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Decreased proportion of plasmablasts

MedGen UID:
1697852
Concept ID:
C5139149
Finding
HPO: HP:0032129

Definition

A reduction below the normal proportion of plasmablasts in circulation relative to total number of B cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased proportion of plasmablasts

Recent clinical studies

Etiology

Guo F, Pan Q, Chen T, Liao S, Li S, Li A, Chen S, Chen J, Xiao Z, Su H, Yang L, Yang C, Liu HF, Pan Q
Stem Cell Res Ther 2023 Aug 21;14(1):211. doi: 10.1186/s13287-023-03432-2. PMID: 37605271Free PMC Article
Wang M, Jiang R, Mohanty S, Meng H, Shaw AC, Kleinstein SH
Aging (Albany NY) 2023 Jun 26;15(18):9250-9274. doi: 10.18632/aging.204778. PMID: 37367734Free PMC Article
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Fernández-Velasco JI, Kuhle J, Monreal E, Meca-Lallana V, Meca-Lallana J, Izquierdo G, Gascón-Giménez F, Sainz de la Maza S, Walo-Delgado PE, Maceski A, Rodríguez-Martín E, Roldán E, Villarrubia N, Saiz A, Blanco Y, Sánchez P, Carreón-Guarnizo E, Aladro Y, Brieva L, Íñiguez C, González-Suárez I, Rodríguez de Antonio LA, Masjuan J, Costa-Frossard L, Villar LM
Neurol Neuroimmunol Neuroinflamm 2021 Mar 4;8(2) Epub 2021 Jan 6 doi: 10.1212/NXI.0000000000000940. PMID: 33408167Free PMC Article
Oniszczuk J, Beldi-Ferchiou A, Audureau E, Azzaoui I, Molinier-Frenkel V, Frontera V, Karras A, Moktefi A, Pillebout E, Zaidan M, El Karoui K, Delfau-Larue MH, Hénique C, Ollero M, Sahali D, Mahévas M, Audard V
Nephrol Dial Transplant 2021 Mar 29;36(4):609-617. doi: 10.1093/ndt/gfaa279. PMID: 33241414

Diagnosis

Bahabayi A, Guan Z, Zheng M, Yu H, Hasimu A, Nie Y, Zhao M, Zhu Y, Ren J, Zhao Y, Ma X, Li Q, Zhang Z, Zeng X, Liu C
Immunology 2024 Sep;173(1):172-184. Epub 2024 Jun 5 doi: 10.1111/imm.13819. PMID: 38840413
Zhang Z, Huang X, Du X, Wang Z, Wang Y, Xu M, Chen X, Yao Q, Yan L, Zhang Y
J Neurochem 2023 Jun;165(6):907-919. Epub 2023 May 19 doi: 10.1111/jnc.15837. PMID: 37158660
Ye Q, Zhou C, Li S, Wang J, Liu F, Liu Z, Mao J, Fu H
Sci Rep 2021 Jun 22;11(1):13083. doi: 10.1038/s41598-021-92573-6. PMID: 34158604Free PMC Article
Oniszczuk J, Beldi-Ferchiou A, Audureau E, Azzaoui I, Molinier-Frenkel V, Frontera V, Karras A, Moktefi A, Pillebout E, Zaidan M, El Karoui K, Delfau-Larue MH, Hénique C, Ollero M, Sahali D, Mahévas M, Audard V
Nephrol Dial Transplant 2021 Mar 29;36(4):609-617. doi: 10.1093/ndt/gfaa279. PMID: 33241414
Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327Free PMC Article

Therapy

Perugino CA, Wallace ZS, Zack DJ, Quinn SM, Poma A, Fernandes AD, Foster P, DeMattos S, Burington B, Liu H, Allard-Chamard H, Smith N, Kai X, Xing K, Pillai S, Stone JH
Lancet Rheumatol 2023 Aug;5(8):e442-e450. Epub 2023 Jul 24 doi: 10.1016/S2665-9913(23)00157-1. PMID: 38251576
Raqib R, Akhtar E, Ahsanul Haq M, Ahmed S, Haque F, Chowdhury MAH, Shahriar MH, Begum BA, Eunus M, Sarwar G, Parvez F, Sharker Y, Ahsan H, Yunus M
Environ Int 2023 Sep;179:108137. Epub 2023 Aug 9 doi: 10.1016/j.envint.2023.108137. PMID: 37579572Free PMC Article
Merrill JT, Guthridge J, Smith M, June J, Koumpouras F, Machua W, Askanase A, Khosroshahi A, Sheikh SZ, Rathi G, Burington B, Foster P, Matijevic M, Arora S, Wang X, Gao M, Wax S, James JA, Zack DJ
Arthritis Rheumatol 2023 Dec;75(12):2185-2194. doi: 10.1002/art.42652. PMID: 37459248
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Fernández-Velasco JI, Kuhle J, Monreal E, Meca-Lallana V, Meca-Lallana J, Izquierdo G, Gascón-Giménez F, Sainz de la Maza S, Walo-Delgado PE, Maceski A, Rodríguez-Martín E, Roldán E, Villarrubia N, Saiz A, Blanco Y, Sánchez P, Carreón-Guarnizo E, Aladro Y, Brieva L, Íñiguez C, González-Suárez I, Rodríguez de Antonio LA, Masjuan J, Costa-Frossard L, Villar LM
Neurol Neuroimmunol Neuroinflamm 2021 Mar 4;8(2) Epub 2021 Jan 6 doi: 10.1212/NXI.0000000000000940. PMID: 33408167Free PMC Article

Prognosis

Zhang Z, Huang X, Du X, Wang Z, Wang Y, Xu M, Chen X, Yao Q, Yan L, Zhang Y
J Neurochem 2023 Jun;165(6):907-919. Epub 2023 May 19 doi: 10.1111/jnc.15837. PMID: 37158660
Kopitar AN, Repas J, Janžič L, Bizjak M, Vesel TT, Emeršič N, Avramovič MZ, Ihan A, Avčin T, Pavlin M
Front Immunol 2023;14:1157702. Epub 2023 Apr 20 doi: 10.3389/fimmu.2023.1157702. PMID: 37153551Free PMC Article
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Nakayamada S, Kubo S, Yoshikawa M, Miyazaki Y, Yunoue N, Iwata S, Miyagawa I, Hirata S, Nakano K, Saito K, Tanaka Y
Rheumatology (Oxford) 2018 Jan 1;57(1):164-174. doi: 10.1093/rheumatology/kex012. PMID: 28371836

Clinical prediction guides

Perugino CA, Wallace ZS, Zack DJ, Quinn SM, Poma A, Fernandes AD, Foster P, DeMattos S, Burington B, Liu H, Allard-Chamard H, Smith N, Kai X, Xing K, Pillai S, Stone JH
Lancet Rheumatol 2023 Aug;5(8):e442-e450. Epub 2023 Jul 24 doi: 10.1016/S2665-9913(23)00157-1. PMID: 38251576
Bao W, Xie M, Ye Y
Cell Immunol 2022 Jul;377:104533. Epub 2022 May 6 doi: 10.1016/j.cellimm.2022.104533. PMID: 35594728
Yu TS, Wang HY, Zhao YJ, Yu YF, Hou Y, Liu S, Han PP, Ni XF, Ji XB, Peng J, Liu XG, Hou M
Blood Adv 2021 Oct 26;5(20):4087-4101. doi: 10.1182/bloodadvances.2020003860. PMID: 34507351Free PMC Article
Brod SA
Mult Scler Relat Disord 2021 Jul;52:102971. Epub 2021 May 4 doi: 10.1016/j.msard.2021.102971. PMID: 33992916
Fernández-Velasco JI, Kuhle J, Monreal E, Meca-Lallana V, Meca-Lallana J, Izquierdo G, Gascón-Giménez F, Sainz de la Maza S, Walo-Delgado PE, Maceski A, Rodríguez-Martín E, Roldán E, Villarrubia N, Saiz A, Blanco Y, Sánchez P, Carreón-Guarnizo E, Aladro Y, Brieva L, Íñiguez C, González-Suárez I, Rodríguez de Antonio LA, Masjuan J, Costa-Frossard L, Villar LM
Neurol Neuroimmunol Neuroinflamm 2021 Mar 4;8(2) Epub 2021 Jan 6 doi: 10.1212/NXI.0000000000000940. PMID: 33408167Free PMC Article

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