Abbasi E, Mamizadeh N, Seidkhani H, Khoshnood S, Mohamadi J
Clin Lab 2023 Nov 1;69(11) doi: 10.7754/Clin.Lab.2023.230518. PMID: 37948479
Haematological changes in sailors who had COVID-19.
Ignatyev O, Panyita O, Prutiian T, Kostromin P
Int Marit Health 2022;73(4):178-180. doi: 10.5603/IMH.2022.0031. PMID: 36583404
Outcomes and Prognostic Factors in a Large Cohort of Hospitalized Cancer Patients With COVID-19.
Nader Marta G, Colombo Bonadio R, Nicole Encinas Sejas O, Watarai G, Mathias Machado MC, Teixeira Frasson L, Motta Venchiarutti Moniz C, de Luca Ito RK, Peixoto D, Oliveira Hoff C, Menegatti Anastacio V, Ribeiro U Jr, Pereira J, Rocha V, Abdala E, Del Pilar Estevez-Diz M, Hoff PM
JCO Glob Oncol 2021 Jun;7:1084-1092. doi: 10.1200/GO.21.00087. PMID: 34228508Free PMC Article
Use of C-reactive protein concentration in evaluation of diskospondylitis in dogs.
Trub SA, Bush WW, Paek M, Cuff DE
J Vet Intern Med 2021 Jan;35(1):209-216. Epub 2020 Dec 14 doi: 10.1111/jvim.15981. PMID: 33319417Free PMC Article
Creation and assessment of a clinical predictive model for candidaemia in patients with candiduria.
Wang K, Hsueh K, Kronen R, Lin C, Salazar AS, Powderly WG, Spec A
Mycoses 2019 Jul;62(7):554-561. Epub 2019 May 22 doi: 10.1111/myc.12917. PMID: 31025417Free PMC Article

Diagnosis

A Review of Morphologic Findings in Peripheral Blood Smears of COVID-19 Patients.
Jain PV, Grover A, Nomani L
WMJ 2023 Dec;122(5):357-363. PMID: 38180924
Evaluation of the Levels of Blood Cells, Vitamin D, and Inflammatory Factors in Children with PFAPA Syndrome.
Abbasi E, Mamizadeh N, Seidkhani H, Khoshnood S, Mohamadi J
Clin Lab 2023 Nov 1;69(11) doi: 10.7754/Clin.Lab.2023.230518. PMID: 37948479
Diagnosis and management of neutrophilic myeloid neoplasms.
Schwede M, Gotlib J, Shomali W
Clin Adv Hematol Oncol 2021 Jul;19(7):450-459. PMID: 34236344
Use of C-reactive protein concentration in evaluation of diskospondylitis in dogs.
Trub SA, Bush WW, Paek M, Cuff DE
J Vet Intern Med 2021 Jan;35(1):209-216. Epub 2020 Dec 14 doi: 10.1111/jvim.15981. PMID: 33319417Free PMC Article
The role of neutrophils in immune dysfunction during severe inflammation.
Leliefeld PH, Wessels CM, Leenen LP, Koenderman L, Pillay J
Crit Care 2016 Mar 23;20:73. doi: 10.1186/s13054-016-1250-4. PMID: 27005275Free PMC Article

Therapy

Diagnosis and management of neutrophilic myeloid neoplasms.
Schwede M, Gotlib J, Shomali W
Clin Adv Hematol Oncol 2021 Jul;19(7):450-459. PMID: 34236344
Overexpression of hypoxia-inducible factor 1α is associated with neutrophilic inflammation in chronic rhinosinusitis with nasal polyps.
Yu Z, Wang Y, Hu X, Xu H, Han M, Zhang J, Wen W, Shu H, Li H
Auris Nasus Larynx 2020 Jun;47(3):401-409. Epub 2019 Oct 19 doi: 10.1016/j.anl.2019.09.011. PMID: 31635898
The role of neutrophils in immune dysfunction during severe inflammation.
Leliefeld PH, Wessels CM, Leenen LP, Koenderman L, Pillay J
Crit Care 2016 Mar 23;20:73. doi: 10.1186/s13054-016-1250-4. PMID: 27005275Free PMC Article
Methotrexate-induced pneumonitis: heterogeneity of bronchoalveolar lavage and differences between cancer and rheumatoid arthritis.
D'Elia T
Inflamm Allergy Drug Targets 2014 Feb;13(1):25-33. doi: 10.2174/1871528112666131230013059. PMID: 24372368
Late adult respiratory distress syndrome.
Meduri GU
New Horiz 1993 Nov;1(4):563-77. PMID: 8087576

Prognosis

Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19.
Dwivedi A, Ui Mhaonaigh A, Carroll M, Khosravi B, Batten I, Ballantine RS, Hendricken Phelan S, O'Doherty L, George AM, Sui J, Hawerkamp HC, Fallon PG, Noppe E, Mason S, Conlon N, Ni Cheallaigh C, Finlay CM, Little MA, Bioresource OBOTSJATTARS
JCI Insight 2024 Sep 10;9(17) doi: 10.1172/jci.insight.171659. PMID: 39253969Free PMC Article
A Review of Morphologic Findings in Peripheral Blood Smears of COVID-19 Patients.
Jain PV, Grover A, Nomani L
WMJ 2023 Dec;122(5):357-363. PMID: 38180924
Diagnosis and management of neutrophilic myeloid neoplasms.
Schwede M, Gotlib J, Shomali W
Clin Adv Hematol Oncol 2021 Jul;19(7):450-459. PMID: 34236344
Outcomes and Prognostic Factors in a Large Cohort of Hospitalized Cancer Patients With COVID-19.
Nader Marta G, Colombo Bonadio R, Nicole Encinas Sejas O, Watarai G, Mathias Machado MC, Teixeira Frasson L, Motta Venchiarutti Moniz C, de Luca Ito RK, Peixoto D, Oliveira Hoff C, Menegatti Anastacio V, Ribeiro U Jr, Pereira J, Rocha V, Abdala E, Del Pilar Estevez-Diz M, Hoff PM
JCO Glob Oncol 2021 Jun;7:1084-1092. doi: 10.1200/GO.21.00087. PMID: 34228508Free PMC Article
Use of C-reactive protein concentration in evaluation of diskospondylitis in dogs.
Trub SA, Bush WW, Paek M, Cuff DE
J Vet Intern Med 2021 Jan;35(1):209-216. Epub 2020 Dec 14 doi: 10.1111/jvim.15981. PMID: 33319417Free PMC Article

Clinical prediction guides

A Review of Morphologic Findings in Peripheral Blood Smears of COVID-19 Patients.
Jain PV, Grover A, Nomani L
WMJ 2023 Dec;122(5):357-363. PMID: 38180924
An Overview on the Epidemiology and Immunology of COVID-19.
Meskini M, Rezghi Rami M, Maroofi P, Ghosh S, Siadat SD, Sheikhpour M
J Infect Public Health 2021 Oct;14(10):1284-1298. Epub 2021 Aug 4 doi: 10.1016/j.jiph.2021.07.021. PMID: 34420903Free PMC Article
Mucosal Eosinophilia and Neutrophilia Are Not Associated With QOL or Olfactory Function in Chronic Rhinosinusitis.
Farrell NF, Mace JC, Sauer DA, Thomas AJ, Geltzeiler M, Detwiller KY, Smith TL
Am J Rhinol Allergy 2021 Sep;35(5):647-655. Epub 2021 Jan 11 doi: 10.1177/1945892420987439. PMID: 33430615Free PMC Article
Use of C-reactive protein concentration in evaluation of diskospondylitis in dogs.
Trub SA, Bush WW, Paek M, Cuff DE
J Vet Intern Med 2021 Jan;35(1):209-216. Epub 2020 Dec 14 doi: 10.1111/jvim.15981. PMID: 33319417Free PMC Article
Creation and assessment of a clinical predictive model for candidaemia in patients with candiduria.
Wang K, Hsueh K, Kronen R, Lin C, Salazar AS, Powderly WG, Spec A
Mycoses 2019 Jul;62(7):554-561. Epub 2019 May 22 doi: 10.1111/myc.12917. PMID: 31025417Free PMC Article

Recent systematic reviews

A Review of Morphologic Findings in Peripheral Blood Smears of COVID-19 Patients.
Jain PV, Grover A, Nomani L
WMJ 2023 Dec;122(5):357-363. PMID: 38180924
Immunity and inflammatory biomarkers in COVID-19: A systematic review.
Iwamura APD, Tavares da Silva MR, Hümmelgen AL, Soeiro Pereira PV, Falcai A, Grumach AS, Goudouris E, Neto AC, Prando C
Rev Med Virol 2021 Jul;31(4):e2199. Epub 2020 Dec 4 doi: 10.1002/rmv.2199. PMID: 34260778

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    Reviews

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    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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