U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thyroid Gland Mucinous Follicular Adenoma

MedGen UID:
313778
•Concept ID:
C1710415
•
Neoplastic Process

Definition

A thyroid gland adenoma composed of follicles and characterized by the presence of abundant extracellular mucin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Mucinous Follicular Adenoma

Professional guidelines

PubMed

In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter.
Dwyer RM, Bergert ER, O'connor MK, Gendler SJ, Morris JC
Clin Cancer Res 2005 Feb 15;11(4):1483-9. doi: 10.1158/1078-0432.CCR-04-1636. PMID: 15746050

Recent clinical studies

Etiology

Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Epidemiology of Second Primary Tumors in Women With Ovarian Cancer.
Kanninen TT, Nasioudis D, Sisti G, Holcomb K, Di Tommaso M, Khalil S, Gojayev A, Witkin SS
Int J Gynecol Cancer 2017 May;27(4):659-667. doi: 10.1097/IGC.0000000000000950. PMID: 28441249
MUC1 mucin gene, transcripts, and protein in adenomas and papillary carcinomas of the thyroid.
Bièche I, Ruffet E, Zweibaum A, Vildé F, Lidereau R, Franc B
Thyroid 1997 Oct;7(5):725-31. doi: 10.1089/thy.1997.7.725. PMID: 9349575
New and unusual aspects of ovarian germ cell tumors.
Young RH
Am J Surg Pathol 1993 Dec;17(12):1210-24. doi: 10.1097/00000478-199312000-00002. PMID: 7694512
Solid cell nests of the thyroid.
Harach HR
J Pathol 1988 Jul;155(3):191-200. doi: 10.1002/path.1711550303. PMID: 3045277

Diagnosis

Top 10 Clear Cell Head and Neck Lesions to Contemplate.
Cipriani NA, Kakkar A
Head Neck Pathol 2023 Mar;17(1):33-52. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01518-6. PMID: 36928734Free PMC Article
SOX17: A Highly Sensitive and Specific Immunomarker for Ovarian and Endometrial Carcinomas.
Zhang X, Yao J, Niu N, Li X, Liu Y, Huo L, Euscher ED, Wang H, Bell D, Sood AK, Wang G, Lawson BC, Ramalingam P, Malpica A, Sahin AA, Ding Q, Liu J
Mod Pathol 2023 Feb;36(2):100001. Epub 2023 Jan 9 doi: 10.1016/j.modpat.2022.100001. PMID: 36853778
Identifying SOX17 as a Sensitive and Specific Marker for Ovarian and Endometrial Carcinomas.
Shaker N, Chen W, Sinclair W, Parwani AV, Li Z
Mod Pathol 2023 Jan;36(1):100038. doi: 10.1016/j.modpat.2022.100038. PMID: 36788073
Primary lesions that may imitate metastatic tumors histologically: A selective review.
Wick MR
Semin Diagn Pathol 2018 Mar;35(2):123-142. Epub 2017 Nov 17 doi: 10.1053/j.semdp.2017.11.010. PMID: 29174934
Fine-needle aspiration of mucin-producing thyroid tumors.
Yang GC, Scognamiglio T, Kuhel WI
Acta Cytol 2011;55(6):549-55. Epub 2011 Dec 9 doi: 10.1159/000333228. PMID: 22156465

Therapy

Carney complex: a clinicopathologic and molecular biological study of a sporadic case, including extracutaneous and cutaneous lesions and a novel mutation of the PRKAR1A gene.
Kacerovska D, Sima R, Michal M, Hes O, Roucka P, Zarybnicka M, Hora M, Chudacek Z, Kazakov DV
J Am Acad Dermatol 2009 Jul;61(1):80-7. doi: 10.1016/j.jaad.2008.11.015. PMID: 19539840
In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter.
Dwyer RM, Bergert ER, O'connor MK, Gendler SJ, Morris JC
Clin Cancer Res 2005 Feb 15;11(4):1483-9. doi: 10.1158/1078-0432.CCR-04-1636. PMID: 15746050
Unusual case of metastatic thyroid nodule: nonpalpable breast mass as origin.
Tutal E, Tütüncü NB, Akçaer N, Bilezikçi B, Güvener N, Arican A
Endocr Pract 2001 Sep-Oct;7(5):379-82. doi: 10.4158/EP.7.5.379. PMID: 11585375
Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity.
Nemunaitis J, Cunningham C, Buchanan A, Blackburn A, Edelman G, Maples P, Netto G, Tong A, Randlev B, Olson S, Kirn D
Gene Ther 2001 May;8(10):746-59. doi: 10.1038/sj.gt.3301424. PMID: 11420638
Current therapy of thyroid nodules.
Wright HK, Burrow GN, Spaulding S, Sheahan DG
Surg Clin North Am 1974 Apr;54(2):277-88. doi: 10.1016/s0039-6109(16)40279-3. PMID: 4361604

Prognosis

Mucinous breast carcinoma metastatic to thyroid gland: Report of a case diagnosed by fine-needle aspiration cytology.
Wang M, Liu X, Wei B, Liu N, Li Q, Su X
Diagn Cytopathol 2020 May;48(5):475-478. Epub 2020 Feb 17 doi: 10.1002/dc.24396. PMID: 32065477
Epidemiology of Second Primary Tumors in Women With Ovarian Cancer.
Kanninen TT, Nasioudis D, Sisti G, Holcomb K, Di Tommaso M, Khalil S, Gojayev A, Witkin SS
Int J Gynecol Cancer 2017 May;27(4):659-667. doi: 10.1097/IGC.0000000000000950. PMID: 28441249
Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity.
Shah AA, La Fortune K, Miller C, Mills SE, Baloch Z, LiVolsi V, Dacic S, Mahaffey AL, Nikiforova M, Nikiforov YE, Seethala RR
Mod Pathol 2017 Mar;30(3):329-339. Epub 2016 Dec 2 doi: 10.1038/modpathol.2016.180. PMID: 27910944Free PMC Article
Expression of the membrane mucins MUC4 and MUC15, potential markers of malignancy and prognosis, in papillary thyroid carcinoma.
Nam KH, Noh TW, Chung SH, Lee SH, Lee MK, Hong SW, Chung WY, Lee EJ, Park CS
Thyroid 2011 Jul;21(7):745-50. Epub 2011 May 26 doi: 10.1089/thy.2010.0339. PMID: 21615302
MUC1 mucin gene, transcripts, and protein in adenomas and papillary carcinomas of the thyroid.
Bièche I, Ruffet E, Zweibaum A, Vildé F, Lidereau R, Franc B
Thyroid 1997 Oct;7(5):725-31. doi: 10.1089/thy.1997.7.725. PMID: 9349575

Clinical prediction guides

Medullary carcinoma of the ampulla has distinct clinicopathologic characteristics including common association with microsatellite instability and PD-L1 expression.
Xue Y, Balci S, Pehlivanoglu B, Muraki T, Memis B, Saka B, Kim G, Bandyopadhyay S, Knight J, El-Rayes B, Kooby D, Maithel SK, Sarmiento J, Basturk O, Reid MD, Adsay V
Hum Pathol 2023 Jan;131:38-46. Epub 2022 Dec 9 doi: 10.1016/j.humpath.2022.12.004. PMID: 36502926
Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Primary lesions that may imitate metastatic tumors histologically: A selective review.
Wick MR
Semin Diagn Pathol 2018 Mar;35(2):123-142. Epub 2017 Nov 17 doi: 10.1053/j.semdp.2017.11.010. PMID: 29174934
Epidemiology of Second Primary Tumors in Women With Ovarian Cancer.
Kanninen TT, Nasioudis D, Sisti G, Holcomb K, Di Tommaso M, Khalil S, Gojayev A, Witkin SS
Int J Gynecol Cancer 2017 May;27(4):659-667. doi: 10.1097/IGC.0000000000000950. PMID: 28441249
MUC1 mucin gene, transcripts, and protein in adenomas and papillary carcinomas of the thyroid.
Bièche I, Ruffet E, Zweibaum A, Vildé F, Lidereau R, Franc B
Thyroid 1997 Oct;7(5):725-31. doi: 10.1089/thy.1997.7.725. PMID: 9349575

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...