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Degenerative disease of the central nervous system

MedGen UID:
124363
Concept ID:
C0270715
Disease or Syndrome
Synonym: Degenerative Diseases, Central Nervous System
SNOMED CT: Degenerative disease of the central nervous system (80690008)

Definition

A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDegenerative disease of the central nervous system

Professional guidelines

PubMed

Wang Y, Wang J, Feng J
Autoimmun Rev 2023 Nov;22(11):103449. Epub 2023 Sep 21 doi: 10.1016/j.autrev.2023.103449. PMID: 37741528
Mariottini A, De Matteis E, Cencioni MT, Muraro PA
Curr Neurol Neurosci Rep 2023 Sep;23(9):507-520. Epub 2023 Aug 17 doi: 10.1007/s11910-023-01290-2. PMID: 37589918Free PMC Article
Hua KY, Zhao WJ
Folia Neuropathol 2023;61(1):8-15. doi: 10.5114/fn.2022.119778. PMID: 37114956

Recent clinical studies

Etiology

Mariottini A, De Matteis E, Cencioni MT, Muraro PA
Curr Neurol Neurosci Rep 2023 Sep;23(9):507-520. Epub 2023 Aug 17 doi: 10.1007/s11910-023-01290-2. PMID: 37589918Free PMC Article
Charabati M, Wheeler MA, Weiner HL, Quintana FJ
Cell 2023 Mar 30;186(7):1309-1327. doi: 10.1016/j.cell.2023.03.008. PMID: 37001498Free PMC Article
Yang J, Guo Q, Zou X, Wang M, Wen Y, Chen X, Weng X, Xu F
CNS Neurosci Ther 2022 Feb;28(2):218-225. Epub 2021 Nov 10 doi: 10.1111/cns.13753. PMID: 34758102Free PMC Article
Yuan CL, Yi R, Dong Q, Yao LF, Liu B
Acta Neurol Belg 2021 Oct;121(5):1101-1110. Epub 2021 Apr 24 doi: 10.1007/s13760-021-01676-4. PMID: 33893981
Yadav SK, Mindur JE, Ito K, Dhib-Jalbut S
Curr Opin Neurol 2015 Jun;28(3):206-19. doi: 10.1097/WCO.0000000000000205. PMID: 25887768

Diagnosis

Hua KY, Zhao WJ
Folia Neuropathol 2023;61(1):8-15. doi: 10.5114/fn.2022.119778. PMID: 37114956
Yang J, Guo Q, Zou X, Wang M, Wen Y, Chen X, Weng X, Xu F
CNS Neurosci Ther 2022 Feb;28(2):218-225. Epub 2021 Nov 10 doi: 10.1111/cns.13753. PMID: 34758102Free PMC Article
Yuan CL, Yi R, Dong Q, Yao LF, Liu B
Acta Neurol Belg 2021 Oct;121(5):1101-1110. Epub 2021 Apr 24 doi: 10.1007/s13760-021-01676-4. PMID: 33893981
Expert Panel on Neurological Imaging, Moonis G, Subramaniam RM, Trofimova A, Burns J, Bykowski J, Chakraborty S, Holloway K, Ledbetter LN, Lee RK, Pannell JS, Pollock JM, Powers WJ, Roca RP, Rosenow JM, Shih RY, Utukuri PS, Corey AS
J Am Coll Radiol 2020 May;17(5S):S100-S112. doi: 10.1016/j.jacr.2020.01.040. PMID: 32370954
Domingues RB, Fernandes GBP, Leite FBVM, Senne C
Arq Neuropsiquiatr 2019 Jul 15;77(6):436-441. doi: 10.1590/0004-282X20190060. PMID: 31314847

Therapy

Peng Y, Chen Q, Xue YH, Jin H, Liu S, Du MQ, Yao SY
Am J Chin Med 2024;52(3):625-666. Epub 2024 Apr 24 doi: 10.1142/S0192415X24500277. PMID: 38654507
Mariottini A, De Matteis E, Cencioni MT, Muraro PA
Curr Neurol Neurosci Rep 2023 Sep;23(9):507-520. Epub 2023 Aug 17 doi: 10.1007/s11910-023-01290-2. PMID: 37589918Free PMC Article
Hua KY, Zhao WJ
Folia Neuropathol 2023;61(1):8-15. doi: 10.5114/fn.2022.119778. PMID: 37114956
Chen H, Deng C, Meng Z, Meng S
Front Biosci (Landmark Ed) 2022 Nov 25;27(11):312. doi: 10.31083/j.fbl2711312. PMID: 36472107
Vidal-Jordana A, Montalban X
Neuroimaging Clin N Am 2017 May;27(2):195-204. doi: 10.1016/j.nic.2016.12.001. PMID: 28391781

Prognosis

Wang Y, Wang J, Feng J
Autoimmun Rev 2023 Nov;22(11):103449. Epub 2023 Sep 21 doi: 10.1016/j.autrev.2023.103449. PMID: 37741528
Mariottini A, De Matteis E, Cencioni MT, Muraro PA
Curr Neurol Neurosci Rep 2023 Sep;23(9):507-520. Epub 2023 Aug 17 doi: 10.1007/s11910-023-01290-2. PMID: 37589918Free PMC Article
Hua KY, Zhao WJ
Folia Neuropathol 2023;61(1):8-15. doi: 10.5114/fn.2022.119778. PMID: 37114956
Yuan CL, Yi R, Dong Q, Yao LF, Liu B
Acta Neurol Belg 2021 Oct;121(5):1101-1110. Epub 2021 Apr 24 doi: 10.1007/s13760-021-01676-4. PMID: 33893981
Vidal-Jordana A, Montalban X
Neuroimaging Clin N Am 2017 May;27(2):195-204. doi: 10.1016/j.nic.2016.12.001. PMID: 28391781

Clinical prediction guides

Hu ZL, Yuan YQ, Tong Z, Liao MQ, Yuan SL, Jian Y, Yang JL, Liu WF
Mol Neurobiol 2023 Dec;60(12):6852-6868. Epub 2023 Jul 28 doi: 10.1007/s12035-023-03529-y. PMID: 37507575
Nociti V, Romozzi M
Int J Mol Sci 2023 May 8;24(9) doi: 10.3390/ijms24098447. PMID: 37176155Free PMC Article
Wang Y, Wang H, Xu H, Zheng Z, Meng Z, Xu Z, Li J, Xue M
Chem Biol Drug Des 2022 Oct;100(4):534-552. Epub 2022 May 30 doi: 10.1111/cbdd.14067. PMID: 35569008
Yuan CL, Yi R, Dong Q, Yao LF, Liu B
Acta Neurol Belg 2021 Oct;121(5):1101-1110. Epub 2021 Apr 24 doi: 10.1007/s13760-021-01676-4. PMID: 33893981
Schmierer K, McDowell A, Petrova N, Carassiti D, Thomas DL, Miquel ME
Neuroimage 2018 Nov 15;182:251-258. Epub 2018 Jan 31 doi: 10.1016/j.neuroimage.2018.01.052. PMID: 29373838

Recent systematic reviews

Matthews PM, Gupta D, Mittal D, Bai W, Scalfari A, Pollock KG, Sharma V, Hill N
Mult Scler Relat Disord 2023 Jun;74:104714. Epub 2023 Apr 9 doi: 10.1016/j.msard.2023.104714. PMID: 37068369
Wang Y, Wang N, Xu Z, Liu S, Liang X, Zhang Y, Jin X
J Ethnopharmacol 2023 Jun 12;309:116208. Epub 2023 Jan 31 doi: 10.1016/j.jep.2023.116208. PMID: 36731808
Elkjaer ML, Röttger R, Baumbach J, Illes Z
Front Immunol 2022;13:761225. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.761225. PMID: 35309325Free PMC Article
Webb EJD, Meads D, Eskyte I, King N, Dracup N, Chataway J, Ford HL, Marti J, Pavitt SH, Schmierer K, Manzano A
Patient 2018 Aug;11(4):391-402. doi: 10.1007/s40271-017-0296-y. PMID: 29313265

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