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| Status |
Public on Aug 01, 2012 |
| Title |
Blood gene expression signatures distinguish autism spectrum disorders from controls |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Autism Spectrum Disorder (ASD) is a common pediatric cognitive disorder with high heritability. Yet no single genetic variant has accounted for more than a small fraction of cases. We sought to determine whether we could classify patients as having ASD vs. controls solely based on a multi-gene expression profiling of their peripheral blood cells.
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| Overall design |
To test whether peripheral blood gene expression profiles could be used as a molecular diagnostic tool for distinguishing ASD from controls, we performed peripheral blood gene expression profiling on 170 patients with ASD and 115 controls collected from Boston area hospitals. We developed a 55-gene prediction model with a sample cohort of 66 male patients with ASD and 33 age-matched male controls using cross-validation strategy. Subsequently, 104 ASD and 82 controls were recruited and used as first and second validation sets, respectively.
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| Contributor(s) |
Kong S, Collins C, Holm IA, Kunkel LM, Kohane IS |
| Citation(s) |
23227143 |
| Submission date |
Sep 15, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Sek Won Kong |
| E-mail(s) |
swkong@enders.tch.harvard.edu
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| Phone |
617-919-2689
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| Organization name |
Boston Children's Hospital
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| Department |
Informatics Program
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| Lab |
EN137
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| Street address |
300 Longwood Avenue
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (2) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (285)
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| Relations |
| BioProject |
PRJNA119451 |
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