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Abnormal proportion of memory B cells

MedGen UID:
893043
•Concept ID:
C4072912
•
Finding
Synonym: Abnormal memory B cell count
 
HPO: HP:0030373

Definition

A deviation of the normal proportion of memory B cells in circulation relative to total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV). [from HPO]

Professional guidelines

PubMed

Protein-losing Enteropathy as a Complication and/or Differential Diagnosis of Common Variable Immunodeficiency.
Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255

Recent clinical studies

Etiology

Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state.
Zheng J, Zhu L, Ju B, Zhang J, Luo J, Wang Y, Lv X, Pu D, He L, Wang J
Clin Immunol 2022 Dec;245:109166. Epub 2022 Oct 19 doi: 10.1016/j.clim.2022.109166. PMID: 36270468
Elevated proportion of TLR2- and TLR4-expressing Th17-like cells and activated memory B cells was associated with clinical activity of cerebral cavernous malformations.
Castro C, Oyamada HAA, Cafasso MOSD, Lopes LM, Monteiro C, Sacramento PM, Alves-Leon SV, da Fontoura Galvão G, Hygino J, de Souza JPBM, Bento CAM
J Neuroinflammation 2022 Feb 2;19(1):28. doi: 10.1186/s12974-022-02385-2. PMID: 35109870Free PMC Article
Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs.
Framme JL, Lundqvist C, Lundell AC, van Schouwenburg PA, Lemarquis AL, Thörn K, Lindgren S, Gudmundsdottir J, Lundberg V, Degerman S, Zetterström RH, Borte S, Hammarström L, Telemo E, Hultdin M, van der Burg M, Fasth A, Oskarsdóttir S, Ekwall O
J Clin Immunol 2022 Apr;42(3):618-633. Epub 2022 Jan 26 doi: 10.1007/s10875-021-01201-5. PMID: 35080750Free PMC Article
Altered B lymphocyte homeostasis and functions in systemic sclerosis.
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447
Abatacept reduces levels of switched memory B cells, autoantibodies, and immunoglobulins in patients with rheumatoid arthritis.
Scarsi M, Paolini L, Ricotta D, Pedrini A, Piantoni S, Caimi L, Tincani A, Airò P
J Rheumatol 2014 Apr;41(4):666-72. Epub 2014 Mar 1 doi: 10.3899/jrheum.130905. PMID: 24584924

Diagnosis

Protein-losing Enteropathy as a Complication and/or Differential Diagnosis of Common Variable Immunodeficiency.
Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255
Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs.
Framme JL, Lundqvist C, Lundell AC, van Schouwenburg PA, Lemarquis AL, Thörn K, Lindgren S, Gudmundsdottir J, Lundberg V, Degerman S, Zetterström RH, Borte S, Hammarström L, Telemo E, Hultdin M, van der Burg M, Fasth A, Oskarsdóttir S, Ekwall O
J Clin Immunol 2022 Apr;42(3):618-633. Epub 2022 Jan 26 doi: 10.1007/s10875-021-01201-5. PMID: 35080750Free PMC Article
Alterations of peripheral blood B cell subsets in Chinese patients with adult idiopathic inflammatory myopathies.
Wang Y, Zhu L, Ju B, Luo J, Li Q, Lv X, Pu D, Hao Z, Wang J, He L
Clin Exp Rheumatol 2022 Feb;40(2):260-266. Epub 2021 Dec 10 doi: 10.55563/clinexprheumatol/ohsmuj. PMID: 34905483
Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.
Miyazaki Y, Nakayamada S, Kubo S, Ishikawa Y, Yoshikawa M, Sakata K, Iwata S, Miyagawa I, Nakano K, Tanaka Y
Arthritis Res Ther 2020 Jun 15;22(1):141. doi: 10.1186/s13075-020-02215-x. PMID: 32539843Free PMC Article
Correlation of T follicular helper cells and plasmablasts with the development of organ involvement in patients with IgG4-related disease.
Kubo S, Nakayamada S, Zhao J, Yoshikawa M, Miyazaki Y, Nawata A, Hirata S, Nakano K, Saito K, Tanaka Y
Rheumatology (Oxford) 2018 Mar 1;57(3):514-524. doi: 10.1093/rheumatology/kex455. PMID: 29253269

Therapy

The changes of intestinal flora and its relevance with memory Tfh and B cells in rheumatoid arthritis patients treated with csDMARDs and csDMARDs + bDMARDs.
Jiang C, Chi S, Wang F, Zhao C, Yang X, Liu M, Ma B, Chen J, Su C, Duan X
Immunobiology 2024 May;229(3):152798. Epub 2024 Mar 21 doi: 10.1016/j.imbio.2024.152798. PMID: 38537424
Baicalein alleviates fibrosis and inflammation in systemic sclerosis by regulating B-cell abnormalities.
Peng B, Hu Q, He R, Hou H, Lian D, Chen Y, Li H, Song L, Gao Y, Chen T, Zhang G, Li J
BMC Complement Med Ther 2023 Feb 21;23(1):62. doi: 10.1186/s12906-023-03885-1. PMID: 36810081Free PMC Article
Efficacy of tocilizumab therapy in a patient with severe pancytopenia associated with a STAT3 gain-of-function mutation.
Wang W, Liu L, Hui X, Wang Y, Ying W, Zhou Q, Hou J, Yang M, Sun B, Sun J, Wang X
BMC Immunol 2021 Mar 17;22(1):19. doi: 10.1186/s12865-021-00411-1. PMID: 33731004Free PMC Article
Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.
Miyazaki Y, Nakayamada S, Kubo S, Ishikawa Y, Yoshikawa M, Sakata K, Iwata S, Miyagawa I, Nakano K, Tanaka Y
Arthritis Res Ther 2020 Jun 15;22(1):141. doi: 10.1186/s13075-020-02215-x. PMID: 32539843Free PMC Article
Abatacept reduces levels of switched memory B cells, autoantibodies, and immunoglobulins in patients with rheumatoid arthritis.
Scarsi M, Paolini L, Ricotta D, Pedrini A, Piantoni S, Caimi L, Tincani A, Airò P
J Rheumatol 2014 Apr;41(4):666-72. Epub 2014 Mar 1 doi: 10.3899/jrheum.130905. PMID: 24584924

Prognosis

Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs.
Framme JL, Lundqvist C, Lundell AC, van Schouwenburg PA, Lemarquis AL, Thörn K, Lindgren S, Gudmundsdottir J, Lundberg V, Degerman S, Zetterström RH, Borte S, Hammarström L, Telemo E, Hultdin M, van der Burg M, Fasth A, Oskarsdóttir S, Ekwall O
J Clin Immunol 2022 Apr;42(3):618-633. Epub 2022 Jan 26 doi: 10.1007/s10875-021-01201-5. PMID: 35080750Free PMC Article
B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis.
Cardoso CC, Matiollo C, Pereira CHJ, Fonseca JS, Alves HEL, Silva OMD, Menegassi VS, Schiavon LL, Santos-Silva MC
Clin Res Hepatol Gastroenterol 2021 Jul;45(4):101698. Epub 2021 Apr 20 doi: 10.1016/j.clinre.2021.101698. PMID: 33852953
Abatacept reduces levels of switched memory B cells, autoantibodies, and immunoglobulins in patients with rheumatoid arthritis.
Scarsi M, Paolini L, Ricotta D, Pedrini A, Piantoni S, Caimi L, Tincani A, Airò P
J Rheumatol 2014 Apr;41(4):666-72. Epub 2014 Mar 1 doi: 10.3899/jrheum.130905. PMID: 24584924
Recurrent respiratory infections, specific antibody deficiencies, and memory B cells.
Leiva LE, Monjure H, Sorensen RU
J Clin Immunol 2013 Jan;33 Suppl 1:S57-61. Epub 2012 Oct 24 doi: 10.1007/s10875-012-9814-9. PMID: 23093309

Clinical prediction guides

Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Elevated proportion of TLR2- and TLR4-expressing Th17-like cells and activated memory B cells was associated with clinical activity of cerebral cavernous malformations.
Castro C, Oyamada HAA, Cafasso MOSD, Lopes LM, Monteiro C, Sacramento PM, Alves-Leon SV, da Fontoura Galvão G, Hygino J, de Souza JPBM, Bento CAM
J Neuroinflammation 2022 Feb 2;19(1):28. doi: 10.1186/s12974-022-02385-2. PMID: 35109870Free PMC Article
Loss of immune homeostasis in patients with idiopathic pulmonary arterial hypertension.
Heukels P, Corneth OBJ, van Uden D, van Hulst JAC, van den Toorn LM, van den Bosch AE, Wijsenbeek MS, Boomars KA, Kool M, Hendriks RW
Thorax 2021 Dec;76(12):1209-1218. Epub 2021 May 7 doi: 10.1136/thoraxjnl-2020-215460. PMID: 33963088Free PMC Article
B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis.
Cardoso CC, Matiollo C, Pereira CHJ, Fonseca JS, Alves HEL, Silva OMD, Menegassi VS, Schiavon LL, Santos-Silva MC
Clin Res Hepatol Gastroenterol 2021 Jul;45(4):101698. Epub 2021 Apr 20 doi: 10.1016/j.clinre.2021.101698. PMID: 33852953
Altered B lymphocyte homeostasis and functions in systemic sclerosis.
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447

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