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Series GSE53987 Query DataSets for GSE53987
Status Public on Jan 11, 2014
Title Microarray profiling of PFC, HPC and STR from subjects with schizophrenia, bipolar, MDD or control
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Schizophrenia is a complex psychiatric disorder encompassing a range of symptoms and etiology dependent upon the interaction of genetic and environmental factors. Several risk genes, such as DISC1, have been associated with schizophrenia as well as bipolar disorder (BPD) and major depressive disorder (MDD), consistent with the hypothesis that a shared genetic architecture could contribute to divergent clinical syndromes. The present study compared gene expression profiles across three brain regions in post-mortem tissue from matched subjects with schizophrenia, BPD or MDD and unaffected controls. Post-mortem brain tissue was collected from control subjects and well-matched subjects with schizophrenia, BPD, and MDD (n=19 from each group). RNA was isolated from hippocampus, Brodmann Area 46, and associative striatum and hybridized to U133_Plus2 Affymetrix chips. Data were normalized by RMA, subjected to pairwise comparison followed by Benjamini and Hochberg False Discovery Rate correction (FDR). Samples derived from patients with schizophrenia exhibited many more changes in gene expression across all brain regions than observed in BPD or MDD. Several genes showed changes in both schizophrenia and BPD, though the magnitude of change was usually larger in schizophrenia. Several genes that have variants associated with schizophrenia were found to have altered expression in multiple regions of brains from subjects with schizophrenia. Continued evaluation of circuit-level alterations in gene expression and gene-network relationships may further our understanding of how genetic variants may be influencing biological processes to contribute to psychiatric disease.
Overall design Pre-frontal cortex, striatum and hippocampus were obtained from subjects with schizophrenia, bipolar disorder, major depressive disorder and matched controls.
Contributor(s) Lanz TA
Citation(s) 31123247
Submission date Jan 10, 2014
Last update date Jun 17, 2019
Contact name Thomas A Lanz
Phone 860-441-3551
Organization name Pfizer
Department Global Pathology and Investigative Toxicology
Street address Eastern Point Rd MS# 8274-1224
City Groton
State/province CT
ZIP/Postal code 06340
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (205)
GSM1304852 bipolar_hip_10
GSM1304853 bipolar_hip_11
GSM1304854 bipolar_hip_12
BioProject PRJNA234287

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Supplementary file Size Download File type/resource
GSE53987_RAW.tar 978.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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