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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 14, 2015 |
| Title |
Gene expression data from Lhx5 mutant mouse embryos |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Lhx5 mutant mouse embryos show loss of a neuronal nucleus of the brain called the mamillary body and essential for the formation of memories. We wanted to identify the genes that are responsible for the normal development of the mammillary body.
Therefore, we used microarray experiments to identify the genes that show a changed expression in the Lhx5 mutant mammillary neuroepithelium in comparison to the wild type.
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| Overall design |
The mammillary neuroepithelium of Lhx5 mutant und wild type embryos (Mus musculus (C57BL/6)) was dissected at a stage, where the size of the mammillary body was not yet detectable changed (E10.5) to exclude effects of the size reduction of the mammillary body in Lhx5 mutant embryos. RNA extraction and hybridization on Affymetrix microarrays was performed to detect changes in the transcriptome that are responsible for the mutant phenotype.
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| Contributor(s) |
Heide M, Alvarez-Bolado G |
| Citation(s) |
26321924 |
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| Submission date |
Sep 22, 2014 |
| Last update date |
Apr 18, 2017 |
| Contact name |
Gonzalo Alvarez-Bolado |
| Organization name |
Institute for Anatomy and Cell Biology
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| Street address |
Im Neuenheimer Feld 307
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| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
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| Platforms (1) |
| GPL11533 |
[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (25)
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| GSM1509393 |
mammillary body, KO, biological rep4 |
| GSM1509394 |
mammillary body, KO, biological rep5 |
| GSM1509395 |
mammillary body, KO, biological rep6 |
| GSM1509396 |
mammillary body, KO, biological rep7 |
| GSM1509397 |
mammillary body, KO, biological rep8 |
| GSM1509398 |
mammillary body, KO, biological rep9 |
| GSM1509399 |
mammillary body, KO, biological rep10 |
| GSM1509400 |
mammillary body, KO, biological rep11 |
| GSM1509401 |
mammillary body, KO, biological rep12 |
| GSM1509402 |
mammillary body, KO, biological rep13 |
| GSM1509403 |
mammillary body, WT, biological rep1 |
| GSM1509404 |
mammillary body, WT, biological rep2 |
| GSM1509405 |
mammillary body, WT, biological rep3 |
| GSM1509406 |
mammillary body, WT, biological rep4 |
| GSM1509407 |
mammillary body, WT, biological rep5 |
| GSM1509408 |
mammillary body, WT, biological rep6 |
| GSM1509409 |
mammillary body, WT, biological rep7 |
| GSM1509410 |
mammillary body, WT, biological rep8 |
| GSM1509411 |
mammillary body, WT, biological rep9 |
| GSM1509412 |
mammillary body, WT, biological rep10 |
| GSM1509413 |
mammillary body, WT, biological rep11 |
| GSM1509414 |
mammillary body, WT, biological rep12 |
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| This SubSeries is part of SuperSeries: |
| GSE61614 |
Identification of Lhx5 binding sites and Gene expression data from Lhx5 mutant mouse embryos |
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| Relations |
| BioProject |
PRJNA261692 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE61612_RAW.tar |
109.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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