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Locally Advanced Unresectable Colon Adenocarcinoma

MedGen UID:
1685944
•Concept ID:
C5206479
•
Neoplastic Process

Definition

A colon adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Colon Adenocarcinoma

Professional guidelines

PubMed

Therapy with pembrolizumab in treatment-naïve patients with nonmetastatic, mismatch repair deficient colorectal cancer.
Eefsen RL, Larsen JS, Klarskov LL, Altaf R, Høgdall E, Ingeholm P, Lykke J, Nielsen DL, Pfeiffer P, Poulsen LØ, Qvortrup C, Schou JV, Mau-Sørensen M, Østerlind K, Jensen BV
Int J Cancer 2023 May 15;152(10):2145-2152. Epub 2023 Jan 18 doi: 10.1002/ijc.34420. PMID: 36594580
Residual, recurrent, or unresectable gastrointestinal cancer. Role of radiation in single or combined modality treatment.
Gunderson LL, Martin JK, O'Connell MJ, Beart RW, Kvols LK, Nagorney DM
Cancer 1985 May 1;55(9 Suppl):2250-8. doi: 10.1002/1097-0142(19850501)55:9+<2250::aid-cncr2820551431>3.0.co;2-0. PMID: 3919929

Recent clinical studies

Etiology

Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study.
Strickler JH, Cercek A, Siena S, André T, Ng K, Van Cutsem E, Wu C, Paulson AS, Hubbard JM, Coveler AL, Fountzilas C, Kardosh A, Kasi PM, Lenz HJ, Ciombor KK, Elez E, Bajor DL, Cremolini C, Sanchez F, Stecher M, Feng W, Bekaii-Saab TS; MOUNTAINEER investigators
Lancet Oncol 2023 May;24(5):496-508. doi: 10.1016/S1470-2045(23)00150-X. PMID: 37142372
Oligometastatic Colorectal Cancer: A Review of Definitions and Patient Selection for Local Therapies.
Miller ED, Hitchcock KE, Romesser PB
J Gastrointest Cancer 2023 Dec;54(4):1116-1127. Epub 2023 Jan 18 doi: 10.1007/s12029-022-00900-5. PMID: 36652155Free PMC Article
Therapy with pembrolizumab in treatment-naïve patients with nonmetastatic, mismatch repair deficient colorectal cancer.
Eefsen RL, Larsen JS, Klarskov LL, Altaf R, Høgdall E, Ingeholm P, Lykke J, Nielsen DL, Pfeiffer P, Poulsen LØ, Qvortrup C, Schou JV, Mau-Sørensen M, Østerlind K, Jensen BV
Int J Cancer 2023 May 15;152(10):2145-2152. Epub 2023 Jan 18 doi: 10.1002/ijc.34420. PMID: 36594580
Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities.
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article
Neoadjuvant chemoradiotherapy in patients with unresectable locally advanced sigmoid colon cancer: clinical feasibility and outcome.
Niu SQ, Li RZ, Yuan Y, Xie WH, Wang QX, Chang H, Lu ZH, Ding PR, Li LR, Wu XJ, Zeng ZF, Xiao WW, Gao YH
Radiat Oncol 2021 May 24;16(1):93. doi: 10.1186/s13014-021-01823-4. PMID: 34030722Free PMC Article

Diagnosis

Prospective observational non-randomized trial protocol for surgical planner 3D image processing & reconstruction for locally advanced colon cancer.
Jerí-McFarlane S, García-Granero Á, Pellino G, Torres-Marí N, Ochogavía-Seguí A, Rodríguez-Velázquez M, Gamundí-Cuesta M, González-Argenté FX
BMC Surg 2024 Oct 7;24(1):292. doi: 10.1186/s12893-024-02558-1. PMID: 39375653Free PMC Article
Oligometastatic Colorectal Cancer: A Review of Definitions and Patient Selection for Local Therapies.
Miller ED, Hitchcock KE, Romesser PB
J Gastrointest Cancer 2023 Dec;54(4):1116-1127. Epub 2023 Jan 18 doi: 10.1007/s12029-022-00900-5. PMID: 36652155Free PMC Article
Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities.
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article
Neoadjuvant chemoradiotherapy for patients with unresectable radically locally advanced colon cancer: a potential improvement to overall survival and decrease to multivisceral resection.
Yuan Y, Xiao WW, Xie WH, Cai PQ, Wang QX, Chang H, Chen BQ, Zhou WH, Zeng ZF, Wu XJ, Liu Q, Li LR, Zhang R, Gao YH
BMC Cancer 2021 Feb 19;21(1):179. doi: 10.1186/s12885-021-07894-6. PMID: 33607964Free PMC Article
Therapy of gastrointestinal cancer.
Greig RG, Schein PS
Scand J Gastroenterol Suppl 1985;117:9-25. doi: 10.3109/00365528509092224. PMID: 3912966

Therapy

Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study.
Strickler JH, Cercek A, Siena S, André T, Ng K, Van Cutsem E, Wu C, Paulson AS, Hubbard JM, Coveler AL, Fountzilas C, Kardosh A, Kasi PM, Lenz HJ, Ciombor KK, Elez E, Bajor DL, Cremolini C, Sanchez F, Stecher M, Feng W, Bekaii-Saab TS; MOUNTAINEER investigators
Lancet Oncol 2023 May;24(5):496-508. doi: 10.1016/S1470-2045(23)00150-X. PMID: 37142372
Oligometastatic Colorectal Cancer: A Review of Definitions and Patient Selection for Local Therapies.
Miller ED, Hitchcock KE, Romesser PB
J Gastrointest Cancer 2023 Dec;54(4):1116-1127. Epub 2023 Jan 18 doi: 10.1007/s12029-022-00900-5. PMID: 36652155Free PMC Article
Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities.
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article
Neoadjuvant chemoradiotherapy in patients with unresectable locally advanced sigmoid colon cancer: clinical feasibility and outcome.
Niu SQ, Li RZ, Yuan Y, Xie WH, Wang QX, Chang H, Lu ZH, Ding PR, Li LR, Wu XJ, Zeng ZF, Xiao WW, Gao YH
Radiat Oncol 2021 May 24;16(1):93. doi: 10.1186/s13014-021-01823-4. PMID: 34030722Free PMC Article
Neoadjuvant chemoradiotherapy for patients with unresectable radically locally advanced colon cancer: a potential improvement to overall survival and decrease to multivisceral resection.
Yuan Y, Xiao WW, Xie WH, Cai PQ, Wang QX, Chang H, Chen BQ, Zhou WH, Zeng ZF, Wu XJ, Liu Q, Li LR, Zhang R, Gao YH
BMC Cancer 2021 Feb 19;21(1):179. doi: 10.1186/s12885-021-07894-6. PMID: 33607964Free PMC Article

Prognosis

Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study.
Abe S, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ozawa T, Yokoyama Y, Nagai Y, Anzai H, Sonoda H, Yamauchi S, Sugihara K, Ishihara S
BMC Cancer 2022 May 2;22(1):486. doi: 10.1186/s12885-022-09615-z. PMID: 35501727Free PMC Article
Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities.
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article
Neoadjuvant chemoradiotherapy in patients with unresectable locally advanced sigmoid colon cancer: clinical feasibility and outcome.
Niu SQ, Li RZ, Yuan Y, Xie WH, Wang QX, Chang H, Lu ZH, Ding PR, Li LR, Wu XJ, Zeng ZF, Xiao WW, Gao YH
Radiat Oncol 2021 May 24;16(1):93. doi: 10.1186/s13014-021-01823-4. PMID: 34030722Free PMC Article
Neoadjuvant chemoradiotherapy for patients with unresectable radically locally advanced colon cancer: a potential improvement to overall survival and decrease to multivisceral resection.
Yuan Y, Xiao WW, Xie WH, Cai PQ, Wang QX, Chang H, Chen BQ, Zhou WH, Zeng ZF, Wu XJ, Liu Q, Li LR, Zhang R, Gao YH
BMC Cancer 2021 Feb 19;21(1):179. doi: 10.1186/s12885-021-07894-6. PMID: 33607964Free PMC Article
Outcomes of preoperative chemoradiotherapy followed by surgery in patients with unresectable locally advanced sigmoid colon cancer.
Qiu B, Ding PR, Cai L, Xiao WW, Zeng ZF, Chen G, Lu ZH, Li LR, Wu XJ, Mirimanoff RO, Pan ZZ, Xu RH, Gao YH
Chin J Cancer 2016 Jul 7;35(1):65. doi: 10.1186/s40880-016-0126-y. PMID: 27389519Free PMC Article

Clinical prediction guides

Prospective observational non-randomized trial protocol for surgical planner 3D image processing & reconstruction for locally advanced colon cancer.
Jerí-McFarlane S, García-Granero Á, Pellino G, Torres-Marí N, Ochogavía-Seguí A, Rodríguez-Velázquez M, Gamundí-Cuesta M, González-Argenté FX
BMC Surg 2024 Oct 7;24(1):292. doi: 10.1186/s12893-024-02558-1. PMID: 39375653Free PMC Article
Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study.
Abe S, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ozawa T, Yokoyama Y, Nagai Y, Anzai H, Sonoda H, Yamauchi S, Sugihara K, Ishihara S
BMC Cancer 2022 May 2;22(1):486. doi: 10.1186/s12885-022-09615-z. PMID: 35501727Free PMC Article
Neoadjuvant chemoradiotherapy in patients with unresectable locally advanced sigmoid colon cancer: clinical feasibility and outcome.
Niu SQ, Li RZ, Yuan Y, Xie WH, Wang QX, Chang H, Lu ZH, Ding PR, Li LR, Wu XJ, Zeng ZF, Xiao WW, Gao YH
Radiat Oncol 2021 May 24;16(1):93. doi: 10.1186/s13014-021-01823-4. PMID: 34030722Free PMC Article
Neoadjuvant chemoradiotherapy for patients with unresectable radically locally advanced colon cancer: a potential improvement to overall survival and decrease to multivisceral resection.
Yuan Y, Xiao WW, Xie WH, Cai PQ, Wang QX, Chang H, Chen BQ, Zhou WH, Zeng ZF, Wu XJ, Liu Q, Li LR, Zhang R, Gao YH
BMC Cancer 2021 Feb 19;21(1):179. doi: 10.1186/s12885-021-07894-6. PMID: 33607964Free PMC Article
Outcomes of preoperative chemoradiotherapy followed by surgery in patients with unresectable locally advanced sigmoid colon cancer.
Qiu B, Ding PR, Cai L, Xiao WW, Zeng ZF, Chen G, Lu ZH, Li LR, Wu XJ, Mirimanoff RO, Pan ZZ, Xu RH, Gao YH
Chin J Cancer 2016 Jul 7;35(1):65. doi: 10.1186/s40880-016-0126-y. PMID: 27389519Free PMC Article

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