Acquired Creutzfeldt-Jakob disease

MedGen UID:: 1826177
•Concept ID:: C5681100
•: Disease or Syndrome

Synonyms:	acquired CJD; acquired Creutzfeldt Jacob disease; acquired Creutzfeldt-Jakob disease; sporadic CJD
Modes of inheritance:	Not genetically inherited MedGen UID: 988794 •Concept ID: CN307044 • Finding Source: Orphanet clinical entity without genetic inheritance. See: This record Not genetically inherited (Orphanet)

Monarch Initiative:	MONDO:0018686
Orphanet:	ORPHA454700

Definition

A group of human prion diseases characterized by progressive, invariably fatal neurodegeneration resulting from accidental transmission of prions. The group comprises iatrogenic Creutzfeldt-Jakob disease (CJD), which results from transmission of CJD prions in the course of medical procedures or treatments, and variant CJD (transmission via consumption of products from prion-diseased cows or via blood transfusion from an affected individual). [from ORDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCreutzfeldt-Jakob disease
- CROGVAcquired Creutzfeldt-Jakob disease
- CROGVInherited Creutzfeldt-Jakob disease

Disorder by Site
- Disorder of nervous system
  - Disorder of the central nervous system
    - Brain disorder
      - Dementia
        Creutzfeldt-Jakob disease
        Acquired Creutzfeldt-Jakob disease
        Iatrogenic Creutzfeldt-Jakob disease
        Variant Creutzfeldt-Jakob disease

Professional guidelines

PubMed

Neuropathological and biochemical criteria to identify acquired Creutzfeldt-Jakob disease among presumed sporadic cases.

Kobayashi A, Parchi P, Yamada M, Mohri S, Kitamoto T
Neuropathology 2016 Jun;36(3):305-10. Epub 2015 Dec 15 doi: 10.1111/neup.12270. PMID: 26669818

Phenothiazines: potential management of Creutzfeldt-Jacob disease and its variants.

Amaral L, Kristiansen JE
Int J Antimicrob Agents 2001 Nov;18(5):411-7. doi: 10.1016/s0924-8579(01)00432-0. PMID: 11711254

See all (2)

Recent clinical studies

Etiology

Creutzfeldt-Jakob disease and blood transfusion safety.

Seed CR, Hewitt PE, Dodd RY, Houston F, Cervenakova L
Vox Sang 2018 Apr;113(3):220-231. Epub 2018 Jan 22 doi: 10.1111/vox.12631. PMID: 29359329

Understanding the natural variability of prion diseases.

Geissen M, Krasemann S, Matschke J, Glatzel M
Vaccine 2007 Jul 26;25(30):5631-6. Epub 2007 Mar 7 doi: 10.1016/j.vaccine.2007.02.041. PMID: 17391814

Distribution of the M129V polymorphism of the prion protein gene in a Turkish population suggests a high risk for Creutzfeldt-Jakob disease.

Erginel-Unaltuna N, Peoc'h K, Komurcu E, Acuner TT, Issever H, Laplanche JL
Eur J Hum Genet 2001 Dec;9(12):965-8. doi: 10.1038/sj.ejhg.5200754. PMID: 11840201

See all (3)

Diagnosis

Creutzfeldt-Jakob disease and blood transfusion safety.

Seed CR, Hewitt PE, Dodd RY, Houston F, Cervenakova L
Vox Sang 2018 Apr;113(3):220-231. Epub 2018 Jan 22 doi: 10.1111/vox.12631. PMID: 29359329

Development of a quick bioassay for the evaluation of transmission properties of acquired prion diseases.

Munesue Y, Shimazaki T, Qi Z, Isoda N, Sawa H, Aoshima K, Kimura T, Mohri S, Kitamoto T, Kobayashi A
Neurosci Lett 2018 Mar 6;668:43-47. Epub 2018 Jan 9 doi: 10.1016/j.neulet.2018.01.014. PMID: 29329906

Neuropathological and biochemical criteria to identify acquired Creutzfeldt-Jakob disease among presumed sporadic cases.

Kobayashi A, Parchi P, Yamada M, Mohri S, Kitamoto T
Neuropathology 2016 Jun;36(3):305-10. Epub 2015 Dec 15 doi: 10.1111/neup.12270. PMID: 26669818

Understanding the natural variability of prion diseases.

Geissen M, Krasemann S, Matschke J, Glatzel M
Vaccine 2007 Jul 26;25(30):5631-6. Epub 2007 Mar 7 doi: 10.1016/j.vaccine.2007.02.041. PMID: 17391814

See all (4)