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Abnormal B cell subset distribution

MedGen UID:: 1371752
•Concept ID:: C4476839
•: Finding

HPO:	HP:0025539

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal B cell subset distribution

Abnormal immune system morphology
- Abnormal cellular immune system morphology
  - Abnormal leukocyte morphology
    - Abnormal leukocyte count
      - Abnormal lymphocyte count
        Abnormal B cell count
        Abnormal B cell subset distribution
        Abnormal plasmablast proportion
        Decreased proportion of plasmablasts
        Increased proportion of plasmablasts
        Abnormal proportion of immature B cells
        Decreased proportion of immature B cells
        Increased proportion of immature B cells
        Abnormal proportion of memory B cells
        Abnormal proportion of class-switched memory B cells
        Decreased proportion of class-switched memory B cells
        Increased proportion of class-switched memory B cells
        Abnormal proportion of marginal zone B cells
        Decreased proportion of marginal zone B cells
        Increased proportion of marginal zone B cells
        Abnormal proportion of unswitched memory B cells
        Decreased proportion of unswitched memory B cells
        Increased proportion of unswitched memory B cells
        Decreased proportion of memory B cells
        Increased proportion of memory B cells
        Abnormal proportion of naive B cells
        Decreased proportion of naive B cells
        Increased proportion of naive B cells
        Abnormal proportion of transitional B cells
        Decreased proportion of transitional B cells
        Increased proportion of transitional B cells
        Increased proportion autoreactive unresponsive CD21-/low B cells

Professional guidelines

PubMed

B lymphocytes are required for development and treatment of autoimmune diseases.

Youinou P, Jamin C, Pers JO, Berthou C, Saraux A, Renaudineau Y
Ann N Y Acad Sci 2005 Jun;1050:19-33. doi: 10.1196/annals.1313.003. PMID: 16014517

Recent clinical studies

Etiology

Correction of abnormal B-cell subset distribution by interleukin-6 receptor blockade in polymyalgia rheumatica.

Carvajal Alegria G, Devauchelle-Pensec V, Renaudineau Y, Saraux A, Pers JO, Cornec D
Rheumatology (Oxford) 2017 Aug 1;56(8):1401-1406. doi: 10.1093/rheumatology/kex169. PMID: 28431111

Diagnosis

Correction of abnormal B-cell subset distribution by interleukin-6 receptor blockade in polymyalgia rheumatica.

Carvajal Alegria G, Devauchelle-Pensec V, Renaudineau Y, Saraux A, Pers JO, Cornec D
Rheumatology (Oxford) 2017 Aug 1;56(8):1401-1406. doi: 10.1093/rheumatology/kex169. PMID: 28431111

Therapy

Correction of abnormal B-cell subset distribution by interleukin-6 receptor blockade in polymyalgia rheumatica.

Carvajal Alegria G, Devauchelle-Pensec V, Renaudineau Y, Saraux A, Pers JO, Cornec D
Rheumatology (Oxford) 2017 Aug 1;56(8):1401-1406. doi: 10.1093/rheumatology/kex169. PMID: 28431111

Clinical prediction guides

Correction of abnormal B-cell subset distribution by interleukin-6 receptor blockade in polymyalgia rheumatica.

Carvajal Alegria G, Devauchelle-Pensec V, Renaudineau Y, Saraux A, Pers JO, Cornec D
Rheumatology (Oxford) 2017 Aug 1;56(8):1401-1406. doi: 10.1093/rheumatology/kex169. PMID: 28431111

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Reviews

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