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Abnormal proportion of class-switched memory B cells

MedGen UID:: 892550
•Concept ID:: C4072924
•: Finding

Synonym:	Abnormal class-switched memory B cell count

HPO:	HP:0030386

Definition

A deviation of the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM-/IgD-) in circulation relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal proportion of class-switched memory B cells

Abnormal leukocyte morphology
- Abnormal leukocyte count
  - Abnormal lymphocyte count
    - Abnormal B cell count
      - Abnormal B cell subset distribution
        Abnormal proportion of memory B cells
        Abnormal proportion of class-switched memory B cells
        Decreased proportion of class-switched memory B cells
        Increased proportion of class-switched memory B cells

Recent clinical studies

Etiology

Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.

Miyazaki Y, Nakayamada S, Kubo S, Ishikawa Y, Yoshikawa M, Sakata K, Iwata S, Miyagawa I, Nakano K, Tanaka Y
Arthritis Res Ther 2020 Jun 15;22(1):141. doi: 10.1186/s13075-020-02215-x. PMID: 32539843 Free PMC Article

Peripheral Immunophenotyping Identifies Three Subgroups Based on T Cell Heterogeneity in Lupus Patients.

Kubo S, Nakayamada S, Yoshikawa M, Miyazaki Y, Sakata K, Nakano K, Hanami K, Iwata S, Miyagawa I, Saito K, Tanaka Y
Arthritis Rheumatol 2017 Oct;69(10):2029-2037. Epub 2017 Aug 25 doi: 10.1002/art.40180. PMID: 28605137

Recurrent respiratory infections, specific antibody deficiencies, and memory B cells.

Leiva LE, Monjure H, Sorensen RU
J Clin Immunol 2013 Jan;33 Suppl 1:S57-61. Epub 2012 Oct 24 doi: 10.1007/s10875-012-9814-9. PMID: 23093309

See all (3)

Diagnosis

Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.

Correlation of T follicular helper cells and plasmablasts with the development of organ involvement in patients with IgG4-related disease.

Kubo S, Nakayamada S, Zhao J, Yoshikawa M, Miyazaki Y, Nawata A, Hirata S, Nakano K, Saito K, Tanaka Y
Rheumatology (Oxford) 2018 Mar 1;57(3):514-524. doi: 10.1093/rheumatology/kex455. PMID: 29253269

See all (2)

Therapy

Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.

See all (1)

Prognosis

Recurrent respiratory infections, specific antibody deficiencies, and memory B cells.

Leiva LE, Monjure H, Sorensen RU
J Clin Immunol 2013 Jan;33 Suppl 1:S57-61. Epub 2012 Oct 24 doi: 10.1007/s10875-012-9814-9. PMID: 23093309

See all (1)

Clinical prediction guides

Human umbilical cord-derived mesenchymal stem cell transplantation improves the long COVID.

Tang Y, Zou X, Liu P, Dai Y, Wang S, Su X, Yu Y, Tang W, Zhou J, Li C, Mei H, Xiao N, Ou Y, Wang J, Lu G, Lin G, Cheng L
J Med Virol 2024 Jun;96(6):e29757. doi: 10.1002/jmv.29757. PMID: 38899432

Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.

Peripheral Immunophenotyping Identifies Three Subgroups Based on T Cell Heterogeneity in Lupus Patients.

See all (3)

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Abnormal proportion of class-switched memory B cells

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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