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Increased circulating IgG2 level

MedGen UID:
1704424
•Concept ID:
C5139256
•
Finding
HPO: HP:0032299

Definition

An abnormally increased concentration of the IgG2 subtype in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating IgG2 level

Conditions with this feature

Neutropenia, severe congenital, 11, autosomal dominant
MedGen UID:
1846394
•Concept ID:
C5882742
•
Disease or Syndrome
Autosomal dominant severe congenital neutropenia-11 (SCN11) is characterized by the onset of recurrent infections, mainly bacterial, in early childhood. Laboratory studies show severe neutropenia due to maturation arrest and impaired development of myeloid cells. Other leukocyte subsets, including B cells and NK cells, may also be subtly affected. Patients should be followed for possible renal dysfunction (Van Nieuwenhove et al., 2020). For discussion of genetic heterogeneity of severe congenital neutropenia, see SCN1 (202700).
See: Condition Record
Neutropenia, severe congenital, 11, autosomal dominant

Professional guidelines

PubMed

A 12-month follow-up of the immune response to SARS-CoV-2 primary vaccination: evidence from a real-world study.
Fedele G, Schiavoni I, Trentini F, Leone P, Olivetta E, Fallucca A, Fiore S, Di Martino A, Abrignani S, Baldo V, Baldovin T, Bandera A, Clerici P, De Paschale M, Diaco F, Domnich A, Fortunato F, Giberti I, Gori A, Grifantini R, Lazzarotto T, Lodi V, Mastroianni CM, Prato R, Restivo V, Vitale F, Brusaferro S, Merler S, Palamara AT, Stefanelli P; Study Group for the Immunological Monitoring post Covid19 vaccination
Front Immunol 2023;14:1272119. Epub 2023 Nov 20 doi: 10.3389/fimmu.2023.1272119. PMID: 38077369Free PMC Article
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Current drug treatment options in neonatal hyperbilirubinaemia and the prevention of kernicterus.
Rubaltelli FF
Drugs 1998 Jul;56(1):23-30. doi: 10.2165/00003495-199856010-00003. PMID: 9664196

Recent clinical studies

Etiology

Ofatumumab in Rituximab-Resistant and Rituximab-Intolerant Patients With Primary Membranous Nephropathy: A Case Series.
Podestà MA, Trillini M, Portalupi V, Gennarini A, Tomatis F, Villa A, Perna A, Rubis N, Remuzzi G, Ruggenenti P
Am J Kidney Dis 2024 Mar;83(3):340-349.e1. Epub 2023 Sep 29 doi: 10.1053/j.ajkd.2023.08.010. PMID: 37777061
Natural Antibodies Against Sialoglycans.
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Autoimmune hepatitis.
Mieli-Vergani G, Heller S, Jara P, Vergani D, Chang MH, Fujisawa T, González-Peralta RP, Kelly D, Mohan N, Shah U, Murray KF
J Pediatr Gastroenterol Nutr 2009 Aug;49(2):158-64. doi: 10.1097/MPG.0b013e3181a1c265. PMID: 19561543
Acquired inhibitors.
Cohen AJ, Kessler CM
Baillieres Clin Haematol 1996 Jun;9(2):331-54. doi: 10.1016/s0950-3536(96)80067-9. PMID: 8800509

Diagnosis

IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.
Aranda CJ, Gonzalez-Kozlova E, Saunders SP, Fernandes-Braga W, Ota M, Narayanan S, He JS, Del Duca E, Swaroop B, Gnjatic S, Shattner G, Reibman J, Soter NA, Guttman-Yassky E, Curotto de Lafaille MA
Allergy 2023 Mar;78(3):752-766. Epub 2022 Dec 19 doi: 10.1111/all.15601. PMID: 36445014Free PMC Article
Natural Antibodies Against Sialoglycans.
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Autoimmune hepatitis.
Mieli-Vergani G, Heller S, Jara P, Vergani D, Chang MH, Fujisawa T, González-Peralta RP, Kelly D, Mohan N, Shah U, Murray KF
J Pediatr Gastroenterol Nutr 2009 Aug;49(2):158-64. doi: 10.1097/MPG.0b013e3181a1c265. PMID: 19561543
Acquired inhibitors.
Cohen AJ, Kessler CM
Baillieres Clin Haematol 1996 Jun;9(2):331-54. doi: 10.1016/s0950-3536(96)80067-9. PMID: 8800509

Therapy

A multi-institutional study found a possible role of anti-nephrin antibodies in post-transplant focal segmental glomerulosclerosis recurrence.
Shirai Y, Miura K, Ishizuka K, Ando T, Kanda S, Hashimoto J, Hamasaki Y, Hotta K, Ito N, Honda K, Tanabe K, Takano T, Hattori M
Kidney Int 2024 Mar;105(3):608-617. Epub 2023 Dec 16 doi: 10.1016/j.kint.2023.11.022. PMID: 38110152
Ofatumumab in Rituximab-Resistant and Rituximab-Intolerant Patients With Primary Membranous Nephropathy: A Case Series.
Podestà MA, Trillini M, Portalupi V, Gennarini A, Tomatis F, Villa A, Perna A, Rubis N, Remuzzi G, Ruggenenti P
Am J Kidney Dis 2024 Mar;83(3):340-349.e1. Epub 2023 Sep 29 doi: 10.1053/j.ajkd.2023.08.010. PMID: 37777061
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Autoimmune hepatitis.
Mieli-Vergani G, Heller S, Jara P, Vergani D, Chang MH, Fujisawa T, González-Peralta RP, Kelly D, Mohan N, Shah U, Murray KF
J Pediatr Gastroenterol Nutr 2009 Aug;49(2):158-64. doi: 10.1097/MPG.0b013e3181a1c265. PMID: 19561543
Acquired inhibitors.
Cohen AJ, Kessler CM
Baillieres Clin Haematol 1996 Jun;9(2):331-54. doi: 10.1016/s0950-3536(96)80067-9. PMID: 8800509

Prognosis

Urinary Modified C-Reactive Protein is Closely Associated with Tubulointerstitial Lesions in Lupus Nephritis.
Yuan M, Liu XL, Tan Y, Yu F, Zhao MH
Mediators Inflamm 2023;2023:6107911. Epub 2023 Jul 28 doi: 10.1155/2023/6107911. PMID: 37545739Free PMC Article
Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity.
Vicente MM, Alves I, Gaifem J, Rodrigues CS, Fernandes Â, Dias AM, Štambuk J, Petrović T, Oliveira P, Ferreira-da-Silva F, Soares A, Seixas N, Teixeira T, Malheiro L, Abreu MM, Lauc G, Sarmento E Castro R, Pinho SS
Eur J Immunol 2022 Jun;52(6):946-957. Epub 2022 Apr 4 doi: 10.1002/eji.202149491. PMID: 35307819Free PMC Article
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Autoimmune hepatitis.
Mieli-Vergani G, Heller S, Jara P, Vergani D, Chang MH, Fujisawa T, González-Peralta RP, Kelly D, Mohan N, Shah U, Murray KF
J Pediatr Gastroenterol Nutr 2009 Aug;49(2):158-64. doi: 10.1097/MPG.0b013e3181a1c265. PMID: 19561543
Acquired inhibitors.
Cohen AJ, Kessler CM
Baillieres Clin Haematol 1996 Jun;9(2):331-54. doi: 10.1016/s0950-3536(96)80067-9. PMID: 8800509

Clinical prediction guides

A critical view on autoantibodies in lupus nephritis: Concrete knowledge based on evidence.
Bruschi M, Angeletti A, Prunotto M, Meroni PL, Ghiggeri GM; Zeus consortium, Moroni G, Sinico RA, Franceschini F, Fredi M, Vaglio A, Cavalli A, Scapozza L, Patel JJ, Tan JC, Lo KC, Cavagna L, Petretto A, Pratesi F, Migliorini P, Locatelli F, Pazzola G, Pesce G, Giannese D, Manfredi A, Ramirez GA, Esposito P, Murdaca G, Negrini S, Bui F, Trezzi B, Emmi G, Cavazzana I, Binda V, Fenaroli P, Pisan I, Montecucco C, Santoro D, Scolari F, Mescia F, Volpi S, Mosca M, Tincani A, Ravelli A, Murtas C, Candiano G, Caridi G, La Porta E, Verrina E
Autoimmun Rev 2024 May;23(5):103535. Epub 2024 Mar 27 doi: 10.1016/j.autrev.2024.103535. PMID: 38552995
Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients.
McQuiston A, Scott D, Nord D, Langerude L, Pelaez A, Machuca T, Mehta A, Drake RR, Christie JD, Angel P, Atkinson C
Transpl Immunol 2022 Apr;71:101491. Epub 2021 Nov 10 doi: 10.1016/j.trim.2021.101491. PMID: 34767945
Increased Circulating Th1 and Tfh1 Cell Numbers Are Associated with Disease Activity in Glucocorticoid-Treated Patients with IgG4-Related Disease.
Xia C, Liu C, Liu Y, Long Y, Xu L, Liu C
J Immunol Res 2020;2020:3757015. Epub 2020 Nov 27 doi: 10.1155/2020/3757015. PMID: 33313326Free PMC Article
Current Understanding and Unknown Aspects of the Treatment of Granulomatosis with Polyangiitis (Wegener's Granulomatosis): Opportunities for Future Studies.
Alesaeidi S, Darvishi M, Dabiri S, GhasemiAdl M, Jafarieh A, Tavakolpour S
Curr Rheumatol Rev 2020;16(4):257-266. doi: 10.2174/1573397116666200331130919. PMID: 32228425
Natural Antibodies Against Sialoglycans.
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491

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