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Series GSE7956 Query DataSets for GSE7956
Status Public on Oct 02, 2007
Title Gene Signature for Aggression of Melanoma Metastases - Melanoma Metastasis (LeiFidler)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis.
Keywords: disease state analysis
Overall design parental cell line vs xenograft model
Contributor(s) Xu L, Shen SS, Hoshida Y, Subramanian A, Ross K, Brunet J, Wagner SN, Ramaswamy S, Mesirov JP, Hynes RO
Citation(s) 18505921
Submission date May 30, 2007
Last update date Aug 10, 2018
Contact name steve shen
Organization name MIT
Street address 77 mass ave
City cambridge
State/province MA
ZIP/Postal code 02139
Country USA
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (39)
GSM195320 Melanoma metastatic cell line A375, P1, biol rep1 (LeiFidler)
GSM195321 Melanoma metastatic cell line A375, P2, biol rep2 (LeiFidler)
GSM195322 Melanoma metastatic cell line A375, P3, biol rep3 (LeiFidler)
BioProject PRJNA100701

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7956_RAW.tar 137.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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