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Thyroid Gland Hyperfunctioning Adenoma

MedGen UID:
354255
•Concept ID:
C1710419
•
Neoplastic Process
Synonyms: Thyroid Gland Hot Adenoma; Thyroid Gland Toxic (Hyperfunctioning) Adenoma; Thyroid Gland Toxic Adenoma

Definition

A thyroid gland adenoma producing thyroxin. It is associated with hyperthyroidism. Radioactive iodine scan reveals a hot nodule. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Hyperfunctioning Adenoma

Professional guidelines

PubMed

Primary hyperparathyroidism: from guidelines to outpatient clinic.
Palermo A, Tabacco G, Makras P, Zavatta G, Trimboli P, Castellano E, Yavropoulou MP, Naciu AM, Anastasilakis AD
Rev Endocr Metab Disord 2024 Oct;25(5):875-896. Epub 2024 Aug 20 doi: 10.1007/s11154-024-09899-5. PMID: 39162944
Dynamic 18F-fluorocholine PET/CT for parathyroid imaging in patients with primary hyperparathyroidism.
Broos WAM, Wondergem M, van der Zant FM, Schaper NC, Knol RJJ
Nucl Med Commun 2020 Aug;41(8):776-782. doi: 10.1097/MNM.0000000000001217. PMID: 32453204
Use of radiopharmaceuticals for diagnosis, treatment, and follow-up of differentiated thyroid carcinoma.
Verburg FA, de Keizer B, van Isselt JW
Anticancer Agents Med Chem 2007 Jul;7(4):399-409. doi: 10.2174/187152007781058578. PMID: 17630916

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Dynamic 18F-fluorocholine PET/CT for parathyroid imaging in patients with primary hyperparathyroidism.
Broos WAM, Wondergem M, van der Zant FM, Schaper NC, Knol RJJ
Nucl Med Commun 2020 Aug;41(8):776-782. doi: 10.1097/MNM.0000000000001217. PMID: 32453204
Otolaryngic manifestations of Cushing disease.
Kuan EC, Peng KA, Suh JD, Bergsneider M, Wang MB
Ear Nose Throat J 2017 Aug;96(8):E28-E30. doi: 10.1177/014556131709600808. PMID: 28846797
Endocrine incidentalomas.
Shirodkar M, Jabbour SA
Int J Clin Pract 2008 Sep;62(9):1423-31. Epub 2008 Jul 24 doi: 10.1111/j.1742-1241.2008.01831.x. PMID: 18657198
Adrenal surgery for hypercortisolism--surgical aspects.
van Heerden JA, Young WF Jr, Grant CS, Carpenter PC
Surgery 1995 Apr;117(4):466-72. doi: 10.1016/s0039-6060(05)80069-8. PMID: 7716730

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
The EANM practice guidelines for parathyroid imaging.
Petranović Ovčariček P, Giovanella L, Carrió Gasset I, Hindié E, Huellner MW, Luster M, Piccardo A, Weber T, Talbot JN, Verburg FA
Eur J Nucl Med Mol Imaging 2021 Aug;48(9):2801-2822. Epub 2021 Apr 10 doi: 10.1007/s00259-021-05334-y. PMID: 33839893Free PMC Article
Rare syndromes.
Jabbour SA, Davidovici BB, Wolf R
Clin Dermatol 2006 Jul-Aug;24(4):299-316. doi: 10.1016/j.clindermatol.2006.04.005. PMID: 16828412
Central hyperthyroidism.
McDermott MT, Ridgway EC
Endocrinol Metab Clin North Am 1998 Mar;27(1):187-203. doi: 10.1016/s0889-8529(05)70306-6. PMID: 9534036
Goiter in adolescents.
Foley TP Jr
Endocrinol Metab Clin North Am 1993 Sep;22(3):593-606. PMID: 8243449

Therapy

GATE based Monte Carlo simulation of planar scintigraphy to estimate the nodular dose in radioiodine therapy for autonomous thyroid adenoma.
Hammes J, Pietrzyk U, Schmidt M, Schicha H, Eschner W
Z Med Phys 2011 Dec;21(4):290-300. Epub 2011 Oct 7 doi: 10.1016/j.zemedi.2011.09.002. PMID: 21983024
Burkitt-like lymphoma infiltrating a hyperfunctioning thyroid adenoma and presenting as a hot nodule.
Camera A, Magri F, Fonte R, Villani L, Della Porta MG, Fregoni V, Manna LL, Chiovato L
Thyroid 2010 Sep;20(9):1033-6. doi: 10.1089/thy.2010.0048. PMID: 20825299
Intraoperative parathormone measurements and postoperative hypocalcemia.
Stepansky A, Gold-Deutch R, Poluksht N, Hagag P, Benbassat C, Mor A, Aharoni D, Wassermann I, Halpern Z, Halevy A
Isr Med Assoc J 2010 Apr;12(4):207-10. PMID: 20803878
Use of radiopharmaceuticals for diagnosis, treatment, and follow-up of differentiated thyroid carcinoma.
Verburg FA, de Keizer B, van Isselt JW
Anticancer Agents Med Chem 2007 Jul;7(4):399-409. doi: 10.2174/187152007781058578. PMID: 17630916
Hyperfunctioning intrathyroid parathyroid gland: a potential cause of failure in parathyroidectomy.
Bahar G, Feinmesser R, Joshua BZ, Shpitzer T, Morgenstein S, Popovtzer A, Shvero J
Surgery 2006 Jun;139(6):821-6. doi: 10.1016/j.surg.2005.11.009. PMID: 16782440

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
A Rare Case of Primary Hyperparathyroidism Caused by a Giant Solitary Parathyroid Adenoma.
Mantzoros I, Kyriakidou D, Galanos-Demiris K, Chatzakis C, Parpoudi S, Sapidis N, Loutzidou L, Ioannidis O, Angelopoulos S, Tsalis KG
Am J Case Rep 2018 Nov 8;19:1334-1337. doi: 10.12659/AJCR.911452. PMID: 30405093Free PMC Article
Intraoperative parathormone measurements and postoperative hypocalcemia.
Stepansky A, Gold-Deutch R, Poluksht N, Hagag P, Benbassat C, Mor A, Aharoni D, Wassermann I, Halpern Z, Halevy A
Isr Med Assoc J 2010 Apr;12(4):207-10. PMID: 20803878
Use of radiopharmaceuticals for diagnosis, treatment, and follow-up of differentiated thyroid carcinoma.
Verburg FA, de Keizer B, van Isselt JW
Anticancer Agents Med Chem 2007 Jul;7(4):399-409. doi: 10.2174/187152007781058578. PMID: 17630916
Goiter in adolescents.
Foley TP Jr
Endocrinol Metab Clin North Am 1993 Sep;22(3):593-606. PMID: 8243449

Clinical prediction guides

Differential regulation of monocarboxylate transporter 8 expression in thyroid cancer and hyperthyroidism.
Badziong J, Ting S, Synoracki S, Tiedje V, Brix K, Brabant G, Moeller LC, Schmid KW, Fuhrer D, Zwanziger D
Eur J Endocrinol 2017 Sep;177(3):243-250. Epub 2017 Jun 2 doi: 10.1530/EJE-17-0279. PMID: 28576880
Evaluation of proliferation potential in thyroid normo-/hypofunctioning and hyperfunctioning nodules.
Cornianu M, Stan V, Lazăr E, Dema A, Golu I, Tăban S, Vlad M, Faur A, Vărcuş F, Babău F
Rom J Morphol Embryol 2011;52(2):545-53. PMID: 21655641
Intraoperative parathormone measurements and postoperative hypocalcemia.
Stepansky A, Gold-Deutch R, Poluksht N, Hagag P, Benbassat C, Mor A, Aharoni D, Wassermann I, Halpern Z, Halevy A
Isr Med Assoc J 2010 Apr;12(4):207-10. PMID: 20803878
Endocrine diseases in dogs and cats: similarities and differences with endocrine diseases in humans.
Rijnberk A, Kooistra HS, Mol JA
Growth Horm IGF Res 2003 Aug;13 Suppl A:S158-64. doi: 10.1016/s1096-6374(03)00076-5. PMID: 12914747
Characterization of autonomous thyroid adenoma: metabolism, gene expression, and pathology.
Deleu S, Allory Y, Radulescu A, Pirson I, Carrasco N, Corvilain B, Salmon I, Franc B, Dumont JE, Van Sande J, Maenhaut C
Thyroid 2000 Feb;10(2):131-40. doi: 10.1089/thy.2000.10.131. PMID: 10718549

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