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Senile dementia

MedGen UID:
8279
•Concept ID:
C0011268
•
Mental or Behavioral Dysfunction
Synonyms: SD - Senile dementia; Senile Dementia
SNOMED CT: SD - Senile dementia (15662003); Senile dementia (15662003)

Definition

Loss of intellectual abilities in an elderly person, interfering with this person''s activities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSenile dementia

Professional guidelines

PubMed

Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs.
Thakral S, Yadav A, Singh V, Kumar M, Kumar P, Narang R, Sudhakar K, Verma A, Khalilullah H, Jaremko M, Emwas AH
Ageing Res Rev 2023 Jul;88:101960. Epub 2023 May 22 doi: 10.1016/j.arr.2023.101960. PMID: 37224884
Current study on diagnosis and treatment of Alzheimer's disease by targeting amyloid b-protein.
Hua KY, Zhao WJ
Folia Neuropathol 2023;61(1):8-15. doi: 10.5114/fn.2022.119778. PMID: 37114956
Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review.
Twarowski B, Herbet M
Int J Mol Sci 2023 Mar 30;24(7) doi: 10.3390/ijms24076518. PMID: 37047492Free PMC Article

Recent clinical studies

Etiology

What is Alzheimer's disease? An analysis of nosological perspectives from the 20th and 21st centuries.
Villain N, Michalon R
Eur J Neurol 2024 Nov;31(11):e16302. Epub 2024 Apr 15 doi: 10.1111/ene.16302. PMID: 38618742Free PMC Article

Diagnosis

What is Alzheimer's disease? An analysis of nosological perspectives from the 20th and 21st centuries.
Villain N, Michalon R
Eur J Neurol 2024 Nov;31(11):e16302. Epub 2024 Apr 15 doi: 10.1111/ene.16302. PMID: 38618742Free PMC Article

Therapy

Vaccines and Dementia: Part II. Efficacy of BCG and Other Vaccines Against Dementia.
Greenblatt CL, Lathe R
J Alzheimers Dis 2024;98(2):361-372. doi: 10.3233/JAD-231323. PMID: 38393913Free PMC Article
Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs.
Thakral S, Yadav A, Singh V, Kumar M, Kumar P, Narang R, Sudhakar K, Verma A, Khalilullah H, Jaremko M, Emwas AH
Ageing Res Rev 2023 Jul;88:101960. Epub 2023 May 22 doi: 10.1016/j.arr.2023.101960. PMID: 37224884
The Neuroprotective Potentiality of Flavonoids on Alzheimer's Disease.
Calderaro A, Patanè GT, Tellone E, Barreca D, Ficarra S, Misiti F, Laganà G
Int J Mol Sci 2022 Nov 27;23(23) doi: 10.3390/ijms232314835. PMID: 36499159Free PMC Article
Naftidrofuryl for dementia.
Lu D, Song H, Hao Z, Wu T, McCleery J
Cochrane Database Syst Rev 2011 Dec 7;(12):CD002955. doi: 10.1002/14651858.CD002955.pub4. PMID: 22161372
Formaldehyde stress.
He R, Lu J, Miao J
Sci China Life Sci 2010 Dec;53(12):1399-404. Epub 2010 Dec 23 doi: 10.1007/s11427-010-4112-3. PMID: 21181340

Prognosis

Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs.
Thakral S, Yadav A, Singh V, Kumar M, Kumar P, Narang R, Sudhakar K, Verma A, Khalilullah H, Jaremko M, Emwas AH
Ageing Res Rev 2023 Jul;88:101960. Epub 2023 May 22 doi: 10.1016/j.arr.2023.101960. PMID: 37224884
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Molecular and Cellular Basis of Neurodegeneration in Alzheimer's Disease.
Jeong S
Mol Cells 2017 Sep 30;40(9):613-620. Epub 2017 Sep 20 doi: 10.14348/molcells.2017.0096. PMID: 28927263Free PMC Article
Mutations, associated with early-onset Alzheimer's disease, discovered in Asian countries.
Bagyinszky E, Youn YC, An SS, Kim S
Clin Interv Aging 2016;11:1467-1488. Epub 2016 Oct 17 doi: 10.2147/CIA.S116218. PMID: 27799753Free PMC Article
Senile dementia.
Terry RD
Fed Proc 1978 Dec;37(14):2837-40. PMID: 720637

Clinical prediction guides

Macroscopic findings of brain with dementia.
Hashizume Y
Neuropathology 2022 Oct;42(5):353-366. Epub 2022 Apr 21 doi: 10.1111/neup.12785. PMID: 35451141
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Molecular and Cellular Basis of Neurodegeneration in Alzheimer's Disease.
Jeong S
Mol Cells 2017 Sep 30;40(9):613-620. Epub 2017 Sep 20 doi: 10.14348/molcells.2017.0096. PMID: 28927263Free PMC Article
Mutations, associated with early-onset Alzheimer's disease, discovered in Asian countries.
Bagyinszky E, Youn YC, An SS, Kim S
Clin Interv Aging 2016;11:1467-1488. Epub 2016 Oct 17 doi: 10.2147/CIA.S116218. PMID: 27799753Free PMC Article
Community-based geriatric assessment.
Martin DC, Morycz RK, McDowell BJ, Snustad D, Karpf M
J Am Geriatr Soc 1985 Sep;33(9):602-6. doi: 10.1111/j.1532-5415.1985.tb06316.x. PMID: 4031338

Recent systematic reviews

Mortality rate of pulmonary infection in senile dementia patients: A systematic review and meta-analysis.
Yao J, Liu S, Chen Q
Medicine (Baltimore) 2024 Sep 20;103(38):e39816. doi: 10.1097/MD.0000000000039816. PMID: 39312341Free PMC Article
Can the retina be used to diagnose and plot the progression of Alzheimer's disease?
Mahajan D, Votruba M
Acta Ophthalmol 2017 Dec;95(8):768-777. Epub 2017 Jun 9 doi: 10.1111/aos.13472. PMID: 29220126
Estimating the burden of early onset dementia; systematic review of disease prevalence.
Lambert MA, Bickel H, Prince M, Fratiglioni L, Von Strauss E, Frydecka D, Kiejna A, Georges J, Reynish EL
Eur J Neurol 2014 Apr;21(4):563-9. Epub 2014 Jan 13 doi: 10.1111/ene.12325. PMID: 24418291
Naftidrofuryl for dementia.
Lu D, Song H, Hao Z, Wu T, McCleery J
Cochrane Database Syst Rev 2011 Dec 7;(12):CD002955. doi: 10.1002/14651858.CD002955.pub4. PMID: 22161372
Validation therapy for dementia.
Neal M, Briggs M
Cochrane Database Syst Rev 2000;(2):CD001394. doi: 10.1002/14651858.CD001394. PMID: 10796644

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