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Increased circulating IgG subclass

MedGen UID:: 1694486
•Concept ID:: C5139253
•: Finding

HPO:	HP:0032296

Definition

An elevation of circulating IgG level predominantly related to an elevation of one of the four IgG subclasses. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIncreased circulating IgG subclass

Abnormal leukocyte physiology
- Abnormal lymphocyte physiology
  - Abnormality of B cell physiology
    - Abnormal immunoglobulin level
      - Abnormal circulating IgG level
        Increased circulating IgG level
        Increased circulating IgG subclass
        Increased circulating IgG1 level
        Increased circulating IgG2 level
        Increased circulating IgG3 level
        Increased circulating IgG4 level

Professional guidelines

PubMed

Role of ADAMTS13 in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura.

Kremer Hovinga JA, Lämmle B
Hematology Am Soc Hematol Educ Program 2012;2012:610-6. doi: 10.1182/asheducation-2012.1.610. PMID: 23233642

Long-term persistence of anti-factor VIII antibody-secreting cells in hemophilic mice after treatment with human factor VIII.

Hausl C, Maier E, Schwarz HP, Ahmad RU, Turecek PL, Dorner F, Reipert BM
Thromb Haemost 2002 May;87(5):840-5. PMID: 12038787

Serum IgA and IgG subclasses during treatment for acute respiratory exacerbation in cystic fibrosis: analysis of patients colonised with mucoid or non-mucoid strains of pseudomonas aeruginosa.

Hassan J, Feighery C, Bresnihan B, Keogan M, Fitzgerald MX, Whelan A
Immunol Invest 1994 Jan;23(1):1-13. doi: 10.3109/08820139409063428. PMID: 8144195

See all (3)

Recent clinical studies

Etiology

The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis.

Gleeson PJ, Benech N, Chemouny J, Metallinou E, Berthelot L, da Silva J, Bex-Coudrat J, Boedec E, Canesi F, Bounaix C, Morelle W, Moya-Nilges M, Kenny J, O'Mahony L, Saveanu L, Arnulf B, Sannier A, Daugas E, Vrtovsnik F, Lepage P, Sokol H, Monteiro RC
Sci Transl Med 2024 Mar 27;16(740):eadl6149. doi: 10.1126/scitranslmed.adl6149. PMID: 38536935

Containing anti-PLA2R IgG antibody induces podocyte injury in idiopathic membranous nephropathy.

Zhang Y, Chen P, Wang B, Tang X, Wei Y, Cao W, Tang L, Wang Z, Zhao N
Ren Fail 2023;45(2):2271986. Epub 2023 Oct 31 doi: 10.1080/0886022X.2023.2271986. PMID: 37905942 Free PMC Article

Enrichment of serum IgG4 in MuSK myasthenia gravis patients.

Vergoossen DLE, Ruiter AM, Keene KR, Niks EH, Tannemaat MR, Strijbos E, Lipka AF, van der Zijde ECJ, van Tol MJD, Bakker JA, Wevers BA, Westerberg E, Borges LS, Tong OC, Richman DP, Illa I, Punga AR, Evoli A, van der Maarel SM, Verschuuren JJ, Huijbers MG
J Neuroimmunol 2022 Dec 15;373:577978. Epub 2022 Oct 7 doi: 10.1016/j.jneuroim.2022.577978. PMID: 36240543

Mumps-specific IgG, IgG subclasses and neutralization titres to the vaccine and outbreak mumps strains differ in vaccinated healthy controls, breakthrough mumps infection cases and naturally infected individuals.

Foley DJ, Connell AR, Gonzalez G, Connell J, Leahy TR, De Gascun C, Hassan J
J Clin Virol 2022 Dec;157:105296. Epub 2022 Sep 21 doi: 10.1016/j.jcv.2022.105296. PMID: 36209622

Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.

von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAK
Front Immunol 2018;9:3035. Epub 2018 Dec 20 doi: 10.3389/fimmu.2018.03035. PMID: 30619370 Free PMC Article

See all (51)

Diagnosis

ADAMTS-13 conformation influences autoimmune recognition in immune thrombotic thrombocytopenic purpura.

Underwood MI, Thomas MR, Scully MA, Crawley JTB
J Thromb Haemost 2024 Apr;22(4):1069-1079. Epub 2023 Dec 30 doi: 10.1016/j.jtha.2023.12.028. PMID: 38160729

Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease.

Shen CR, Jia XY, Luo W, Olaru F, Cui Z, Zhao MH, Borza DB
J Am Soc Nephrol 2021 Aug;32(8):1887-1897. Epub 2021 Apr 23 doi: 10.1681/ASN.2020101431. PMID: 33893224 Free PMC Article

Alcohol consumption alters anti-Strongyloides stercoralis antibodies production.

De Souza JN, Cruz ADV, Araújo WAC, Sampaio LM, Allegretti SM, Teixeira MCA, Handali S, Galvão-Castro B, Soares NM
Immunobiology 2020 Mar;225(2):151898. Epub 2019 Dec 12 doi: 10.1016/j.imbio.2019.151898. PMID: 31902530

Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.

von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAK
Front Immunol 2018;9:3035. Epub 2018 Dec 20 doi: 10.3389/fimmu.2018.03035. PMID: 30619370 Free PMC Article

Increased sensitivity and high specificity of indirect immunofluorescence in detecting IgG subclasses for diagnosis of bullous pemphigoid.

Jankásková J, Horváth ON, Varga R, Arenberger P, Schmidt E, Ruzicka T, Sárdy M
Clin Exp Dermatol 2018 Apr;43(3):248-253. Epub 2018 Jan 14 doi: 10.1111/ced.13371. PMID: 29333745

See all (25)

Therapy

Safety, tolerability, pharmacokinetics, and pharmacodynamics of HBM9161, a novel FcRn inhibitor, in a phase I study for healthy Chinese volunteers.

Yap DYH, Hai J, Lee PCH, Zhou X, Lee M, Zhang Y, Wang M, Chen X
Clin Transl Sci 2021 Sep;14(5):1769-1779. Epub 2021 Jul 16 doi: 10.1111/cts.13019. PMID: 33742786 Free PMC Article

Update on Transplacental Transfer of IgG Subclasses: Impact of Maternal and Fetal Factors.

Clements T, Rice TF, Vamvakas G, Barnett S, Barnes M, Donaldson B, Jones CE, Kampmann B, Holder B
Front Immunol 2020;11:1920. Epub 2020 Sep 11 doi: 10.3389/fimmu.2020.01920. PMID: 33013843 Free PMC Article

Early-childhood membranous nephropathy due to cationic bovine serum albumin.

Debiec H, Lefeu F, Kemper MJ, Niaudet P, Deschênes G, Remuzzi G, Ulinski T, Ronco P
N Engl J Med 2011 Jun 2;364(22):2101-10. doi: 10.1056/NEJMoa1013792. PMID: 21631322

The relationships among shrimp-specific IgG subclass antibodies and immediate adverse reactions to shrimp challenge.

Morgan JE, Daul CB, Lehrer SB
J Allergy Clin Immunol 1990 Sep;86(3 Pt 1):387-92. doi: 10.1016/s0091-6749(05)80102-2. PMID: 2212410

Diagnosis and immunotherapy of mould allergy. VII. IgG subclass response and relation to the clinical efficacy of immunotherapy with Cladosporium.

Malling HJ, Djurup R
Allergy 1988 Jan;43(1):60-70. doi: 10.1111/j.1398-9995.1988.tb02045.x. PMID: 3344936

See all (24)

Prognosis

Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease.

Shen CR, Jia XY, Luo W, Olaru F, Cui Z, Zhao MH, Borza DB
J Am Soc Nephrol 2021 Aug;32(8):1887-1897. Epub 2021 Apr 23 doi: 10.1681/ASN.2020101431. PMID: 33893224 Free PMC Article

Induction of IgG(2) and IgG(4) B-cell memory following sublingual immunotherapy for ryegrass pollen allergy.

Heeringa JJ, McKenzie CI, Varese N, Hew M, Bakx ATCM, Aui PM, Rolland JM, O'Hehir RE, van Zelm MC
Allergy 2020 May;75(5):1121-1132. Epub 2019 Nov 4 doi: 10.1111/all.14073. PMID: 31587307 Free PMC Article

Association Between ApoA-I (Apolipoprotein A-I) Immune Complexes and Adverse Cardiovascular Events-Brief Report.

Henson D, Tahhan AS, Nardo D, Quyyumi AA, Venditto VJ
Arterioscler Thromb Vasc Biol 2019 Sep;39(9):1884-1892. Epub 2019 Jul 18 doi: 10.1161/ATVBAHA.119.312964. PMID: 31315438 Free PMC Article

Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.

von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAK
Front Immunol 2018;9:3035. Epub 2018 Dec 20 doi: 10.3389/fimmu.2018.03035. PMID: 30619370 Free PMC Article

The relationships among shrimp-specific IgG subclass antibodies and immediate adverse reactions to shrimp challenge.

Morgan JE, Daul CB, Lehrer SB
J Allergy Clin Immunol 1990 Sep;86(3 Pt 1):387-92. doi: 10.1016/s0091-6749(05)80102-2. PMID: 2212410

See all (17)

Clinical prediction guides

The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis.

Alcohol consumption alters anti-Strongyloides stercoralis antibodies production.

Induction of IgG(2) and IgG(4) B-cell memory following sublingual immunotherapy for ryegrass pollen allergy.

Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure.

van den Hoogen P, de Jager SCA, Huibers MMH, Schoneveld AH, Puspitasari YM, Valstar GB, Oerlemans MIFJ, de Weger RA, Doevendans PA, den Ruijter HM, Laman JD, Vink A, Sluijter JPG
J Cell Mol Med 2019 Nov;23(11):7505-7516. Epub 2019 Sep 26 doi: 10.1111/jcmm.14619. PMID: 31557411 Free PMC Article

Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.

von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAK
Front Immunol 2018;9:3035. Epub 2018 Dec 20 doi: 10.3389/fimmu.2018.03035. PMID: 30619370 Free PMC Article

See all (37)

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Increased circulating IgG subclass

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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